Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413309628> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2413309628 endingPage "67" @default.
- W2413309628 startingPage "57" @default.
- W2413309628 abstract "We examined the involvement of cytochrome P-450 in the oxidation of diethyldithiocarbamate (DTC) to disulfiram (DS) by liver microsomes in the presence of NADPH. DS difference spectra of liver microsomes showed a peak and trough at about 385 and 418 nm, respectively, which disappeared after further addition of glutathione (GSH). DTC alone had little effect on the microsomal spectrum, however, the addition of NADPH gradually produced a spectral change having a trough at 416-417 nm, which waned upon further addition of GSH. Microsomal DS production was increased by phenobarbital pretreatment and decreased by carbon tetrachloride pretreatment, depending on the activity of the cytochrome P-450-monooxygenase system. With microsomes peroxidized by cumene hydroperoxide, the extent of NADPH-dependent DS production lowered in proportion to the decrease in cytochrome P-450. Inhibitors of cytochrome P-450 such as SKF-525A, metyrapone and n-octylamine dose-dependently inhibited the DS production. Sodium azide, an inhibitor of catalase, increased the DS production, whereas addition of exogenous catalase only slightly suppressed it. It is concluded that oxidation of DTC to DS by liver microsomes largely proceeds via the cytochrome P-450-containing monooxygenase system and partly by hydrogen peroxide generated during NADPH oxidation." @default.
- W2413309628 created "2016-06-24" @default.
- W2413309628 creator A5044478467 @default.
- W2413309628 creator A5079888720 @default.
- W2413309628 date "1989-10-01" @default.
- W2413309628 modified "2023-09-26" @default.
- W2413309628 title "Oxidation of diethyldithiocarbamate to disulfiram by liver microsomal cytochrome P-450-containing monooxygenase system." @default.
- W2413309628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2559440" @default.
- W2413309628 hasPublicationYear "1989" @default.
- W2413309628 type Work @default.
- W2413309628 sameAs 2413309628 @default.
- W2413309628 citedByCount "0" @default.
- W2413309628 crossrefType "journal-article" @default.
- W2413309628 hasAuthorship W2413309628A5044478467 @default.
- W2413309628 hasAuthorship W2413309628A5079888720 @default.
- W2413309628 hasConcept C13002179 @default.
- W2413309628 hasConcept C178790620 @default.
- W2413309628 hasConcept C181199279 @default.
- W2413309628 hasConcept C185592680 @default.
- W2413309628 hasConcept C2776524530 @default.
- W2413309628 hasConcept C2777359374 @default.
- W2413309628 hasConcept C2778523461 @default.
- W2413309628 hasConcept C2778793413 @default.
- W2413309628 hasConcept C2778979269 @default.
- W2413309628 hasConcept C2780768313 @default.
- W2413309628 hasConcept C2781417787 @default.
- W2413309628 hasConcept C526171541 @default.
- W2413309628 hasConcept C538909803 @default.
- W2413309628 hasConcept C55493867 @default.
- W2413309628 hasConcept C62231903 @default.
- W2413309628 hasConcept C86803240 @default.
- W2413309628 hasConcept C87644729 @default.
- W2413309628 hasConcept C98274493 @default.
- W2413309628 hasConceptScore W2413309628C13002179 @default.
- W2413309628 hasConceptScore W2413309628C178790620 @default.
- W2413309628 hasConceptScore W2413309628C181199279 @default.
- W2413309628 hasConceptScore W2413309628C185592680 @default.
- W2413309628 hasConceptScore W2413309628C2776524530 @default.
- W2413309628 hasConceptScore W2413309628C2777359374 @default.
- W2413309628 hasConceptScore W2413309628C2778523461 @default.
- W2413309628 hasConceptScore W2413309628C2778793413 @default.
- W2413309628 hasConceptScore W2413309628C2778979269 @default.
- W2413309628 hasConceptScore W2413309628C2780768313 @default.
- W2413309628 hasConceptScore W2413309628C2781417787 @default.
- W2413309628 hasConceptScore W2413309628C526171541 @default.
- W2413309628 hasConceptScore W2413309628C538909803 @default.
- W2413309628 hasConceptScore W2413309628C55493867 @default.
- W2413309628 hasConceptScore W2413309628C62231903 @default.
- W2413309628 hasConceptScore W2413309628C86803240 @default.
- W2413309628 hasConceptScore W2413309628C87644729 @default.
- W2413309628 hasConceptScore W2413309628C98274493 @default.
- W2413309628 hasIssue "1" @default.
- W2413309628 hasLocation W24133096281 @default.
- W2413309628 hasOpenAccess W2413309628 @default.
- W2413309628 hasPrimaryLocation W24133096281 @default.
- W2413309628 hasRelatedWork W1522936734 @default.
- W2413309628 hasRelatedWork W1978382373 @default.
- W2413309628 hasRelatedWork W2024440853 @default.
- W2413309628 hasRelatedWork W2030317352 @default.
- W2413309628 hasRelatedWork W2045449242 @default.
- W2413309628 hasRelatedWork W2054408934 @default.
- W2413309628 hasRelatedWork W2092182275 @default.
- W2413309628 hasRelatedWork W2094632443 @default.
- W2413309628 hasRelatedWork W2316204874 @default.
- W2413309628 hasRelatedWork W2413309628 @default.
- W2413309628 hasVolume "66" @default.
- W2413309628 isParatext "false" @default.
- W2413309628 isRetracted "false" @default.
- W2413309628 magId "2413309628" @default.
- W2413309628 workType "article" @default.