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- W2413408906 abstract "Scirrhous gastric carcinoma is characterized by a marked deposition of collagen in the stroma and has a very poor prognosis.To elucidate the fibrotic mechanism in scirrhous gastric carcinoma, we measured the activities of the collagen synthetic enzyme, prolyl 4-hydroxylase (P4H) and the collagen degrading enzymes, interstitial collagenase and type IV collagenase, in tissue from patients with advanced gastric carcinoma. Concentrations of P4H and tissue inhibitor of metalloproteinases-1 (TIMP-1) in the sera of patients with gastric carcinoma were measured using sandwich enzyme immunoassay systems. We performed immunohistochemical analysis for TIMP-1.Enzyme activities of P4H, interstitial collagenase and type IV collagenase in the tumor samples of scirrhous gastric carcinoma were significantly lower than those of non-scirrhous gastric carcinoma (p < 0.01). Serum concentration of TIMP-1 in patients with diffuse type carcinoma was significantly higher than in patients with intestinal type carcinoma and control subjects (p < 0.05). We demonstrated stromal expression of TIMP-1 in scirrhous gastric carcinoma tissue.These data suggest that decreased collagenase activity and increased expression of TIMP-1 would result in collagen deposition in scirrhous gastric carcinoma tissue." @default.
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- W2413408906 date "2001-02-24" @default.
- W2413408906 modified "2023-09-23" @default.
- W2413408906 title "Desmoplastic response in scirrhous gastric carcinoma: imbalance between collagen synthesis and degradation." @default.
- W2413408906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11205209" @default.
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