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• W2413595504 abstract "We thank Dr. Madias for his interest and thoughtful comments on our report assessing the natural history of cardiac arrest (CA) in patients diagnosed with takotsubo cardiomyopathy (TTC). 1 Singh K. Carson K. Hibbert B. Le May M. Natural history of cardiac arrest in patients with takotsubo cardiomyopathy. Am J Cardiol. 2015; 115: 1466-1472 Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar In this report, we reviewed 77 published cases of TTC complicated by CA to assess if TTC was a precipitant or a consequence of CA. Clinical characteristics of patients with “primary or typical” TTC were different from the “secondary” TTC group. Patients with typical TTC were older, had relatively longer QTc interval at the time of CA, and had polymorphic ventricular tachycardia. The underlying cause of CA in typical TTC is delayed repolarization leading to polymorphic ventricular tachycardia. We believe that in this subgroup of patients, the risk of recurrence of CA is extremely rare because the risk of TTC recurrence itself is 3% to 5%. 2 Singh K. Carson K. Usmani Z. Sawhney G. Shah R. Horowitz J. Systematic review and meta-analysis of incidence and correlates of recurrence of takotsubo cardiomyopathy. Int J Cardiol. 2014; 174: 696-701 Abstract Full Text Full Text PDF PubMed Scopus (155) Google Scholar In contrast, the etiology of CA in patients with secondary TTC is not that clear. This subgroup of patients appears to comprise subjects who either had TTC and experienced a CA in the very acute phase of their illness or had a CA because of non–TTC-related cardiac cause and, after resuscitation, developed TTC. Cardiac Arrest in Patients Before and After the Inception of Takotsubo SyndromeAmerican Journal of CardiologyVol. 115Issue 12PreviewThe report by Singh et al,1 published online ahead of print on February 18, 2015, in The American Journal of Cardiology, about cardiac arrest (CA) and takotsubo syndrome (TTS), provides a lot of food for thought! The key point is whether TTS was the precipitant or the consequence of CA, in the 77 patients whom the investigators reported. The 17 patients (primary TTS) who had CA after the diagnosis of TTS were older by a mean of 15 years than subgroup B, and who subsequently developed longer corrected QT interval, and TTS-induced polymorphic ventricular tachycardia, represent the “classic” TTS subgroup, who had CA in the subacute phase of the illness. Full-Text PDF" @default.
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• W2413595504 date "2015-06-01" @default.
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• W2413595504 doi "https://doi.org/10.1016/j.amjcard.2015.04.004" @default.
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