FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413309626> ?p ?o ?g. }

• W2413309626 endingPage "826" @default.
• W2413309626 startingPage "817" @default.
• W2413309626 abstract "Cholangiocarcinoma is a relatively rare cancer, but its incidence is increasing worldwide. Although several risk factors have been suggested, the etiology and pathogenesis of the majority of cholangiocarcinomas remain unclear. Recently, a high incidence of early-onset cholangiocarcinoma was reported among the workers of a printing company in Osaka, Japan. These workers underwent high exposure to organic solvents, mainly haloalkanes such as 1,2-dichloropropane (1,2-DCP) and/or dichloromethane. We performed whole-exome analysis on four cases of cholangiocarcinoma among the printing workers. An average of 44.8 somatic mutations was detected per Mb in the genome of the printing workers’ cholangiocarcinoma tissues, approximately 30-fold higher than that found in control common cholangiocarcinoma tissues. Furthermore, C:G-to-T:A transitions with substantial strand bias as well as unique trinucleotide mutational changes of GpCpY to GpTpY and NpCpY to NpTpY or NpApY were predominant in all of the printing workers’ cholangiocarcinoma genomes. These results were consistent with the epidemiological observation that they had been exposed to high concentrations of chemical compounds. Whole-genome analysis of Salmonella typhimurium strain TA100 exposed to 1,2-DCP revealed a partial recapitulation of the mutational signature in the printing workers’ cholangiocarcinoma. Although our results provide mutational signatures unique to occupational cholangiocarcinoma, the underlying mechanisms of the disease should be further investigated by using appropriate model systems and by comparison with genomic data from other cancers." @default.
• W2413309626 created "2016-06-24" @default.
• W2413309626 creator A5001408222 @default.
• W2413309626 creator A5004769553 @default.
• W2413309626 creator A5014204252 @default.
• W2413309626 creator A5017586108 @default.
• W2413309626 creator A5019552370 @default.
• W2413309626 creator A5028717780 @default.
• W2413309626 creator A5035470185 @default.
• W2413309626 creator A5038375140 @default.
• W2413309626 creator A5045940548 @default.
• W2413309626 creator A5047468314 @default.
• W2413309626 creator A5049137704 @default.
• W2413309626 creator A5054256781 @default.
• W2413309626 creator A5056573153 @default.
• W2413309626 creator A5056645736 @default.
• W2413309626 creator A5060248247 @default.
• W2413309626 creator A5071589326 @default.
• W2413309626 creator A5073951912 @default.
• W2413309626 creator A5076066875 @default.
• W2413309626 creator A5084852275 @default.
• W2413309626 date "2016-06-07" @default.
• W2413309626 modified "2023-10-04" @default.
• W2413309626 title "Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes" @default.
• W2413309626 cites W1259363667 @default.
• W2413309626 cites W1513182594 @default.
• W2413309626 cites W1520271781 @default.
• W2413309626 cites W1903979702 @default.
• W2413309626 cites W1963971189 @default.
• W2413309626 cites W1964918803 @default.
• W2413309626 cites W1972063953 @default.
• W2413309626 cites W1976453250 @default.
• W2413309626 cites W1980597479 @default.
• W2413309626 cites W1987580232 @default.
• W2413309626 cites W1995818228 @default.
• W2413309626 cites W2003089350 @default.
• W2413309626 cites W2003411025 @default.
• W2413309626 cites W2008782135 @default.
• W2413309626 cites W2014993686 @default.
• W2413309626 cites W2024663376 @default.
• W2413309626 cites W2025130792 @default.
• W2413309626 cites W2028464471 @default.
• W2413309626 cites W2032409312 @default.
• W2413309626 cites W2033522521 @default.
• W2413309626 cites W2037614104 @default.
• W2413309626 cites W2039993436 @default.
• W2413309626 cites W2046711617 @default.
• W2413309626 cites W2047578834 @default.
• W2413309626 cites W2048319329 @default.
• W2413309626 cites W2049538608 @default.
• W2413309626 cites W2050774050 @default.
• W2413309626 cites W2059828267 @default.
• W2413309626 cites W2062653770 @default.
• W2413309626 cites W2065542962 @default.
• W2413309626 cites W2080467722 @default.
• W2413309626 cites W2086415838 @default.
• W2413309626 cites W2097336697 @default.
• W2413309626 cites W2101898479 @default.
• W2413309626 cites W2103086380 @default.
• W2413309626 cites W2110941552 @default.
• W2413309626 cites W2117674153 @default.
• W2413309626 cites W2118133351 @default.
• W2413309626 cites W2144412903 @default.
• W2413309626 cites W2148300747 @default.
• W2413309626 cites W2150677022 @default.
• W2413309626 cites W2152061559 @default.
• W2413309626 cites W2152078686 @default.
• W2413309626 cites W2169882112 @default.
• W2413309626 cites W2311663614 @default.
• W2413309626 cites W4211025847 @default.
• W2413309626 cites W4211234270 @default.
• W2413309626 cites W4298071696 @default.
• W2413309626 cites W4301019720 @default.
• W2413309626 doi "https://doi.org/10.1093/carcin/bgw066" @default.
• W2413309626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4967217" @default.
• W2413309626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27267998" @default.
• W2413309626 hasPublicationYear "2016" @default.
• W2413309626 type Work @default.
• W2413309626 sameAs 2413309626 @default.
• W2413309626 citedByCount "61" @default.
• W2413309626 countsByYear W24133096262017 @default.
• W2413309626 countsByYear W24133096262018 @default.
• W2413309626 countsByYear W24133096262019 @default.
• W2413309626 countsByYear W24133096262020 @default.
• W2413309626 countsByYear W24133096262021 @default.
• W2413309626 countsByYear W24133096262022 @default.
• W2413309626 countsByYear W24133096262023 @default.
• W2413309626 crossrefType "journal-article" @default.
• W2413309626 hasAuthorship W2413309626A5001408222 @default.
• W2413309626 hasAuthorship W2413309626A5004769553 @default.
• W2413309626 hasAuthorship W2413309626A5014204252 @default.
• W2413309626 hasAuthorship W2413309626A5017586108 @default.
• W2413309626 hasAuthorship W2413309626A5019552370 @default.
• W2413309626 hasAuthorship W2413309626A5028717780 @default.
• W2413309626 hasAuthorship W2413309626A5035470185 @default.
• W2413309626 hasAuthorship W2413309626A5038375140 @default.
• W2413309626 hasAuthorship W2413309626A5045940548 @default.
• W2413309626 hasAuthorship W2413309626A5047468314 @default.

• next