FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413860166> ?p ?o ?g. }

• W2413860166 endingPage "E172" @default.
• W2413860166 startingPage "E163" @default.
• W2413860166 abstract "The net release of glucose from the liver, or hepatic glucose production (HGP), and apparent gluconeogenesis (GNG) are reduced by exogenous glucose. We investigated the changes in metabolic fluxes responsible. Flux through the hepatic GNG pathway was quantified by mass isotopomer distribution analysis (MIDA) from [2-13C]glycerol. Unidirectional flux across hepatic glucose-6-phosphatase (G-6-Pase), or total hepatic glucose output (THGO), and hepatic glucose cycling (HGC) were also measured by using glucuronate (GlcUA) to correct for glucose 6-phosphate (G-6-P) labeling. Infusion of glucose (15-30 mg.kg-1.min-1 iv) to 24 h-fasted rats caused two important metabolic alterations. First was a significant increase in hepatic glucose uptake and HGC: > 60% of THGO was from HGC. Second, although flux through hepatic G-6-P increased (from 15.7 to 17.7-22.7 mg.kg-1.min-1), the partitioning of G-6-P flux changed markedly [from 30-35% to 55-60% entering UDP-glucose (UDP-Glc), P < 0.01]. Total flux through the GNG pathway remained active during intravenous glucose, but increased partitioning into UDP-Glc lowered GNG flux plasma glucose by 50%. In summary, the suppression of HGP and GNG flux into glucose is not primarily due to reduced carbon flow through hepatic G-6-Pase or the hepatic GNG pathway. THGO persists, but hepatic G-6-P is derived increasingly from plasma glucose, and flow through GNG persists, but the partitioning coefficient of G-6-P into UDP-Glc doubles. These adjustments permit net HGP to fall despite increased total production of hepatic G-6-P during administration of glucose." @default.
• W2413860166 created "2016-06-24" @default.
• W2413860166 creator A5014347604 @default.
• W2413860166 creator A5014393890 @default.
• W2413860166 creator A5026672801 @default.
• W2413860166 creator A5047114493 @default.
• W2413860166 creator A5051436469 @default.
• W2413860166 creator A5076893457 @default.
• W2413860166 date "1997-01-01" @default.
• W2413860166 modified "2023-10-06" @default.
• W2413860166 title "Altered fluxes responsible for reduced hepatic glucose production and gluconeogenesis by exogenous glucose in rats" @default.
• W2413860166 cites W1526998224 @default.
• W2413860166 cites W1606942984 @default.
• W2413860166 cites W1969012866 @default.
• W2413860166 cites W1981936195 @default.
• W2413860166 cites W2017776273 @default.
• W2413860166 cites W2027667229 @default.
• W2413860166 cites W2065161514 @default.
• W2413860166 cites W2076433657 @default.
• W2413860166 cites W2086130857 @default.
• W2413860166 cites W2092745778 @default.
• W2413860166 cites W2111900101 @default.
• W2413860166 cites W2113048216 @default.
• W2413860166 cites W2124232607 @default.
• W2413860166 cites W2125140365 @default.
• W2413860166 cites W2134212766 @default.
• W2413860166 cites W2142764009 @default.
• W2413860166 cites W2156093747 @default.
• W2413860166 cites W2171169214 @default.
• W2413860166 cites W21786988 @default.
• W2413860166 cites W2525793442 @default.
• W2413860166 cites W2977920816 @default.
• W2413860166 cites W2022168568 @default.
• W2413860166 doi "https://doi.org/10.1152/ajpendo.1997.272.1.e163" @default.
• W2413860166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9038866" @default.
• W2413860166 hasPublicationYear "1997" @default.
• W2413860166 type Work @default.
• W2413860166 sameAs 2413860166 @default.
• W2413860166 citedByCount "24" @default.
• W2413860166 countsByYear W24138601662016 @default.
• W2413860166 countsByYear W24138601662017 @default.
• W2413860166 countsByYear W24138601662018 @default.
• W2413860166 countsByYear W24138601662022 @default.
• W2413860166 countsByYear W24138601662023 @default.
• W2413860166 crossrefType "journal-article" @default.
• W2413860166 hasAuthorship W2413860166A5014347604 @default.
• W2413860166 hasAuthorship W2413860166A5014393890 @default.
• W2413860166 hasAuthorship W2413860166A5026672801 @default.
• W2413860166 hasAuthorship W2413860166A5047114493 @default.
• W2413860166 hasAuthorship W2413860166A5051436469 @default.
• W2413860166 hasAuthorship W2413860166A5076893457 @default.
• W2413860166 hasConcept C126322002 @default.
• W2413860166 hasConcept C134018914 @default.
• W2413860166 hasConcept C160941953 @default.
• W2413860166 hasConcept C178790620 @default.
• W2413860166 hasConcept C181199279 @default.
• W2413860166 hasConcept C185592680 @default.
• W2413860166 hasConcept C20904676 @default.
• W2413860166 hasConcept C2777790778 @default.
• W2413860166 hasConcept C2779202576 @default.
• W2413860166 hasConcept C55493867 @default.
• W2413860166 hasConcept C62231903 @default.
• W2413860166 hasConcept C68709404 @default.
• W2413860166 hasConcept C71924100 @default.
• W2413860166 hasConcept C86803240 @default.
• W2413860166 hasConceptScore W2413860166C126322002 @default.
• W2413860166 hasConceptScore W2413860166C134018914 @default.
• W2413860166 hasConceptScore W2413860166C160941953 @default.
• W2413860166 hasConceptScore W2413860166C178790620 @default.
• W2413860166 hasConceptScore W2413860166C181199279 @default.
• W2413860166 hasConceptScore W2413860166C185592680 @default.
• W2413860166 hasConceptScore W2413860166C20904676 @default.
• W2413860166 hasConceptScore W2413860166C2777790778 @default.
• W2413860166 hasConceptScore W2413860166C2779202576 @default.
• W2413860166 hasConceptScore W2413860166C55493867 @default.
• W2413860166 hasConceptScore W2413860166C62231903 @default.
• W2413860166 hasConceptScore W2413860166C68709404 @default.
• W2413860166 hasConceptScore W2413860166C71924100 @default.
• W2413860166 hasConceptScore W2413860166C86803240 @default.
• W2413860166 hasIssue "1" @default.
• W2413860166 hasLocation W24138601661 @default.
• W2413860166 hasLocation W24138601662 @default.
• W2413860166 hasOpenAccess W2413860166 @default.
• W2413860166 hasPrimaryLocation W24138601661 @default.
• W2413860166 hasRelatedWork W2006574043 @default.
• W2413860166 hasRelatedWork W2009642048 @default.
• W2413860166 hasRelatedWork W2064940611 @default.
• W2413860166 hasRelatedWork W2091844621 @default.
• W2413860166 hasRelatedWork W2156187506 @default.
• W2413860166 hasRelatedWork W2413860166 @default.
• W2413860166 hasRelatedWork W2464596983 @default.
• W2413860166 hasRelatedWork W2473387876 @default.
• W2413860166 hasRelatedWork W2963017100 @default.
• W2413860166 hasRelatedWork W4246710695 @default.
• W2413860166 hasVolume "272" @default.
• W2413860166 isParatext "false" @default.
• W2413860166 isRetracted "false" @default.
• W2413860166 magId "2413860166" @default.

• next