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- W2413337811 abstract "St. John's wort, an herbal treatment for depression, should not be combined with certain drugs, including some antiretrovirals. St. John's wort can speed up the body's elimination of some drugs. When HIV medications are used, blood levels could drop low enough to allow resistance to occur. So far, St. John's wort has been tested only with the protease inhibitor indinavir (Crixivan), but it is likely to affect other drugs in that class and possibly non-nucleoside reverse transcriptase inhibitors. This warning follows a study by the National Institutes of Health (NIH) on dosing and blood levels of indinavir in HIV-negative test subjects. More information on the study is available on The Lancet's Web site. The text of the FDA's advisory letter is included." @default.
- W2413337811 created "2016-06-24" @default.
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- W2413337811 date "2000-02-18" @default.
- W2413337811 modified "2023-09-23" @default.
- W2413337811 title "St. John's wort warning: do not combine with protease inhibitors, NNRTIs." @default.
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