Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413573391> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2413573391 abstract "Saframycin A (SFM-A), a tetrahydroisoquinoline antibiotic isolated from Streptomyces lavendulae, shows potent anti-proliferation activities against a variety of tumor cell lines, and shares the core structure with ecteinascidin 743 (ET-743), the anticancer drug for soft-tissue sarcoma. Characterization of the SFM-A biosynthetic gene cluster revealed three nonribosomal peptide synthetase genes and a series of genes encoding oxygenases. To investigate the function of sfmO2 gene, encoding a FAD-dependent monooxygenase/hydroxylase, we constructed the gene replacement mutant (Delta sfmO2) strain S. lavendulae TL2007 and the corresponding gene complementation mutant strain S. lavendulae TL2008. A novel compound, SFM-O, was isolated from the Delta sfmO2 replacement mutant strain and its structure was characterized by comparison to the HRMS and NMR spectra of SFM-A. These findings indicated that SfmO2 is responsible for the oxidation of ring A in the biosynthetic pathway of SFM-A, and the new compound SFM-O could be considered as an advanced intermediate in the semisynthesis of ET-743." @default.
- W2413573391 created "2016-06-24" @default.
- W2413573391 creator A5003508343 @default.
- W2413573391 creator A5013850696 @default.
- W2413573391 creator A5050679750 @default.
- W2413573391 creator A5056741844 @default.
- W2413573391 creator A5062848072 @default.
- W2413573391 creator A5074604145 @default.
- W2413573391 creator A5084769565 @default.
- W2413573391 creator A5089916191 @default.
- W2413573391 date "2012-01-01" @default.
- W2413573391 modified "2023-09-23" @default.
- W2413573391 title "In vivo investigation of the role of SfmO2 in saframycin A biosynthesis by structural characterization of the analogue saframycin O" @default.
- W2413573391 hasPublicationYear "2012" @default.
- W2413573391 type Work @default.
- W2413573391 sameAs 2413573391 @default.
- W2413573391 citedByCount "0" @default.
- W2413573391 crossrefType "journal-article" @default.
- W2413573391 hasAuthorship W2413573391A5003508343 @default.
- W2413573391 hasAuthorship W2413573391A5013850696 @default.
- W2413573391 hasAuthorship W2413573391A5050679750 @default.
- W2413573391 hasAuthorship W2413573391A5056741844 @default.
- W2413573391 hasAuthorship W2413573391A5062848072 @default.
- W2413573391 hasAuthorship W2413573391A5074604145 @default.
- W2413573391 hasAuthorship W2413573391A5084769565 @default.
- W2413573391 hasAuthorship W2413573391A5089916191 @default.
- W2413573391 hasConcept C104317684 @default.
- W2413573391 hasConcept C143065580 @default.
- W2413573391 hasConcept C162776295 @default.
- W2413573391 hasConcept C185592680 @default.
- W2413573391 hasConcept C188082640 @default.
- W2413573391 hasConcept C2776406546 @default.
- W2413573391 hasConcept C2777379556 @default.
- W2413573391 hasConcept C2779920670 @default.
- W2413573391 hasConcept C36857842 @default.
- W2413573391 hasConcept C523546767 @default.
- W2413573391 hasConcept C54355233 @default.
- W2413573391 hasConcept C553450214 @default.
- W2413573391 hasConcept C55493867 @default.
- W2413573391 hasConcept C71240020 @default.
- W2413573391 hasConcept C86803240 @default.
- W2413573391 hasConceptScore W2413573391C104317684 @default.
- W2413573391 hasConceptScore W2413573391C143065580 @default.
- W2413573391 hasConceptScore W2413573391C162776295 @default.
- W2413573391 hasConceptScore W2413573391C185592680 @default.
- W2413573391 hasConceptScore W2413573391C188082640 @default.
- W2413573391 hasConceptScore W2413573391C2776406546 @default.
- W2413573391 hasConceptScore W2413573391C2777379556 @default.
- W2413573391 hasConceptScore W2413573391C2779920670 @default.
- W2413573391 hasConceptScore W2413573391C36857842 @default.
- W2413573391 hasConceptScore W2413573391C523546767 @default.
- W2413573391 hasConceptScore W2413573391C54355233 @default.
- W2413573391 hasConceptScore W2413573391C553450214 @default.
- W2413573391 hasConceptScore W2413573391C55493867 @default.
- W2413573391 hasConceptScore W2413573391C71240020 @default.
- W2413573391 hasConceptScore W2413573391C86803240 @default.
- W2413573391 hasIssue "1" @default.
- W2413573391 hasLocation W24135733911 @default.
- W2413573391 hasOpenAccess W2413573391 @default.
- W2413573391 hasPrimaryLocation W24135733911 @default.
- W2413573391 hasRelatedWork W1977277805 @default.
- W2413573391 hasRelatedWork W2000540412 @default.
- W2413573391 hasRelatedWork W2006985382 @default.
- W2413573391 hasRelatedWork W2030316332 @default.
- W2413573391 hasRelatedWork W2051560020 @default.
- W2413573391 hasRelatedWork W2052603675 @default.
- W2413573391 hasRelatedWork W2059526549 @default.
- W2413573391 hasRelatedWork W2070427734 @default.
- W2413573391 hasRelatedWork W2071750413 @default.
- W2413573391 hasRelatedWork W2097014677 @default.
- W2413573391 hasRelatedWork W2118780226 @default.
- W2413573391 hasRelatedWork W2156304765 @default.
- W2413573391 hasRelatedWork W2185950371 @default.
- W2413573391 hasRelatedWork W2255678164 @default.
- W2413573391 hasRelatedWork W2325918749 @default.
- W2413573391 hasRelatedWork W2465603102 @default.
- W2413573391 hasRelatedWork W3138441953 @default.
- W2413573391 hasRelatedWork W3151631123 @default.
- W2413573391 hasRelatedWork W3202800217 @default.
- W2413573391 hasRelatedWork W2322585025 @default.
- W2413573391 hasVolume "55" @default.
- W2413573391 isParatext "false" @default.
- W2413573391 isRetracted "false" @default.
- W2413573391 magId "2413573391" @default.
- W2413573391 workType "article" @default.