Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413550229> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2413550229 endingPage "338" @default.
- W2413550229 startingPage "335" @default.
- W2413550229 abstract "Objective To observethe effects of Genistein on TGF-β1 expression and the intracellular free Ca2+ concentration in human hyperu'ophic scar fibroblasts,and to discuss the mechanism of the anti-fibrosis effect.Methods Fibroblasts were derired from human hypertrophic scar tissue and cultured in vitro.Genistein in different concentrations(25、50、100 μmol/L)was administrated to the fibmblasts,respectively.After 48 hours of co-culture,the expression of TGF-β1 mBNA and protein were examined by RT-PCR and Western-Blot assay respectively.The intracetlular free Ca2+ concentration in hypertrophic gear fibmblasts pretreated by Genistein was determined by laser confocal scanning microscopy with or without the stimulation of bFGF.Results Genistein inhibited the expression of TGF-β1 in hypertrophic scar fibroblasts on a concentration-dependent manner.bFGF significantly elevated the intracellular free Ca2+ concentration.however its stimulating effect was remarkably alleviated when the flbroblasts were pro-treated by Genistein.Conclusions Genistein can reduce the expression of TCF-β1 and block the accumulation of intmcellular free calcium induced by growth factors.It maybe one of the possible mechanisms of Genistein's antifibrosis effect.Key words: Genistein; Scar; Transforming grounth factor-β1; Ca2+" @default.
- W2413550229 created "2016-06-24" @default.
- W2413550229 creator A5032752009 @default.
- W2413550229 creator A5036688786 @default.
- W2413550229 creator A5038102805 @default.
- W2413550229 creator A5040773949 @default.
- W2413550229 creator A5043366101 @default.
- W2413550229 creator A5051115285 @default.
- W2413550229 creator A5053780153 @default.
- W2413550229 date "2008-09-01" @default.
- W2413550229 modified "2023-09-25" @default.
- W2413550229 title "[Effects of genistein on expression of TGF-beta1 and intracellular free Ca2+ concentration in fibroblasts derived from human hypertrophic scar]." @default.
- W2413550229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19119629" @default.
- W2413550229 hasPublicationYear "2008" @default.
- W2413550229 type Work @default.
- W2413550229 sameAs 2413550229 @default.
- W2413550229 citedByCount "0" @default.
- W2413550229 crossrefType "journal-article" @default.
- W2413550229 hasAuthorship W2413550229A5032752009 @default.
- W2413550229 hasAuthorship W2413550229A5036688786 @default.
- W2413550229 hasAuthorship W2413550229A5038102805 @default.
- W2413550229 hasAuthorship W2413550229A5040773949 @default.
- W2413550229 hasAuthorship W2413550229A5043366101 @default.
- W2413550229 hasAuthorship W2413550229A5051115285 @default.
- W2413550229 hasAuthorship W2413550229A5053780153 @default.
- W2413550229 hasConcept C104317684 @default.
- W2413550229 hasConcept C105702510 @default.
- W2413550229 hasConcept C118131993 @default.
- W2413550229 hasConcept C126322002 @default.
- W2413550229 hasConcept C134018914 @default.
- W2413550229 hasConcept C153911025 @default.
- W2413550229 hasConcept C181080969 @default.
- W2413550229 hasConcept C185592680 @default.
- W2413550229 hasConcept C2776415932 @default.
- W2413550229 hasConcept C2778298627 @default.
- W2413550229 hasConcept C2778698245 @default.
- W2413550229 hasConcept C55493867 @default.
- W2413550229 hasConcept C71924100 @default.
- W2413550229 hasConcept C79879829 @default.
- W2413550229 hasConcept C86803240 @default.
- W2413550229 hasConceptScore W2413550229C104317684 @default.
- W2413550229 hasConceptScore W2413550229C105702510 @default.
- W2413550229 hasConceptScore W2413550229C118131993 @default.
- W2413550229 hasConceptScore W2413550229C126322002 @default.
- W2413550229 hasConceptScore W2413550229C134018914 @default.
- W2413550229 hasConceptScore W2413550229C153911025 @default.
- W2413550229 hasConceptScore W2413550229C181080969 @default.
- W2413550229 hasConceptScore W2413550229C185592680 @default.
- W2413550229 hasConceptScore W2413550229C2776415932 @default.
- W2413550229 hasConceptScore W2413550229C2778298627 @default.
- W2413550229 hasConceptScore W2413550229C2778698245 @default.
- W2413550229 hasConceptScore W2413550229C55493867 @default.
- W2413550229 hasConceptScore W2413550229C71924100 @default.
- W2413550229 hasConceptScore W2413550229C79879829 @default.
- W2413550229 hasConceptScore W2413550229C86803240 @default.
- W2413550229 hasIssue "5" @default.
- W2413550229 hasLocation W24135502291 @default.
- W2413550229 hasLocation W24135502292 @default.
- W2413550229 hasOpenAccess W2413550229 @default.
- W2413550229 hasPrimaryLocation W24135502291 @default.
- W2413550229 hasRelatedWork W1989689430 @default.
- W2413550229 hasRelatedWork W2166110166 @default.
- W2413550229 hasRelatedWork W2353235281 @default.
- W2413550229 hasRelatedWork W2353881330 @default.
- W2413550229 hasRelatedWork W2358094182 @default.
- W2413550229 hasRelatedWork W2360942897 @default.
- W2413550229 hasRelatedWork W2362468001 @default.
- W2413550229 hasRelatedWork W2367166553 @default.
- W2413550229 hasRelatedWork W2372797346 @default.
- W2413550229 hasRelatedWork W2377492624 @default.
- W2413550229 hasRelatedWork W2379528706 @default.
- W2413550229 hasRelatedWork W2386029884 @default.
- W2413550229 hasRelatedWork W2749624926 @default.
- W2413550229 hasRelatedWork W2979854298 @default.
- W2413550229 hasRelatedWork W3028748420 @default.
- W2413550229 hasRelatedWork W3029795748 @default.
- W2413550229 hasRelatedWork W3032086811 @default.
- W2413550229 hasRelatedWork W3084333988 @default.
- W2413550229 hasRelatedWork W3103671200 @default.
- W2413550229 hasRelatedWork W3141220180 @default.
- W2413550229 hasVolume "24" @default.
- W2413550229 isParatext "false" @default.
- W2413550229 isRetracted "false" @default.
- W2413550229 magId "2413550229" @default.
- W2413550229 workType "article" @default.