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• W2413339907 abstract "The human mitochondrial genome (see Fig. 1) is a 16,569-bp (base pair) circle of double-stranded DNA (1). It contains genes encoding 2 ribosomal RNAs, 22 transfer RNAs, and 13 structural genes, all of which are subunits of the respiratory chain complexes. Of the 13 structural genes, 7 encode subunits of complex I (NADH-CoQ oxidoreductase), 1 encodes the cytochrome-b subunit of complex III (CoQ-cytochrome-c oxidoreductase), 3 encode subunits of complex IV (cytochrome-c oxidase, or COX), and 2 encode subunits of complex V (ATP synthase). Each of these complexes also contains subunits encoded by nuclear genes, which are imported from the cytoplasm and assembled, together with the mtDNA-encoded subunits, into the respective holoenzymes, which are embedded in the mitochondrial inner membrane. Complex II (succinate dehydrogenase-CoQ oxidoreductase), of which succinate dehydrogenase (SDH) is a component, is encoded entirely by nuclear genes." @default.
• W2413339907 created "2016-06-24" @default.
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• W2413339907 date "2003-11-14" @default.
• W2413339907 modified "2023-09-27" @default.
• W2413339907 title "Identification of Mutations in mtDNA from Patients Suffering Mitochondrial Diseases" @default.
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• W2413339907 doi "https://doi.org/10.1385/1-59259-284-8:055" @default.
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