FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413503844> ?p ?o ?g. }

• W2413503844 endingPage "919" @default.
• W2413503844 startingPage "911" @default.
• W2413503844 abstract "BACKGROUND Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) is highly lethal. In a nonsurvival model of TBI + HS, addition of high-dose valproic acid (VPA) (300 mg/kg) to hetastarch reduced brain lesion size and associated swelling 6 hours after injury; whether this would have translated into better neurologic outcomes remains unknown. It is also unclear whether lower doses of VPA would be neuroprotective. We hypothesized that addition of low-dose VPA to normal saline (NS) resuscitation would result in improved long-term neurologic recovery and decreased brain lesion size. METHODS TBI was created in anesthetized swine (40–43 kg) by controlled cortical impact, and volume-controlled hemorrhage (40% volume) was induced concurrently. After 2 hours of shock, animals were randomized (n = 5 per group) to NS (3× shed blood) or NS + VPA (150 mg/kg). Six hours after resuscitation, packed red blood cells were transfused, and animals were recovered. Peripheral blood mononuclear cells were analyzed for acetylated histone-H3 at lysine-9. A Neurological Severity Score (NSS) was assessed daily for 30 days. Brain magnetic resonance imaging was performed on Days 3 and 10. Cognitive performance was assessed by training animals to retrieve food from color-coded boxes. RESULTS There was a significant increase in histone acetylation in the NS + VPA–treated animals compared with NS treatment. The NS + VPA group demonstrated significantly decreased neurologic impairment and faster speed of recovery as well as smaller brain lesion size compared with the NS group. Although the final cognitive function scores were similar between the groups, the VPA-treated animals reached the goal significantly faster than the NS controls. CONCLUSION In this long-term survival model of TBI + HS, addition of low-dose VPA to saline resuscitation resulted in attenuated neurologic impairment, faster neurologic recovery, smaller brain lesion size, and a quicker normalization of cognitive functions." @default.
• W2413503844 created "2016-06-24" @default.
• W2413503844 creator A5019012228 @default.
• W2413503844 creator A5025741593 @default.
• W2413503844 creator A5031136904 @default.
• W2413503844 creator A5032642797 @default.
• W2413503844 creator A5054859377 @default.
• W2413503844 creator A5056273184 @default.
• W2413503844 creator A5058961918 @default.
• W2413503844 creator A5062875328 @default.
• W2413503844 creator A5066941695 @default.
• W2413503844 creator A5076726145 @default.
• W2413503844 creator A5091299001 @default.
• W2413503844 date "2015-12-01" @default.
• W2413503844 modified "2023-10-09" @default.
• W2413503844 title "Addition of low-dose valproic acid to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined traumatic brain injury and hemorrhagic shock" @default.
• W2413503844 cites W1664160377 @default.
• W2413503844 cites W1737750271 @default.
• W2413503844 cites W1972373938 @default.
• W2413503844 cites W1972723234 @default.
• W2413503844 cites W1974597515 @default.
• W2413503844 cites W1975013606 @default.
• W2413503844 cites W1980288403 @default.
• W2413503844 cites W1989713634 @default.
• W2413503844 cites W1991634993 @default.
• W2413503844 cites W1995770917 @default.
• W2413503844 cites W1997267372 @default.
• W2413503844 cites W1998524597 @default.
• W2413503844 cites W2003890250 @default.
• W2413503844 cites W2005675003 @default.
• W2413503844 cites W2008412332 @default.
• W2413503844 cites W2015474429 @default.
• W2413503844 cites W2017119427 @default.
• W2413503844 cites W2019304821 @default.
• W2413503844 cites W2020440507 @default.
• W2413503844 cites W2031420349 @default.
• W2413503844 cites W2031568655 @default.
• W2413503844 cites W2042341137 @default.
• W2413503844 cites W2053770990 @default.
• W2413503844 cites W2057881500 @default.
• W2413503844 cites W2068344204 @default.
• W2413503844 cites W2084962044 @default.
• W2413503844 cites W2086857869 @default.
• W2413503844 cites W2086891666 @default.
• W2413503844 cites W2087155042 @default.
• W2413503844 cites W2093096410 @default.
• W2413503844 cites W2094977194 @default.
• W2413503844 cites W2108003465 @default.
• W2413503844 cites W2109115714 @default.
• W2413503844 cites W2115769793 @default.
• W2413503844 cites W2119543650 @default.
• W2413503844 cites W2121836743 @default.
• W2413503844 cites W2142717775 @default.
• W2413503844 cites W2146762894 @default.
• W2413503844 cites W2322211964 @default.
• W2413503844 cites W2324514343 @default.
• W2413503844 cites W2327130831 @default.
• W2413503844 cites W2600339308 @default.
• W2413503844 doi "https://doi.org/10.1097/ta.0000000000000789" @default.
• W2413503844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26680134" @default.
• W2413503844 hasPublicationYear "2015" @default.
• W2413503844 type Work @default.
• W2413503844 sameAs 2413503844 @default.
• W2413503844 citedByCount "52" @default.
• W2413503844 countsByYear W24135038442015 @default.
• W2413503844 countsByYear W24135038442016 @default.
• W2413503844 countsByYear W24135038442017 @default.
• W2413503844 countsByYear W24135038442018 @default.
• W2413503844 countsByYear W24135038442019 @default.
• W2413503844 countsByYear W24135038442020 @default.
• W2413503844 countsByYear W24135038442021 @default.
• W2413503844 countsByYear W24135038442022 @default.
• W2413503844 countsByYear W24135038442023 @default.
• W2413503844 crossrefType "journal-article" @default.
• W2413503844 hasAuthorship W2413503844A5019012228 @default.
• W2413503844 hasAuthorship W2413503844A5025741593 @default.
• W2413503844 hasAuthorship W2413503844A5031136904 @default.
• W2413503844 hasAuthorship W2413503844A5032642797 @default.
• W2413503844 hasAuthorship W2413503844A5054859377 @default.
• W2413503844 hasAuthorship W2413503844A5056273184 @default.
• W2413503844 hasAuthorship W2413503844A5058961918 @default.
• W2413503844 hasAuthorship W2413503844A5062875328 @default.
• W2413503844 hasAuthorship W2413503844A5066941695 @default.
• W2413503844 hasAuthorship W2413503844A5076726145 @default.
• W2413503844 hasAuthorship W2413503844A5091299001 @default.
• W2413503844 hasConcept C118552586 @default.
• W2413503844 hasConcept C126322002 @default.
• W2413503844 hasConcept C141071460 @default.
• W2413503844 hasConcept C25498285 @default.
• W2413503844 hasConcept C2777172819 @default.
• W2413503844 hasConcept C2777397205 @default.
• W2413503844 hasConcept C2778165595 @default.
• W2413503844 hasConcept C2778186239 @default.
• W2413503844 hasConcept C2781017439 @default.
• W2413503844 hasConcept C2781156865 @default.
• W2413503844 hasConcept C2781458332 @default.
• W2413503844 hasConcept C42219234 @default.
• W2413503844 hasConcept C71924100 @default.

• next