Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413743514> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2413743514 endingPage "70" @default.
- W2413743514 startingPage "66" @default.
- W2413743514 abstract "Primary biliary cirrhosis is a potentially lethal hepatobiliary disorder in which 90% of the patients are women. Histologically, the disease is characterized by a progressive destruction of intrahepatic bile ducts by autoreactive T lymphocytes. Although the underlying etiology remains unknown, potential hypotheses must take into account; a) the predilection of the disease for women of childbearing age, b) the frequent coexistence of bone and intestinal involvement, and c) the high prevalence of autoantibodies directed towards intracellular enzymes. With these considerations in mind, we hypothesized that exposure to P-ALP (placental alkaline phosphatase) during pregnancy results in autoreactivity directed towards all human tissues harboring the ALP enzyme (liver, bone and intestine) in genetically predisposed individuals.To test this hypothesis, we stimulated peripheral blood mononuclear cells of primary biliary cirrhosis patients (n = 17) cholestatic liver disease controls (n = 6) and healthy controls (n = 14) with P-ALP, polyclonal activators (phytohemagglutinin [PHA], anti-CD3) and recall antigens (tetanus toxoid, streptokinase). We then determined their proliferative and cytokine responses by 3H-thymidine incorporation and ELISA assays for Il-10, IL-6, tumor necrosis factor-alpha and interferon-gamma, respectively.The results of the study revealed that the proliferative response to P-ALP was similar in peripheral blood mononuclear cells from primary biliary cirrhosis patients, cholestatic and healthy controls. Although the proliferative responses to PHA (P < 0.001) and anti-CD3 (P < 0.001) were decreased in peripheral blood mononuclear cells from primary biliary cirrhosis patients when compared to both control groups, responses to the recall antigens; tetanus toxoid and streptokinase were similar in the three groups. Cytokine production following exposure to P-ALP, polyclonal activators or recall antigens in peripheral blood mononuclear cells from primary biliary cirrhosis patients was similar to that of cholestatic and healthy controls.The results of the above experiments suggest that P-ALP is unlikely to be the target autoantigen in primary biliary cirrhosis. The results also support the findings of other investigators that primary biliary cirrhosis patients have suppressed proliferative responses to polyclonal stimulation." @default.
- W2413743514 created "2016-06-24" @default.
- W2413743514 creator A5035654219 @default.
- W2413743514 creator A5067807017 @default.
- W2413743514 creator A5076144286 @default.
- W2413743514 date "2001-03-28" @default.
- W2413743514 modified "2023-09-27" @default.
- W2413743514 title "The immune response to alkaline phosphatase and other immunogens in patients with primary biliary cirrhosis." @default.
- W2413743514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11269001" @default.
- W2413743514 hasPublicationYear "2001" @default.
- W2413743514 type Work @default.
- W2413743514 sameAs 2413743514 @default.
- W2413743514 citedByCount "0" @default.
- W2413743514 crossrefType "journal-article" @default.
- W2413743514 hasAuthorship W2413743514A5035654219 @default.
- W2413743514 hasAuthorship W2413743514A5067807017 @default.
- W2413743514 hasAuthorship W2413743514A5076144286 @default.
- W2413743514 hasConcept C126322002 @default.
- W2413743514 hasConcept C137061746 @default.
- W2413743514 hasConcept C147483822 @default.
- W2413743514 hasConcept C160160445 @default.
- W2413743514 hasConcept C181199279 @default.
- W2413743514 hasConcept C202751555 @default.
- W2413743514 hasConcept C203014093 @default.
- W2413743514 hasConcept C2777351567 @default.
- W2413743514 hasConcept C2780366471 @default.
- W2413743514 hasConcept C2780801004 @default.
- W2413743514 hasConcept C55493867 @default.
- W2413743514 hasConcept C71924100 @default.
- W2413743514 hasConcept C86803240 @default.
- W2413743514 hasConcept C8891405 @default.
- W2413743514 hasConceptScore W2413743514C126322002 @default.
- W2413743514 hasConceptScore W2413743514C137061746 @default.
- W2413743514 hasConceptScore W2413743514C147483822 @default.
- W2413743514 hasConceptScore W2413743514C160160445 @default.
- W2413743514 hasConceptScore W2413743514C181199279 @default.
- W2413743514 hasConceptScore W2413743514C202751555 @default.
- W2413743514 hasConceptScore W2413743514C203014093 @default.
- W2413743514 hasConceptScore W2413743514C2777351567 @default.
- W2413743514 hasConceptScore W2413743514C2780366471 @default.
- W2413743514 hasConceptScore W2413743514C2780801004 @default.
- W2413743514 hasConceptScore W2413743514C55493867 @default.
- W2413743514 hasConceptScore W2413743514C71924100 @default.
- W2413743514 hasConceptScore W2413743514C86803240 @default.
- W2413743514 hasConceptScore W2413743514C8891405 @default.
- W2413743514 hasIssue "37" @default.
- W2413743514 hasLocation W24137435141 @default.
- W2413743514 hasOpenAccess W2413743514 @default.
- W2413743514 hasPrimaryLocation W24137435141 @default.
- W2413743514 hasRelatedWork W1967254489 @default.
- W2413743514 hasRelatedWork W2012012488 @default.
- W2413743514 hasRelatedWork W2028497726 @default.
- W2413743514 hasRelatedWork W2069039175 @default.
- W2413743514 hasRelatedWork W2077024982 @default.
- W2413743514 hasRelatedWork W2080019390 @default.
- W2413743514 hasRelatedWork W2139188664 @default.
- W2413743514 hasRelatedWork W2381196212 @default.
- W2413743514 hasRelatedWork W2399441587 @default.
- W2413743514 hasRelatedWork W2413743514 @default.
- W2413743514 hasVolume "48" @default.
- W2413743514 isParatext "false" @default.
- W2413743514 isRetracted "false" @default.
- W2413743514 magId "2413743514" @default.
- W2413743514 workType "article" @default.