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- W2413461131 abstract "An absence of gene(s) on the Rb locus of chromosome 13 or a disturbance of its normal expression in the retinoblasts of the embryonic retina predisposes an individual to the development of retinoblastoma. Chromosome aberrations involving 13q14 comprised about 14% of newly arising germinal mutations. Chromosome analysis of retinoblastoma tumor cells revealed that the generation of an extra copy of the long arm of chromosome 1 or the short arm of chromosome 6 is an early event in many of the tumors and plays a significant role in engendering tumorigenicity of retinoblasts already having one mutation at the Rb locus." @default.
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- W2413461131 date "1986-03-01" @default.
- W2413461131 modified "2023-09-23" @default.
- W2413461131 title "[Hereditary tumors and chromosome aberrations with special reference to retinoblastoma]." @default.
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- W2413461131 hasPublicationYear "1986" @default.
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