FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413447781> ?p ?o ?g. }

• W2413447781 endingPage "31" @default.
• W2413447781 startingPage "319" @default.
• W2413447781 abstract "Protection of infant mice against experimental E. coli B41 diarrhoea by immunization of the mothers with homologous E. coli strain was studied. The influence of the number, dose, route and moment of vaccination(s) on protection, measured by the reduced mortality rate of infant mice during the 15 days following oral challenge, was tested. The highest dose of vaccine, namely 10(8) formalin-killed E. coli by parenteral routes or 3 X 10(9) live E. coli by peroral (p.o.) route resulted in the best effect, whatever the immunization procedure used. A single vaccination of the mothers mainly delayed death without marked reduction of the mortality rate. Subcutaneous (s.c.) immunization with 10(8) formalin-killed E. coli was nevertheless more efficient than p.o. vaccination with 3 X 10(8) live E. coli. Equal levels of protection were observed when the above s.c. vaccination occurred either 15 days before the onset of gestation or on the 8th day or 15th day. In contrast, the p.o. immunization resulted in no effect when done on the 15th day of gestation. Great improvement in protection was obtained with two vaccinations, when priming occurred 15 days before the onset of gestation and boosting on the 8th day, except with two combined p.o. vaccinations with 3 X 10(8) live E. coli. Both dosages of priming and boosting seemed to matter. Peroral, subcutaneous or intraperitoneal priming with about 10(8) E. coli resulted in nearly equal effects, when boosting occurred subcutaneously with 10(8) killed E. coli. However, i.p. priming probably resulted in some non-specific effect, as shown by the slower clinical evolution of the controls. A tenfold dosage increase in p.o. priming alone led to the best protective effect observed when boosting was done three weeks after priming. The occurrence of s.c. boosting one week later, namely four weeks after priming, markedly improved protection with every route tested, and more particularly with the s.c. one. However, complete protection was never obtained. Protective effect was mostly transmitted after birth by the colostrum and the milk of the immune mothers, as demonstrated by cross-fostering experiments. Using the best immunization procedures, variability of the model was studied, by repeating experiments several times. Clinical evolution of the controls was very similar from one experiment to another, whatever the route and the moment of immunizations. In contrast, vaccinated groups showed variations which increased with time, especially on and after seven days following inoculation. Clinical evolution of individual litters belonging to the same experimental group indicated that each mother did not equally respond to the vaccination." @default.
• W2413447781 created "2016-06-24" @default.
• W2413447781 creator A5052575223 @default.
• W2413447781 date "1983-01-01" @default.
• W2413447781 modified "2023-10-16" @default.
• W2413447781 title "Infant mouse model of E. coli diarrhoea: clinical protection induced by vaccination of the mothers." @default.
• W2413447781 cites W1534411151 @default.
• W2413447781 cites W1545424419 @default.
• W2413447781 cites W1591782996 @default.
• W2413447781 cites W1870700125 @default.
• W2413447781 cites W1880955708 @default.
• W2413447781 cites W1945561518 @default.
• W2413447781 cites W1946990273 @default.
• W2413447781 cites W1949901456 @default.
• W2413447781 cites W1952444293 @default.
• W2413447781 cites W1976580656 @default.
• W2413447781 cites W1990822316 @default.
• W2413447781 cites W1992208332 @default.
• W2413447781 cites W2006311635 @default.
• W2413447781 cites W2008942471 @default.
• W2413447781 cites W2012783707 @default.
• W2413447781 cites W2015376750 @default.
• W2413447781 cites W2015722796 @default.
• W2413447781 cites W2074141045 @default.
• W2413447781 cites W2088966739 @default.
• W2413447781 cites W2104536628 @default.
• W2413447781 cites W2105039530 @default.
• W2413447781 cites W2107241243 @default.
• W2413447781 cites W2113540628 @default.
• W2413447781 cites W2135661930 @default.
• W2413447781 cites W2143487801 @default.
• W2413447781 cites W2152317730 @default.
• W2413447781 cites W2153628010 @default.
• W2413447781 cites W2182382000 @default.
• W2413447781 cites W2279872424 @default.
• W2413447781 cites W2404377259 @default.
• W2413447781 cites W2412216999 @default.
• W2413447781 cites W2412452727 @default.
• W2413447781 cites W2413862944 @default.
• W2413447781 cites W2414609042 @default.
• W2413447781 cites W2414734570 @default.
• W2413447781 cites W2415654672 @default.
• W2413447781 cites W2464832688 @default.
• W2413447781 cites W90132826 @default.
• W2413447781 cites W2411888245 @default.
• W2413447781 cites W2412724802 @default.
• W2413447781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6362544" @default.
• W2413447781 hasPublicationYear "1983" @default.
• W2413447781 type Work @default.
• W2413447781 sameAs 2413447781 @default.
• W2413447781 citedByCount "3" @default.
• W2413447781 countsByYear W24134477812018 @default.
• W2413447781 crossrefType "journal-article" @default.
• W2413447781 hasAuthorship W2413447781A5052575223 @default.
• W2413447781 hasBestOaLocation W24134477811 @default.
• W2413447781 hasConcept C100701293 @default.
• W2413447781 hasConcept C126322002 @default.
• W2413447781 hasConcept C159654299 @default.
• W2413447781 hasConcept C162156334 @default.
• W2413447781 hasConcept C203014093 @default.
• W2413447781 hasConcept C22070199 @default.
• W2413447781 hasConcept C2779234561 @default.
• W2413447781 hasConcept C2780801004 @default.
• W2413447781 hasConcept C46973012 @default.
• W2413447781 hasConcept C54355233 @default.
• W2413447781 hasConcept C59822182 @default.
• W2413447781 hasConcept C71924100 @default.
• W2413447781 hasConcept C81444415 @default.
• W2413447781 hasConcept C86803240 @default.
• W2413447781 hasConceptScore W2413447781C100701293 @default.
• W2413447781 hasConceptScore W2413447781C126322002 @default.
• W2413447781 hasConceptScore W2413447781C159654299 @default.
• W2413447781 hasConceptScore W2413447781C162156334 @default.
• W2413447781 hasConceptScore W2413447781C203014093 @default.
• W2413447781 hasConceptScore W2413447781C22070199 @default.
• W2413447781 hasConceptScore W2413447781C2779234561 @default.
• W2413447781 hasConceptScore W2413447781C2780801004 @default.
• W2413447781 hasConceptScore W2413447781C46973012 @default.
• W2413447781 hasConceptScore W2413447781C54355233 @default.
• W2413447781 hasConceptScore W2413447781C59822182 @default.
• W2413447781 hasConceptScore W2413447781C71924100 @default.
• W2413447781 hasConceptScore W2413447781C81444415 @default.
• W2413447781 hasConceptScore W2413447781C86803240 @default.
• W2413447781 hasIssue "3" @default.
• W2413447781 hasLocation W24134477811 @default.
• W2413447781 hasLocation W24134477812 @default.
• W2413447781 hasOpenAccess W2413447781 @default.
• W2413447781 hasPrimaryLocation W24134477811 @default.
• W2413447781 hasRelatedWork W1494996430 @default.
• W2413447781 hasRelatedWork W1978572420 @default.
• W2413447781 hasRelatedWork W2005049533 @default.
• W2413447781 hasRelatedWork W2072200001 @default.
• W2413447781 hasRelatedWork W2154481606 @default.
• W2413447781 hasRelatedWork W2435690523 @default.
• W2413447781 hasRelatedWork W2962682510 @default.
• W2413447781 hasRelatedWork W2982106016 @default.
• W2413447781 hasRelatedWork W2989482068 @default.
• W2413447781 hasRelatedWork W979319891 @default.

• next