Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413551462> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2413551462 endingPage "6" @default.
- W2413551462 startingPage "3361" @default.
- W2413551462 abstract "Genetic aberrations observed in the large bowel during the neoplastic progression have a cumulative effect and are responsible for the propagation of the multistep malignant process. In the present study we evaluated the immunoreactivity of c-fos, ras, bcl-2 and p53 in aberrant crypt foci (ACF) and minute polyps of the large bowel obtained from patients with colorectal cancer.ACF and minute polyps were collected from macroscopically normal colonic mucosa. Protein immunoreactivity was detected on parafin sections utilizing the biotin-streptavidin method on 25 hyperplastic, 10 dysplastic ACF, 5 hyperplastic and 10 dysplastic adenomas.41% of the lesions displayed positive ras immunoreactivity. bcl-2 immunoreactivity was positive in six minute polyps of which five were neoplastic. fos immunoreactivity was detected in five ACF and seven minute polyps, mainly in dysplastic lesions. Two neoplastic polyps were positive for p53 immunoreactivity. Coexpression of two or more oncoproteins was found with increasing frequency in dysplastic versus hyperplastic lesions and in polypoid lesions versus ACF.Abnormal expression and coexpression in oncoproteins can be identified in the earliest stages of colorectal tumorigenesis and may contribute to the progression of selected lesions during ACF-adenoma-carcinoma sequence." @default.
- W2413551462 created "2016-06-24" @default.
- W2413551462 creator A5000589546 @default.
- W2413551462 creator A5001069772 @default.
- W2413551462 creator A5001835367 @default.
- W2413551462 creator A5006070546 @default.
- W2413551462 creator A5049949933 @default.
- W2413551462 creator A5052405555 @default.
- W2413551462 creator A5084056456 @default.
- W2413551462 creator A5086809903 @default.
- W2413551462 date "2000-02-01" @default.
- W2413551462 modified "2023-10-16" @default.
- W2413551462 title "Oncoprotein coexpression in human aberrant crypt foci and minute polypoid lesions of the large bowel." @default.
- W2413551462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10652634" @default.
- W2413551462 hasPublicationYear "2000" @default.
- W2413551462 type Work @default.
- W2413551462 sameAs 2413551462 @default.
- W2413551462 citedByCount "1" @default.
- W2413551462 crossrefType "journal-article" @default.
- W2413551462 hasAuthorship W2413551462A5000589546 @default.
- W2413551462 hasAuthorship W2413551462A5001069772 @default.
- W2413551462 hasAuthorship W2413551462A5001835367 @default.
- W2413551462 hasAuthorship W2413551462A5006070546 @default.
- W2413551462 hasAuthorship W2413551462A5049949933 @default.
- W2413551462 hasAuthorship W2413551462A5052405555 @default.
- W2413551462 hasAuthorship W2413551462A5084056456 @default.
- W2413551462 hasAuthorship W2413551462A5086809903 @default.
- W2413551462 hasConcept C121608353 @default.
- W2413551462 hasConcept C126322002 @default.
- W2413551462 hasConcept C134018914 @default.
- W2413551462 hasConcept C142724271 @default.
- W2413551462 hasConcept C204232928 @default.
- W2413551462 hasConcept C2775894508 @default.
- W2413551462 hasConcept C2777428134 @default.
- W2413551462 hasConcept C2777562237 @default.
- W2413551462 hasConcept C2778435480 @default.
- W2413551462 hasConcept C2780669762 @default.
- W2413551462 hasConcept C2908781503 @default.
- W2413551462 hasConcept C2910035481 @default.
- W2413551462 hasConcept C3018440083 @default.
- W2413551462 hasConcept C526805850 @default.
- W2413551462 hasConcept C555283112 @default.
- W2413551462 hasConcept C66090201 @default.
- W2413551462 hasConcept C71924100 @default.
- W2413551462 hasConcept C86803240 @default.
- W2413551462 hasConceptScore W2413551462C121608353 @default.
- W2413551462 hasConceptScore W2413551462C126322002 @default.
- W2413551462 hasConceptScore W2413551462C134018914 @default.
- W2413551462 hasConceptScore W2413551462C142724271 @default.
- W2413551462 hasConceptScore W2413551462C204232928 @default.
- W2413551462 hasConceptScore W2413551462C2775894508 @default.
- W2413551462 hasConceptScore W2413551462C2777428134 @default.
- W2413551462 hasConceptScore W2413551462C2777562237 @default.
- W2413551462 hasConceptScore W2413551462C2778435480 @default.
- W2413551462 hasConceptScore W2413551462C2780669762 @default.
- W2413551462 hasConceptScore W2413551462C2908781503 @default.
- W2413551462 hasConceptScore W2413551462C2910035481 @default.
- W2413551462 hasConceptScore W2413551462C3018440083 @default.
- W2413551462 hasConceptScore W2413551462C526805850 @default.
- W2413551462 hasConceptScore W2413551462C555283112 @default.
- W2413551462 hasConceptScore W2413551462C66090201 @default.
- W2413551462 hasConceptScore W2413551462C71924100 @default.
- W2413551462 hasConceptScore W2413551462C86803240 @default.
- W2413551462 hasIssue "4B" @default.
- W2413551462 hasLocation W24135514621 @default.
- W2413551462 hasOpenAccess W2413551462 @default.
- W2413551462 hasPrimaryLocation W24135514621 @default.
- W2413551462 hasRelatedWork W1907210134 @default.
- W2413551462 hasRelatedWork W1963769095 @default.
- W2413551462 hasRelatedWork W2019781712 @default.
- W2413551462 hasRelatedWork W2031372290 @default.
- W2413551462 hasRelatedWork W2053655992 @default.
- W2413551462 hasRelatedWork W2058047917 @default.
- W2413551462 hasRelatedWork W2329197128 @default.
- W2413551462 hasRelatedWork W2398025231 @default.
- W2413551462 hasRelatedWork W2413551462 @default.
- W2413551462 hasRelatedWork W2418096788 @default.
- W2413551462 hasVolume "19" @default.
- W2413551462 isParatext "false" @default.
- W2413551462 isRetracted "false" @default.
- W2413551462 magId "2413551462" @default.
- W2413551462 workType "article" @default.