Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413618897> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2413618897 endingPage "43" @default.
- W2413618897 startingPage "839" @default.
- W2413618897 abstract "Impulse noise was adopted in adult rats to built acute deafferent animal model. Differential proteomics techniques were applied to detect the changes of protein expression in the auditory cortex before and after the noise exposure.Thirty adult SD rats were divided into three groups: normal group, rats with acute noise exposure and rats 28 days recovery after noise exposure (n=10/group). All animals were exposed to impulse noise at 156 dB for 50 pulses with a rise-time of 100 µs and duration of around 0.25 ms. ABR was used to evaluate the auditory function. The two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometer (MALDI-TOF-MS) were used to identified the differential protein expression.Compared with the normal group, ABR thresholds were found significantly increased at 2, 4, 8, 16, 32 kHz (P<0.05) in the acute and recovery groups. There was a 40-60 dBSPL ABR threshold shift at all tested frequencies immediately after impulse noise exposure. There was a partial recovery of ABR thresholds at 7 day to 28 days after impulse noise exposure. In addition, it seemed that the thresholds were rather stable and no further ABR threshold recovery was observed from 14 day to 28 days after the impulse noise exposure. Using differential proteomic techniques, 36 spots containing 27 proteins were revealed and identified in auditory cortex. Those proteins are related to cytoskeleton, neurotransmission, energy supply, mitochondrial function and synaptic remolding.Impulse noise may influence the function of microtubule transport and cell metabolism, there after affect the neurotransmission of auditory neurons. The compensatory changes such as pre- and postsynaptic or such related functional changes may also happen in auditory cortex after the deafferentation treatment." @default.
- W2413618897 created "2016-06-24" @default.
- W2413618897 creator A5007583840 @default.
- W2413618897 creator A5038735445 @default.
- W2413618897 creator A5039468302 @default.
- W2413618897 creator A5068955422 @default.
- W2413618897 creator A5089343518 @default.
- W2413618897 date "2011-10-01" @default.
- W2413618897 modified "2023-10-18" @default.
- W2413618897 title "[Study on discrepant protein expression in rat auditory cortex under impulse noise exposure]." @default.
- W2413618897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22321423" @default.
- W2413618897 hasPublicationYear "2011" @default.
- W2413618897 type Work @default.
- W2413618897 sameAs 2413618897 @default.
- W2413618897 citedByCount "0" @default.
- W2413618897 crossrefType "journal-article" @default.
- W2413618897 hasAuthorship W2413618897A5007583840 @default.
- W2413618897 hasAuthorship W2413618897A5038735445 @default.
- W2413618897 hasAuthorship W2413618897A5039468302 @default.
- W2413618897 hasAuthorship W2413618897A5068955422 @default.
- W2413618897 hasAuthorship W2413618897A5089343518 @default.
- W2413618897 hasConcept C115961682 @default.
- W2413618897 hasConcept C120665830 @default.
- W2413618897 hasConcept C121332964 @default.
- W2413618897 hasConcept C126322002 @default.
- W2413618897 hasConcept C127372701 @default.
- W2413618897 hasConcept C154945302 @default.
- W2413618897 hasConcept C160633673 @default.
- W2413618897 hasConcept C2780297895 @default.
- W2413618897 hasConcept C41008148 @default.
- W2413618897 hasConcept C548259974 @default.
- W2413618897 hasConcept C62520636 @default.
- W2413618897 hasConcept C70836080 @default.
- W2413618897 hasConcept C71924100 @default.
- W2413618897 hasConcept C99498987 @default.
- W2413618897 hasConceptScore W2413618897C115961682 @default.
- W2413618897 hasConceptScore W2413618897C120665830 @default.
- W2413618897 hasConceptScore W2413618897C121332964 @default.
- W2413618897 hasConceptScore W2413618897C126322002 @default.
- W2413618897 hasConceptScore W2413618897C127372701 @default.
- W2413618897 hasConceptScore W2413618897C154945302 @default.
- W2413618897 hasConceptScore W2413618897C160633673 @default.
- W2413618897 hasConceptScore W2413618897C2780297895 @default.
- W2413618897 hasConceptScore W2413618897C41008148 @default.
- W2413618897 hasConceptScore W2413618897C548259974 @default.
- W2413618897 hasConceptScore W2413618897C62520636 @default.
- W2413618897 hasConceptScore W2413618897C70836080 @default.
- W2413618897 hasConceptScore W2413618897C71924100 @default.
- W2413618897 hasConceptScore W2413618897C99498987 @default.
- W2413618897 hasIssue "10" @default.
- W2413618897 hasLocation W24136188971 @default.
- W2413618897 hasOpenAccess W2413618897 @default.
- W2413618897 hasPrimaryLocation W24136188971 @default.
- W2413618897 hasRelatedWork W1497756365 @default.
- W2413618897 hasRelatedWork W1978784106 @default.
- W2413618897 hasRelatedWork W2053816499 @default.
- W2413618897 hasRelatedWork W2354855219 @default.
- W2413618897 hasRelatedWork W2358972739 @default.
- W2413618897 hasRelatedWork W2362416688 @default.
- W2413618897 hasRelatedWork W2409898061 @default.
- W2413618897 hasRelatedWork W2410590819 @default.
- W2413618897 hasRelatedWork W2760039379 @default.
- W2413618897 hasRelatedWork W53107696 @default.
- W2413618897 hasVolume "46" @default.
- W2413618897 isParatext "false" @default.
- W2413618897 isRetracted "false" @default.
- W2413618897 magId "2413618897" @default.
- W2413618897 workType "article" @default.