FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413329449> ?p ?o ?g. }

• W2413329449 endingPage "468" @default.
• W2413329449 startingPage "462" @default.
• W2413329449 abstract "Characterization of particulate systems (powders) is one of the remaining scientific challenges. Evaluation of powder behaviour is often empirical and the decision-making processes are experience-based. There is a need for development of analytical instrumentation enabling more fundamental understanding of powder behaviour. Flowability and tabletability, two key factors in commercial scale manufacturing of tablets with direct compression (DC) approach, were analysed for formulations containing increasing amounts of several model active pharmaceutical ingredients (APIs). Flowability was investigated using a ring shear tester and tablets were prepared at four different compression pressures using a single punch tablet press. Thereby, a material sparing screening approach was developed to estimate the influence of APIs on behaviour of a given DC formulation. Additionally, this approach is useful for estimating the low threshold amount of API (wt%), at which the properties of an API start affecting the powder behaviour of a given formulation (API-excipient mixture). This threshold will be referred to as critical drug loading. The flowability of microcrystalline cellulose (reference grade pH 102) was used as a threshold for adequate flowability of model formulations. The threshold for tablet tensile strength was set to 2 MPa. Simultaneous visual presentation of both- flowability and tabletability were used for a fast evaluation of manufacturability of a given formulation. The results confirmed that flowability is more sensitive to drug loading than tabletability, and that the critical drug loading for a DC formulation is strongly affected by particulate properties of API. For example, decreasing the particle size of paracetamol led to rapid decrease in flowability index, whereas the tabletability was not affected." @default.
• W2413329449 created "2016-06-24" @default.
• W2413329449 creator A5011151975 @default.
• W2413329449 creator A5021353433 @default.
• W2413329449 creator A5048621205 @default.
• W2413329449 date "2016-09-01" @default.
• W2413329449 modified "2023-09-26" @default.
• W2413329449 title "Analytical method development for powder characterization: Visualization of the critical drug loading affecting the processability of a formulation for direct compression" @default.
• W2413329449 cites W1559487077 @default.
• W2413329449 cites W1786404767 @default.
• W2413329449 cites W1966923126 @default.
• W2413329449 cites W1970140347 @default.
• W2413329449 cites W1983612337 @default.
• W2413329449 cites W1989339935 @default.
• W2413329449 cites W1989566776 @default.
• W2413329449 cites W1990317198 @default.
• W2413329449 cites W1998840711 @default.
• W2413329449 cites W2009242118 @default.
• W2413329449 cites W2009401795 @default.
• W2413329449 cites W2015136749 @default.
• W2413329449 cites W2019948236 @default.
• W2413329449 cites W2021033747 @default.
• W2413329449 cites W2033045134 @default.
• W2413329449 cites W2040217299 @default.
• W2413329449 cites W2041406898 @default.
• W2413329449 cites W2041729183 @default.
• W2413329449 cites W2042426138 @default.
• W2413329449 cites W2053153816 @default.
• W2413329449 cites W2060399264 @default.
• W2413329449 cites W2065591856 @default.
• W2413329449 cites W2070101636 @default.
• W2413329449 cites W2080904581 @default.
• W2413329449 cites W2081425451 @default.
• W2413329449 cites W2081497058 @default.
• W2413329449 cites W2089216223 @default.
• W2413329449 cites W2142454834 @default.
• W2413329449 cites W2144307801 @default.
• W2413329449 cites W2144459859 @default.
• W2413329449 cites W2160566031 @default.
• W2413329449 cites W2169719955 @default.
• W2413329449 cites W2173687410 @default.
• W2413329449 cites W4251505294 @default.
• W2413329449 doi "https://doi.org/10.1016/j.jpba.2016.06.014" @default.
• W2413329449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27368089" @default.
• W2413329449 hasPublicationYear "2016" @default.
• W2413329449 type Work @default.
• W2413329449 sameAs 2413329449 @default.
• W2413329449 citedByCount "17" @default.
• W2413329449 countsByYear W24133294492017 @default.
• W2413329449 countsByYear W24133294492018 @default.
• W2413329449 countsByYear W24133294492019 @default.
• W2413329449 countsByYear W24133294492020 @default.
• W2413329449 countsByYear W24133294492021 @default.
• W2413329449 countsByYear W24133294492022 @default.
• W2413329449 crossrefType "journal-article" @default.
• W2413329449 hasAuthorship W2413329449A5011151975 @default.
• W2413329449 hasAuthorship W2413329449A5021353433 @default.
• W2413329449 hasAuthorship W2413329449A5048621205 @default.
• W2413329449 hasConcept C106186310 @default.
• W2413329449 hasConcept C112950240 @default.
• W2413329449 hasConcept C127413603 @default.
• W2413329449 hasConcept C147789679 @default.
• W2413329449 hasConcept C159985019 @default.
• W2413329449 hasConcept C178790620 @default.
• W2413329449 hasConcept C180016635 @default.
• W2413329449 hasConcept C185592680 @default.
• W2413329449 hasConcept C187530423 @default.
• W2413329449 hasConcept C192562407 @default.
• W2413329449 hasConcept C204320433 @default.
• W2413329449 hasConcept C21880701 @default.
• W2413329449 hasConcept C2777239854 @default.
• W2413329449 hasConcept C2779251873 @default.
• W2413329449 hasConcept C2779351475 @default.
• W2413329449 hasConcept C2779849058 @default.
• W2413329449 hasConcept C2780449318 @default.
• W2413329449 hasConcept C43617362 @default.
• W2413329449 hasConceptScore W2413329449C106186310 @default.
• W2413329449 hasConceptScore W2413329449C112950240 @default.
• W2413329449 hasConceptScore W2413329449C127413603 @default.
• W2413329449 hasConceptScore W2413329449C147789679 @default.
• W2413329449 hasConceptScore W2413329449C159985019 @default.
• W2413329449 hasConceptScore W2413329449C178790620 @default.
• W2413329449 hasConceptScore W2413329449C180016635 @default.
• W2413329449 hasConceptScore W2413329449C185592680 @default.
• W2413329449 hasConceptScore W2413329449C187530423 @default.
• W2413329449 hasConceptScore W2413329449C192562407 @default.
• W2413329449 hasConceptScore W2413329449C204320433 @default.
• W2413329449 hasConceptScore W2413329449C21880701 @default.
• W2413329449 hasConceptScore W2413329449C2777239854 @default.
• W2413329449 hasConceptScore W2413329449C2779251873 @default.
• W2413329449 hasConceptScore W2413329449C2779351475 @default.
• W2413329449 hasConceptScore W2413329449C2779849058 @default.
• W2413329449 hasConceptScore W2413329449C2780449318 @default.
• W2413329449 hasConceptScore W2413329449C43617362 @default.
• W2413329449 hasLocation W24133294491 @default.
• W2413329449 hasLocation W24133294492 @default.
• W2413329449 hasOpenAccess W2413329449 @default.
• W2413329449 hasPrimaryLocation W24133294491 @default.

• next