FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413804313> ?p ?o ?g. }

• W2413804313 endingPage "63" @default.
• W2413804313 startingPage "59" @default.
• W2413804313 abstract "The most important known risk factor for ovarian cancer is the BRCA1-2 mutation, which is clinically often manifested through a positive family history of cancer of the breast and/or ovary. Whether other risk factors and prognostic factors in women with a positive family history of cancer of the breast and/or ovary and/or with BRCA1-2 mutation are important remains to be elucidated. Recent studies have shown that in the double primary breast and ovarian cancer (DPBOC), BRCA1-2 mutation is present in at least 86% of cases. Therefore, the group of patients with DPBOC, especially with epithelial ovarian cancer and breast cancer, is the most suitable for such an analysis. The aim of this study was to verify the hypothesis that, in this group, some other risk factors, in addition to a specific family history of cancer, as well as unfavourable pathomorphological prognostic factors, are more expressed than in a control group of patients with sporadic epithelial ovarian cancer only.We compared the study group of 31 patients with DPBOC (epithelial ovarian cancer) to a control group of 62 patients with a single, sporadic epithelial ovarian cancer and negative specific family history. The data were obtained from the Cancer Registry of Slovenia and from clinical records. For every patient, we filled-in a protocol and analysed the data, comparing other risk factors in addition to specific family history and prognostic, clinical, and pathomorphological factors. Statistical analysis was performed using descriptive statistics, chi-square test and t-test. Multivariate analysis was also planned, but the necessary conditions were not met.In the study group, we found a higher percentage of positive non-specific family histories than in the control group, but the difference was not statistically significant. No difference in procreative risk factors was observed between the groups. There was a higher percentage of borderline significance of women from the study group that developed ovarian cancer between 45 and 59 years of age. In the study group, ovarian cancer was significantly more often found at Stage I, although the groups did not differ in detection procedures. Also, we did not find any differences in the distribution of tumour grades or histologic tumour types.The results did not confirm our hypothesis, yet they indicated some differences between the groups regarding the risk factors for ovarian cancer. Regarding the prognostic factors, we even found a significantly higher percentage of Stage I epithelial ovarian cancer in the study group, with no difference in the mode of detection. Considering the results that are not typical of BRCA-related cancer (what double primary cancer of the ovary and breast is supposed to be) and previous reports, we find it more likely that the patients with BRCA1-2 mutations represent only a subgroup within the group of patients with double primary breast and ovarian cancer." @default.
• W2413804313 created "2016-06-24" @default.
• W2413804313 creator A5018774737 @default.
• W2413804313 creator A5027206974 @default.
• W2413804313 creator A5034689185 @default.
• W2413804313 date "2005-01-01" @default.
• W2413804313 modified "2023-09-27" @default.
• W2413804313 title "Risk factors and prognostic factors in patients with double primary cancer: epithelial ovarian cancer and breast cancer." @default.
• W2413804313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15755003" @default.
• W2413804313 hasPublicationYear "2005" @default.
• W2413804313 type Work @default.
• W2413804313 sameAs 2413804313 @default.
• W2413804313 citedByCount "5" @default.
• W2413804313 countsByYear W24138043132012 @default.
• W2413804313 countsByYear W24138043132023 @default.
• W2413804313 crossrefType "journal-article" @default.
• W2413804313 hasAuthorship W2413804313A5018774737 @default.
• W2413804313 hasAuthorship W2413804313A5027206974 @default.
• W2413804313 hasAuthorship W2413804313A5034689185 @default.
• W2413804313 hasConcept C121608353 @default.
• W2413804313 hasConcept C126322002 @default.
• W2413804313 hasConcept C143998085 @default.
• W2413804313 hasConcept C2780427987 @default.
• W2413804313 hasConcept C2781179581 @default.
• W2413804313 hasConcept C29456083 @default.
• W2413804313 hasConcept C530470458 @default.
• W2413804313 hasConcept C71924100 @default.
• W2413804313 hasConceptScore W2413804313C121608353 @default.
• W2413804313 hasConceptScore W2413804313C126322002 @default.
• W2413804313 hasConceptScore W2413804313C143998085 @default.
• W2413804313 hasConceptScore W2413804313C2780427987 @default.
• W2413804313 hasConceptScore W2413804313C2781179581 @default.
• W2413804313 hasConceptScore W2413804313C29456083 @default.
• W2413804313 hasConceptScore W2413804313C530470458 @default.
• W2413804313 hasConceptScore W2413804313C71924100 @default.
• W2413804313 hasIssue "1" @default.
• W2413804313 hasLocation W24138043131 @default.
• W2413804313 hasOpenAccess W2413804313 @default.
• W2413804313 hasPrimaryLocation W24138043131 @default.
• W2413804313 hasRelatedWork W1977506104 @default.
• W2413804313 hasRelatedWork W2023425329 @default.
• W2413804313 hasRelatedWork W2048554408 @default.
• W2413804313 hasRelatedWork W2082618958 @default.
• W2413804313 hasRelatedWork W2126725202 @default.
• W2413804313 hasRelatedWork W2415098735 @default.
• W2413804313 hasRelatedWork W2514059102 @default.
• W2413804313 hasRelatedWork W2586778810 @default.
• W2413804313 hasRelatedWork W3000291420 @default.
• W2413804313 hasRelatedWork W3176358214 @default.
• W2413804313 hasVolume "26" @default.
• W2413804313 isParatext "false" @default.
• W2413804313 isRetracted "false" @default.
• W2413804313 magId "2413804313" @default.
• W2413804313 workType "article" @default.