Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413305964> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2413305964 endingPage "803" @default.
- W2413305964 startingPage "798" @default.
- W2413305964 abstract "To investigate the prevalence of Epstein-Barr virus (EBV)-associated gastric carcinomas in Guangzhou, their clinicopathologic features and related protein expressions including DNMT1, p16, and cyclin D1.A total of 676 cases of EBV-associated gastric carcinoma were included in the study. The presence of EBV-encoded small RNA1 (EBER1), a marker for EBV infection, was analyzed by in-situ hybridization using formalin-fixed and paraffin-embedded tumor samples. Expression of EBV-encoded proteins, DNMT1, p16 and cyclin D1 were detected by immunohistochemistry.Forty-five of 676 gastric carcinomas showed EBER intranuclear positivity in all tumor cells. EBV involvement was significantly more frequent among the male than the female patients, especially in tumors of less differentiated types (diffuse type) and involving the upper stomach (P < 0.05). EBNA1 and LMP2A expression were detected in 42 (93.3%) and 24 (53.3%) cases, respectively. None expressed EBNA2, LMP1, and ZEBRA. Among 45 cases of EBV associated gastric carcinomas, DNMT1, p16 and cyclin D1 expression were seen in 35 (77.8%), 10 (22.2%), and 29 (64.4%) cases, respectively. In contrast, among 40 EBV negative gastric carcinomas, expression of the three proteins were 20 (50.0%), 25 (62.5%) and 12 (30.0%), respectively. The difference of expression of the three proteins between the two groups was significant (P < 0.05). Expression of p16 correlated with the depth of the tumor invasion. Correlated protein expression was seen between LMP2A and DNMT1, between DNMT1 and p16, and between p16 and cyclin D1 (P < 0.05).EBV associated gastric carcinoma accounts for 6.7% of gastric carcinomas in Guangzhou with the Latency I pattern in some cases and between Latency I and II in others. The correlated expression of LMP2A, DNMT1, p16 and cyclin D1 may contribute to the pathogenesis of EBV associated gastric carcinomas." @default.
- W2413305964 created "2016-06-24" @default.
- W2413305964 creator A5027927544 @default.
- W2413305964 creator A5062092477 @default.
- W2413305964 creator A5069921704 @default.
- W2413305964 creator A5074850486 @default.
- W2413305964 creator A5086783805 @default.
- W2413305964 date "2010-12-01" @default.
- W2413305964 modified "2023-09-23" @default.
- W2413305964 title "[Clinicopathologic features and protein expression study of Epstein-Barr virus-associated gastric carcinoma in Guangzhou]." @default.
- W2413305964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21215093" @default.
- W2413305964 hasPublicationYear "2010" @default.
- W2413305964 type Work @default.
- W2413305964 sameAs 2413305964 @default.
- W2413305964 citedByCount "4" @default.
- W2413305964 countsByYear W24133059642012 @default.
- W2413305964 countsByYear W24133059642014 @default.
- W2413305964 countsByYear W24133059642015 @default.
- W2413305964 countsByYear W24133059642017 @default.
- W2413305964 crossrefType "journal-article" @default.
- W2413305964 hasAuthorship W2413305964A5027927544 @default.
- W2413305964 hasAuthorship W2413305964A5062092477 @default.
- W2413305964 hasAuthorship W2413305964A5069921704 @default.
- W2413305964 hasAuthorship W2413305964A5074850486 @default.
- W2413305964 hasAuthorship W2413305964A5086783805 @default.
- W2413305964 hasConcept C104317684 @default.
- W2413305964 hasConcept C142724271 @default.
- W2413305964 hasConcept C150194340 @default.
- W2413305964 hasConcept C159047783 @default.
- W2413305964 hasConcept C175211621 @default.
- W2413305964 hasConcept C190727270 @default.
- W2413305964 hasConcept C199835354 @default.
- W2413305964 hasConcept C204232928 @default.
- W2413305964 hasConcept C2522874641 @default.
- W2413305964 hasConcept C2779422922 @default.
- W2413305964 hasConcept C2780494569 @default.
- W2413305964 hasConcept C2781375147 @default.
- W2413305964 hasConcept C29537977 @default.
- W2413305964 hasConcept C502942594 @default.
- W2413305964 hasConcept C55493867 @default.
- W2413305964 hasConcept C71924100 @default.
- W2413305964 hasConcept C81439078 @default.
- W2413305964 hasConcept C86803240 @default.
- W2413305964 hasConceptScore W2413305964C104317684 @default.
- W2413305964 hasConceptScore W2413305964C142724271 @default.
- W2413305964 hasConceptScore W2413305964C150194340 @default.
- W2413305964 hasConceptScore W2413305964C159047783 @default.
- W2413305964 hasConceptScore W2413305964C175211621 @default.
- W2413305964 hasConceptScore W2413305964C190727270 @default.
- W2413305964 hasConceptScore W2413305964C199835354 @default.
- W2413305964 hasConceptScore W2413305964C204232928 @default.
- W2413305964 hasConceptScore W2413305964C2522874641 @default.
- W2413305964 hasConceptScore W2413305964C2779422922 @default.
- W2413305964 hasConceptScore W2413305964C2780494569 @default.
- W2413305964 hasConceptScore W2413305964C2781375147 @default.
- W2413305964 hasConceptScore W2413305964C29537977 @default.
- W2413305964 hasConceptScore W2413305964C502942594 @default.
- W2413305964 hasConceptScore W2413305964C55493867 @default.
- W2413305964 hasConceptScore W2413305964C71924100 @default.
- W2413305964 hasConceptScore W2413305964C81439078 @default.
- W2413305964 hasConceptScore W2413305964C86803240 @default.
- W2413305964 hasIssue "12" @default.
- W2413305964 hasLocation W24133059641 @default.
- W2413305964 hasOpenAccess W2413305964 @default.
- W2413305964 hasPrimaryLocation W24133059641 @default.
- W2413305964 hasRelatedWork W107580712 @default.
- W2413305964 hasRelatedWork W2028138784 @default.
- W2413305964 hasRelatedWork W2041581149 @default.
- W2413305964 hasRelatedWork W2062716688 @default.
- W2413305964 hasRelatedWork W2066192011 @default.
- W2413305964 hasRelatedWork W2347872864 @default.
- W2413305964 hasRelatedWork W2354971223 @default.
- W2413305964 hasRelatedWork W2359557297 @default.
- W2413305964 hasRelatedWork W2368081886 @default.
- W2413305964 hasRelatedWork W2372464396 @default.
- W2413305964 hasRelatedWork W2372739328 @default.
- W2413305964 hasRelatedWork W2380805599 @default.
- W2413305964 hasRelatedWork W2381236337 @default.
- W2413305964 hasRelatedWork W2414022624 @default.
- W2413305964 hasRelatedWork W2472412159 @default.
- W2413305964 hasRelatedWork W2601508031 @default.
- W2413305964 hasRelatedWork W2891473648 @default.
- W2413305964 hasRelatedWork W2969606732 @default.
- W2413305964 hasRelatedWork W3016533670 @default.
- W2413305964 hasRelatedWork W303005829 @default.
- W2413305964 hasVolume "39" @default.
- W2413305964 isParatext "false" @default.
- W2413305964 isRetracted "false" @default.
- W2413305964 magId "2413305964" @default.
- W2413305964 workType "article" @default.