FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413794015> ?p ?o ?g. }

• W2413794015 endingPage "20" @default.
• W2413794015 startingPage "7" @default.
• W2413794015 abstract "Fifty years ago the dogma prevailed that alcohol was not toxic to the liver and that alcoholic liver disease was exclusively a consequence of nutritional deficiencies. We showed, however, that liver pathology developed even in the absence of malnutrition. This toxicity of alcohol was linked to its metabolism via alcohol dehydrogenase which converts nicotinamide adenine dinucleotide (NAD) to nicotinamide adenine dinucleotide-reduced form (NADH) which contributes to hyperuricemia, hypoglycemia and hepatic steatosis by inhibiting lipid oxidation and promoting lipogenesis. We also discovered a new pathway of ethanol metabolism, the microsomal ethanol oxidizing system (MEOS). The activity of its main enzyme, cytochrome P4502E1 (CYP2E1), and its gene are increased by chronic consumption, resulting in metabolic tolerance to ethanol. CYP2E1 also detoxifies many drugs but occasionally toxic and even carcinogenic metabolites are produced. This activity is also associated with the generation of free radicals with resulting lipid peroxidation and membrane damage as well as depletion of mitochondrial reduced glutathione (GSH) and its ultimate precursor, namely methionine activated to S-adenosylmethionine (SAMe). Its repletion restores liver functions. Administration of polyenylphosphatidylcholine (PPC), a mixture of unsaturated phosphatidylcholines (PC) extracted from soybeans, restores the structure of the membranes and the function of the corresponding enzymes. Ethanol impairs the conversion of beta-carotene to vitamin A and depletes hepatic vitamin A and, when it is given together with vitamin A or beta-carotene, hepatotoxicity is potentiated. Our present therapeutic approach is to reduce excess alcohol consumption by the Brief Intervention technique found to be very successful. We correct hepatic SAMe depletion and supplementation with PPC has some favorable effects on parameters of liver damage which continue to be evaluated. Similarly dilinoleoylphosphatidylcholine (DLPC), PPC's main component, also partially opposes the increase in CYP2E1 by ethanol. Hence, therapy with SAMe +DLPC is now being considered." @default.
• W2413794015 created "2016-06-24" @default.
• W2413794015 creator A5031788429 @default.
• W2413794015 date "2005-01-01" @default.
• W2413794015 modified "2023-09-23" @default.
• W2413794015 title "Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years." @default.
• W2413794015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16363067" @default.
• W2413794015 hasPublicationYear "2005" @default.
• W2413794015 type Work @default.
• W2413794015 sameAs 2413794015 @default.
• W2413794015 citedByCount "14" @default.
• W2413794015 countsByYear W24137940152012 @default.
• W2413794015 countsByYear W24137940152014 @default.
• W2413794015 countsByYear W24137940152015 @default.
• W2413794015 countsByYear W24137940152017 @default.
• W2413794015 countsByYear W24137940152018 @default.
• W2413794015 countsByYear W24137940152019 @default.
• W2413794015 countsByYear W24137940152020 @default.
• W2413794015 countsByYear W24137940152023 @default.
• W2413794015 crossrefType "journal-article" @default.
• W2413794015 hasAuthorship W2413794015A5031788429 @default.
• W2413794015 hasConcept C126322002 @default.
• W2413794015 hasConcept C134018914 @default.
• W2413794015 hasConcept C140027455 @default.
• W2413794015 hasConcept C141359234 @default.
• W2413794015 hasConcept C181199279 @default.
• W2413794015 hasConcept C185592680 @default.
• W2413794015 hasConcept C2776901170 @default.
• W2413794015 hasConcept C2776940978 @default.
• W2413794015 hasConcept C2777214474 @default.
• W2413794015 hasConcept C2777344606 @default.
• W2413794015 hasConcept C2777575235 @default.
• W2413794015 hasConcept C2777989768 @default.
• W2413794015 hasConcept C2778004101 @default.
• W2413794015 hasConcept C2778772119 @default.
• W2413794015 hasConcept C2779134260 @default.
• W2413794015 hasConcept C2780829032 @default.
• W2413794015 hasConcept C30153976 @default.
• W2413794015 hasConcept C38485361 @default.
• W2413794015 hasConcept C526171541 @default.
• W2413794015 hasConcept C538909803 @default.
• W2413794015 hasConcept C55493867 @default.
• W2413794015 hasConcept C62231903 @default.
• W2413794015 hasConcept C71924100 @default.
• W2413794015 hasConcept C75520062 @default.
• W2413794015 hasConcept C86803240 @default.
• W2413794015 hasConceptScore W2413794015C126322002 @default.
• W2413794015 hasConceptScore W2413794015C134018914 @default.
• W2413794015 hasConceptScore W2413794015C140027455 @default.
• W2413794015 hasConceptScore W2413794015C141359234 @default.
• W2413794015 hasConceptScore W2413794015C181199279 @default.
• W2413794015 hasConceptScore W2413794015C185592680 @default.
• W2413794015 hasConceptScore W2413794015C2776901170 @default.
• W2413794015 hasConceptScore W2413794015C2776940978 @default.
• W2413794015 hasConceptScore W2413794015C2777214474 @default.
• W2413794015 hasConceptScore W2413794015C2777344606 @default.
• W2413794015 hasConceptScore W2413794015C2777575235 @default.
• W2413794015 hasConceptScore W2413794015C2777989768 @default.
• W2413794015 hasConceptScore W2413794015C2778004101 @default.
• W2413794015 hasConceptScore W2413794015C2778772119 @default.
• W2413794015 hasConceptScore W2413794015C2779134260 @default.
• W2413794015 hasConceptScore W2413794015C2780829032 @default.
• W2413794015 hasConceptScore W2413794015C30153976 @default.
• W2413794015 hasConceptScore W2413794015C38485361 @default.
• W2413794015 hasConceptScore W2413794015C526171541 @default.
• W2413794015 hasConceptScore W2413794015C538909803 @default.
• W2413794015 hasConceptScore W2413794015C55493867 @default.
• W2413794015 hasConceptScore W2413794015C62231903 @default.
• W2413794015 hasConceptScore W2413794015C71924100 @default.
• W2413794015 hasConceptScore W2413794015C75520062 @default.
• W2413794015 hasConceptScore W2413794015C86803240 @default.
• W2413794015 hasLocation W24137940151 @default.
• W2413794015 hasOpenAccess W2413794015 @default.
• W2413794015 hasPrimaryLocation W24137940151 @default.
• W2413794015 hasRelatedWork W1491137382 @default.
• W2413794015 hasRelatedWork W1984030430 @default.
• W2413794015 hasRelatedWork W2005797238 @default.
• W2413794015 hasRelatedWork W2028467072 @default.
• W2413794015 hasRelatedWork W203531690 @default.
• W2413794015 hasRelatedWork W2035559527 @default.
• W2413794015 hasRelatedWork W2060432840 @default.
• W2413794015 hasRelatedWork W2088972724 @default.
• W2413794015 hasRelatedWork W2111757867 @default.
• W2413794015 hasRelatedWork W2113522316 @default.
• W2413794015 hasRelatedWork W2126958674 @default.
• W2413794015 hasRelatedWork W2176154147 @default.
• W2413794015 hasRelatedWork W2312553369 @default.
• W2413794015 hasRelatedWork W2400582136 @default.
• W2413794015 hasRelatedWork W2402712755 @default.
• W2413794015 hasRelatedWork W2405821923 @default.
• W2413794015 hasRelatedWork W2411756752 @default.
• W2413794015 hasRelatedWork W2418657835 @default.
• W2413794015 hasRelatedWork W2431112311 @default.
• W2413794015 hasRelatedWork W53554089 @default.
• W2413794015 hasVolume "50" @default.
• W2413794015 isParatext "false" @default.
• W2413794015 isRetracted "false" @default.
• W2413794015 magId "2413794015" @default.

• next