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- W2413307675 startingPage "8" @default.
- W2413307675 abstract "Activation of the neuro-hormonal system is a pathophysiological consequence of heart failure. Neuro-hormonal activation promotes metabolic changes, such as insulin resistance, and determines an increased use of non-carbohydrate substrates for energy production. Fasting blood ketone bodies as well as fat oxidation are increased in patients with heart failure, yielding a state of metabolic inefficiency. The net result is additional depletion of myocardial adenosine triphosphate, phosphocreatine and creatine kinase levels with further decreased efficiency of mechanical work. In this context, manipulation of cardiac energy metabolism by modification of substrate use by the failing heart has produced positive clinical results. The results of current research support the concept that shifting the energy substrate preference away from fatty acid metabolism and towards glucose metabolism could be an effective adjunctive treatment in patients with heart failure. The additional use of drugs able to partially inhibit fatty acids oxidation in patients with heart failure may therefore yield a significant protective effect for clinical symptoms and cardiac function improvement, and simultaneously ameliorate left ventricular remodelling. Certainly, to clarify the exact therapeutic role of metabolic therapy in heart failure, a large multicentre, randomised controlled trial should be performed." @default.
- W2413307675 created "2016-06-24" @default.
- W2413307675 creator A5058522254 @default.
- W2413307675 date "2016-01-01" @default.
- W2413307675 modified "2023-10-05" @default.
- W2413307675 title "Deranged cardiac metabolism and the pathogenesis of heart failure" @default.
- W2413307675 cites W148373708 @default.
- W2413307675 cites W1571718974 @default.
- W2413307675 cites W1584301804 @default.
- W2413307675 cites W159425132 @default.
- W2413307675 cites W1814201580 @default.
- W2413307675 cites W1965928493 @default.
- W2413307675 cites W1971240641 @default.
- W2413307675 cites W1974150164 @default.
- W2413307675 cites W1974372282 @default.
- W2413307675 cites W1975615748 @default.
- W2413307675 cites W1978069233 @default.
- W2413307675 cites W1978717387 @default.
- W2413307675 cites W1978727819 @default.
- W2413307675 cites W1979190934 @default.
- W2413307675 cites W1979604318 @default.
- W2413307675 cites W1979759472 @default.
- W2413307675 cites W1987424918 @default.
- W2413307675 cites W1991385182 @default.
- W2413307675 cites W1991593759 @default.
- W2413307675 cites W1992786030 @default.
- W2413307675 cites W1997997206 @default.
- W2413307675 cites W2011315228 @default.
- W2413307675 cites W2012076066 @default.
- W2413307675 cites W2012099061 @default.
- W2413307675 cites W2012614524 @default.
- W2413307675 cites W2012898950 @default.
- W2413307675 cites W2015145254 @default.
- W2413307675 cites W2017615202 @default.
- W2413307675 cites W2017617134 @default.
- W2413307675 cites W2021879626 @default.
- W2413307675 cites W2023731159 @default.
- W2413307675 cites W2023757364 @default.
- W2413307675 cites W2024534607 @default.
- W2413307675 cites W2025542744 @default.
- W2413307675 cites W2031003564 @default.
- W2413307675 cites W2031545586 @default.
- W2413307675 cites W2037361270 @default.
- W2413307675 cites W2037687961 @default.
- W2413307675 cites W2042958331 @default.
- W2413307675 cites W2057658004 @default.
- W2413307675 cites W2059165993 @default.
- W2413307675 cites W2061156339 @default.
- W2413307675 cites W2063775163 @default.
- W2413307675 cites W2065205257 @default.
- W2413307675 cites W2066010467 @default.
- W2413307675 cites W2067090468 @default.
- W2413307675 cites W2071792752 @default.
- W2413307675 cites W2079709085 @default.
- W2413307675 cites W2081133653 @default.
- W2413307675 cites W2094648371 @default.
- W2413307675 cites W2095274796 @default.
- W2413307675 cites W2098089737 @default.
- W2413307675 cites W2101475697 @default.
- W2413307675 cites W2101881994 @default.
- W2413307675 cites W2102308209 @default.
- W2413307675 cites W2102676586 @default.
- W2413307675 cites W2108668031 @default.
- W2413307675 cites W2110533832 @default.
- W2413307675 cites W2117205119 @default.
- W2413307675 cites W2118539741 @default.
- W2413307675 cites W2119676906 @default.
- W2413307675 cites W2123521914 @default.
- W2413307675 cites W2123632616 @default.
- W2413307675 cites W2124941371 @default.
- W2413307675 cites W2125743550 @default.
- W2413307675 cites W2127500778 @default.
- W2413307675 cites W2128606426 @default.
- W2413307675 cites W2129967926 @default.
- W2413307675 cites W2130368504 @default.
- W2413307675 cites W2135398118 @default.
- W2413307675 cites W2136642260 @default.
- W2413307675 cites W2136834760 @default.
- W2413307675 cites W2137888087 @default.
- W2413307675 cites W2138760339 @default.
- W2413307675 cites W2143375551 @default.
- W2413307675 cites W2143725549 @default.
- W2413307675 cites W2149310427 @default.
- W2413307675 cites W2153760325 @default.
- W2413307675 cites W2153769155 @default.
- W2413307675 cites W2153819921 @default.
- W2413307675 cites W2154258710 @default.
- W2413307675 cites W2159337133 @default.
- W2413307675 cites W2164048313 @default.
- W2413307675 cites W2167018359 @default.
- W2413307675 cites W2168709801 @default.
- W2413307675 cites W2172941688 @default.
- W2413307675 cites W2207960351 @default.
- W2413307675 cites W2264108710 @default.
- W2413307675 cites W2328073587 @default.
- W2413307675 cites W2340837998 @default.
- W2413307675 cites W2414332321 @default.
- W2413307675 cites W2471485308 @default.