FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413602913> ?p ?o ?g. }

• W2413602913 endingPage "141" @default.
• W2413602913 startingPage "130" @default.
• W2413602913 abstract "Evidence for immune/neuroimmune disturbances as a possible root cause of a range of disorders, including neurodevelopmental disorders, is growing. Although prenatal alcohol exposure (PAE) impacts immune function, few studies to date have examined immune function in relation to long-term negative health outcomes following PAE, and most have focused on males. To fill this gap, we utilized a rat model to examine the effects of PAE on immune/neuroimmune function during early-life [postnatal day 1 (P1), P8, and P22] in PAE and control females. Due to the extensive interplay between the immune and endocrine systems, we also measured levels of corticosterone and corticosterone binding globulin (CBG). While corticosterone levels were not different among groups, CBG levels were lower in PAE offspring from P1 to P8, suggesting a lower corticosterone reservoir that may underlie susceptibility to inflammation. Spleen weights were increased in PAE rats on P22, a marker of altered immune function. Moreover, we detected a unique cytokine profile in PAE compared to control offspring on P8 – higher levels in the PFC and hippocampus, and lower levels in the hypothalamus and spleen. The finding of a specific immune signature in PAE offspring during a sensitive developmental period has important implications for understanding the basis of long-term immune alterations and health outcomes in children with Fetal Alcohol Spectrum Disorder (FASD). Our findings also highlight the future possibility that immune-based intervention strategies could be considered as an adjunctive novel therapeutic approach for individuals with FASD." @default.
• W2413602913 created "2016-06-24" @default.
• W2413602913 creator A5010143483 @default.
• W2413602913 creator A5037987356 @default.
• W2413602913 creator A5056956604 @default.
• W2413602913 date "2016-11-01" @default.
• W2413602913 modified "2023-10-01" @default.
• W2413602913 title "Evidence for an immune signature of prenatal alcohol exposure in female rats" @default.
• W2413602913 cites W1409858176 @default.
• W2413602913 cites W1487018400 @default.
• W2413602913 cites W1592416862 @default.
• W2413602913 cites W1725804876 @default.
• W2413602913 cites W1747288921 @default.
• W2413602913 cites W1842467494 @default.
• W2413602913 cites W1858299364 @default.
• W2413602913 cites W1858878923 @default.
• W2413602913 cites W1965661602 @default.
• W2413602913 cites W1967761338 @default.
• W2413602913 cites W1969866098 @default.
• W2413602913 cites W1972534078 @default.
• W2413602913 cites W1973564045 @default.
• W2413602913 cites W1974034780 @default.
• W2413602913 cites W1980318702 @default.
• W2413602913 cites W1981149106 @default.
• W2413602913 cites W1983509256 @default.
• W2413602913 cites W1987375729 @default.
• W2413602913 cites W1993558760 @default.
• W2413602913 cites W1997422264 @default.
• W2413602913 cites W2001214757 @default.
• W2413602913 cites W2006581218 @default.
• W2413602913 cites W2007655172 @default.
• W2413602913 cites W2014523798 @default.
• W2413602913 cites W2016995746 @default.
• W2413602913 cites W2018440098 @default.
• W2413602913 cites W2025392129 @default.
• W2413602913 cites W2028254433 @default.
• W2413602913 cites W2036227124 @default.
• W2413602913 cites W2036608908 @default.
• W2413602913 cites W2039412948 @default.
• W2413602913 cites W2039719578 @default.
• W2413602913 cites W2040971572 @default.
• W2413602913 cites W2042207199 @default.
• W2413602913 cites W2044014117 @default.
• W2413602913 cites W2045768996 @default.
• W2413602913 cites W2049079854 @default.
• W2413602913 cites W2051185092 @default.
• W2413602913 cites W2053925035 @default.
• W2413602913 cites W2061798311 @default.
• W2413602913 cites W2062825661 @default.
• W2413602913 cites W2063299997 @default.
• W2413602913 cites W2064564930 @default.
• W2413602913 cites W2064891273 @default.
• W2413602913 cites W2065341503 @default.
• W2413602913 cites W2067226625 @default.
• W2413602913 cites W2073047972 @default.
• W2413602913 cites W2081254307 @default.
• W2413602913 cites W2085214508 @default.
• W2413602913 cites W2089727463 @default.
• W2413602913 cites W2090861392 @default.
• W2413602913 cites W2091287922 @default.
• W2413602913 cites W2092416261 @default.
• W2413602913 cites W2096180213 @default.
• W2413602913 cites W2101717948 @default.
• W2413602913 cites W2104387367 @default.
• W2413602913 cites W2105469110 @default.
• W2413602913 cites W2111426554 @default.
• W2413602913 cites W2112818206 @default.
• W2413602913 cites W2119040178 @default.
• W2413602913 cites W2119817049 @default.
• W2413602913 cites W2120701088 @default.
• W2413602913 cites W2122037893 @default.
• W2413602913 cites W2122460606 @default.
• W2413602913 cites W2122651593 @default.
• W2413602913 cites W2124859215 @default.
• W2413602913 cites W2132501470 @default.
• W2413602913 cites W2134836294 @default.
• W2413602913 cites W2136854370 @default.
• W2413602913 cites W2137386978 @default.
• W2413602913 cites W2138463718 @default.
• W2413602913 cites W2142872367 @default.
• W2413602913 cites W2153298256 @default.
• W2413602913 cites W2154698170 @default.
• W2413602913 cites W2154965665 @default.
• W2413602913 cites W2159086316 @default.
• W2413602913 cites W2161295804 @default.
• W2413602913 cites W2163759450 @default.
• W2413602913 cites W2170899083 @default.
• W2413602913 cites W2194203357 @default.
• W2413602913 cites W2220554922 @default.
• W2413602913 cites W2315937070 @default.
• W2413602913 cites W2399424635 @default.
• W2413602913 cites W2411789234 @default.
• W2413602913 cites W4232636542 @default.
• W2413602913 cites W4248065725 @default.
• W2413602913 doi "https://doi.org/10.1016/j.bbi.2016.05.022" @default.
• W2413602913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5067180" @default.
• W2413602913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27263429" @default.
• W2413602913 hasPublicationYear "2016" @default.

• next