Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413601437> ?p ?o ?g. }
- W2413601437 abstract "Abstract Long-term high-fat diet (HFD) consumption leads to not only obese-insulin resistance, but also impaired left ventricular (LV) function. Vagus nerve stimulation (VNS) has been shown to exert cardioprotection. However, its effects on the heart and metabolic parameters under obese-insulin resistant condition is not known. We determined the effects of VNS on metabolic parameters, heart rate variability (HRV) and LV function in obese-insulin resistant rats. Male Wistar rats were fed with HFD for 12 weeks and were randomly divided into sham and VNS groups. VNS was applied for the next 12 weeks. Echocardiography, blood pressure and HRV were examined. Blood samples were collected for metabolic parameters. At the end, the heart was removed for determination of apoptosis, inflammation, oxidative stress and cardiac mitochondrial function. VNS for 12 weeks significantly decreased plasma insulin, HOMA index, total cholesterol, triglyceride, LDL and visceral fat. Serum adiponectin was significantly increased in the VNS group. VNS also significantly decreased blood pressure, improved HRV and LV function, decreased cardiac MDA, TNF-α and Bax levels and improved cardiac mitochondrial function. VNS improves metabolic and hemodynamic parameters and the LV function via its ability against apoptosis, inflammation and oxidative stress and preserved cardiac mitochondrial function in obese-insulin resistant rats." @default.
- W2413601437 created "2016-06-24" @default.
- W2413601437 creator A5008481948 @default.
- W2413601437 creator A5025939163 @default.
- W2413601437 creator A5030219645 @default.
- W2413601437 creator A5045398840 @default.
- W2413601437 creator A5050799790 @default.
- W2413601437 creator A5064788311 @default.
- W2413601437 creator A5078029455 @default.
- W2413601437 date "2016-02-01" @default.
- W2413601437 modified "2023-10-18" @default.
- W2413601437 title "Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats" @default.
- W2413601437 cites W1601746604 @default.
- W2413601437 cites W1787584394 @default.
- W2413601437 cites W1917440656 @default.
- W2413601437 cites W1970608488 @default.
- W2413601437 cites W1972009831 @default.
- W2413601437 cites W1972468792 @default.
- W2413601437 cites W1974033843 @default.
- W2413601437 cites W1980964357 @default.
- W2413601437 cites W1983534040 @default.
- W2413601437 cites W1986276307 @default.
- W2413601437 cites W1999626957 @default.
- W2413601437 cites W2001306967 @default.
- W2413601437 cites W2009067533 @default.
- W2413601437 cites W2016454497 @default.
- W2413601437 cites W2017602185 @default.
- W2413601437 cites W2024024691 @default.
- W2413601437 cites W2024515089 @default.
- W2413601437 cites W2024733689 @default.
- W2413601437 cites W2026014239 @default.
- W2413601437 cites W2032627403 @default.
- W2413601437 cites W2036608397 @default.
- W2413601437 cites W2037825828 @default.
- W2413601437 cites W2039331237 @default.
- W2413601437 cites W2042706232 @default.
- W2413601437 cites W2048034841 @default.
- W2413601437 cites W2057745875 @default.
- W2413601437 cites W2062829364 @default.
- W2413601437 cites W2072206476 @default.
- W2413601437 cites W2081965230 @default.
- W2413601437 cites W2082089391 @default.
- W2413601437 cites W2086673416 @default.
- W2413601437 cites W2094164338 @default.
- W2413601437 cites W2098814645 @default.
- W2413601437 cites W2104041304 @default.
- W2413601437 cites W2107865201 @default.
- W2413601437 cites W2116404316 @default.
- W2413601437 cites W2120688902 @default.
- W2413601437 cites W2120723181 @default.
- W2413601437 cites W2122638636 @default.
- W2413601437 cites W2126945908 @default.
- W2413601437 cites W2127265634 @default.
- W2413601437 cites W2130495917 @default.
- W2413601437 cites W2132877097 @default.
- W2413601437 cites W2134943326 @default.
- W2413601437 cites W2137441166 @default.
- W2413601437 cites W2144097140 @default.
- W2413601437 cites W2148923211 @default.
- W2413601437 cites W2158060605 @default.
- W2413601437 cites W4252910375 @default.
- W2413601437 doi "https://doi.org/10.1038/srep19749" @default.
- W2413601437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4735283" @default.
- W2413601437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26830020" @default.
- W2413601437 hasPublicationYear "2016" @default.
- W2413601437 type Work @default.
- W2413601437 sameAs 2413601437 @default.
- W2413601437 citedByCount "38" @default.
- W2413601437 countsByYear W24136014372016 @default.
- W2413601437 countsByYear W24136014372017 @default.
- W2413601437 countsByYear W24136014372018 @default.
- W2413601437 countsByYear W24136014372019 @default.
- W2413601437 countsByYear W24136014372020 @default.
- W2413601437 countsByYear W24136014372021 @default.
- W2413601437 countsByYear W24136014372022 @default.
- W2413601437 countsByYear W24136014372023 @default.
- W2413601437 crossrefType "journal-article" @default.
- W2413601437 hasAuthorship W2413601437A5008481948 @default.
- W2413601437 hasAuthorship W2413601437A5025939163 @default.
- W2413601437 hasAuthorship W2413601437A5030219645 @default.
- W2413601437 hasAuthorship W2413601437A5045398840 @default.
- W2413601437 hasAuthorship W2413601437A5050799790 @default.
- W2413601437 hasAuthorship W2413601437A5064788311 @default.
- W2413601437 hasAuthorship W2413601437A5078029455 @default.
- W2413601437 hasBestOaLocation W24136014371 @default.
- W2413601437 hasConcept C111566952 @default.
- W2413601437 hasConcept C126322002 @default.
- W2413601437 hasConcept C134018914 @default.
- W2413601437 hasConcept C24998067 @default.
- W2413601437 hasConcept C2776151105 @default.
- W2413601437 hasConcept C2776782570 @default.
- W2413601437 hasConcept C2777391703 @default.
- W2413601437 hasConcept C2777953023 @default.
- W2413601437 hasConcept C2778163477 @default.
- W2413601437 hasConcept C2778198053 @default.
- W2413601437 hasConcept C2778913445 @default.
- W2413601437 hasConcept C2779306644 @default.
- W2413601437 hasConcept C2779676291 @default.
- W2413601437 hasConcept C2780087125 @default.
- W2413601437 hasConcept C2781404750 @default.