Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413883940> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2413883940 endingPage "F352" @default.
- W2413883940 startingPage "F346" @default.
- W2413883940 abstract "Maintenance of cell calcium homeostasis and transepithelial transport of this cation require its extrusion from the cell against a steep electrochemical gradient. Because it has been proposed that a membrane Ca-ATPase activated by micromolar concentrations of Ca2+ prevailing in the cell participates in these processes, we attempted in this study to determine whether such an enzyme is present in the rabbit nephron. A magnesium-dependent ATPase, maximally activated by Ca2+ (Ca-Mg-ATPase) concentrations between 1.1 and 2.3 microM (apparent Km = 0.3-0.4 microM), was found in all segments of the nephron. Ca-Mg-ATPase (pmol.mm-1.h-1) was highest in the distal convoluted tubule (243) and cortical collecting tubule (208), intermediate in the proximal convoluted tubule (140) and medullary thick ascending limb of Henle's loop (135), and lower in the pars recta (97), cortical thick ascending limb (50), and medullary collecting tubule (51). The enzyme was insensitive to ouabain and vanadate, but was inhibited by ruthenium red in a dose-dependent manner (Ki congruent to 2.10(-6) M). Sodium azide, an inhibitor of mitochondrial ATPase, did not affect Ca-Mg-ATPase, suggesting that the enzyme was located in the plasma membrane. The Ca-Mg-ATPase activity measured in most segments of the rabbit nephron in this study appears sufficient to account in theory for the active component of the unidirectional (lumen-to-bath) calcium flux found in the corresponding region of the nephron with in vitro single tubule microperfusion techniques." @default.
- W2413883940 created "2016-06-24" @default.
- W2413883940 creator A5051436796 @default.
- W2413883940 creator A5090407013 @default.
- W2413883940 date "1982-04-01" @default.
- W2413883940 modified "2023-09-26" @default.
- W2413883940 title "High-affinity Ca-Mg-ATPase along the rabbit nephron" @default.
- W2413883940 doi "https://doi.org/10.1152/ajprenal.1982.242.4.f346" @default.
- W2413883940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6175229" @default.
- W2413883940 hasPublicationYear "1982" @default.
- W2413883940 type Work @default.
- W2413883940 sameAs 2413883940 @default.
- W2413883940 citedByCount "39" @default.
- W2413883940 countsByYear W24138839402012 @default.
- W2413883940 countsByYear W24138839402016 @default.
- W2413883940 countsByYear W24138839402017 @default.
- W2413883940 crossrefType "journal-article" @default.
- W2413883940 hasAuthorship W2413883940A5051436796 @default.
- W2413883940 hasAuthorship W2413883940A5090407013 @default.
- W2413883940 hasConcept C12554922 @default.
- W2413883940 hasConcept C126322002 @default.
- W2413883940 hasConcept C134018914 @default.
- W2413883940 hasConcept C178790620 @default.
- W2413883940 hasConcept C181199279 @default.
- W2413883940 hasConcept C185592680 @default.
- W2413883940 hasConcept C23265538 @default.
- W2413883940 hasConcept C2776777027 @default.
- W2413883940 hasConcept C2776844834 @default.
- W2413883940 hasConcept C2779010597 @default.
- W2413883940 hasConcept C2779133857 @default.
- W2413883940 hasConcept C2780091579 @default.
- W2413883940 hasConcept C2780498532 @default.
- W2413883940 hasConcept C2781116636 @default.
- W2413883940 hasConcept C2781231759 @default.
- W2413883940 hasConcept C537181965 @default.
- W2413883940 hasConcept C55493867 @default.
- W2413883940 hasConcept C71924100 @default.
- W2413883940 hasConcept C86803240 @default.
- W2413883940 hasConceptScore W2413883940C12554922 @default.
- W2413883940 hasConceptScore W2413883940C126322002 @default.
- W2413883940 hasConceptScore W2413883940C134018914 @default.
- W2413883940 hasConceptScore W2413883940C178790620 @default.
- W2413883940 hasConceptScore W2413883940C181199279 @default.
- W2413883940 hasConceptScore W2413883940C185592680 @default.
- W2413883940 hasConceptScore W2413883940C23265538 @default.
- W2413883940 hasConceptScore W2413883940C2776777027 @default.
- W2413883940 hasConceptScore W2413883940C2776844834 @default.
- W2413883940 hasConceptScore W2413883940C2779010597 @default.
- W2413883940 hasConceptScore W2413883940C2779133857 @default.
- W2413883940 hasConceptScore W2413883940C2780091579 @default.
- W2413883940 hasConceptScore W2413883940C2780498532 @default.
- W2413883940 hasConceptScore W2413883940C2781116636 @default.
- W2413883940 hasConceptScore W2413883940C2781231759 @default.
- W2413883940 hasConceptScore W2413883940C537181965 @default.
- W2413883940 hasConceptScore W2413883940C55493867 @default.
- W2413883940 hasConceptScore W2413883940C71924100 @default.
- W2413883940 hasConceptScore W2413883940C86803240 @default.
- W2413883940 hasIssue "4" @default.
- W2413883940 hasLocation W24138839401 @default.
- W2413883940 hasLocation W24138839402 @default.
- W2413883940 hasOpenAccess W2413883940 @default.
- W2413883940 hasPrimaryLocation W24138839401 @default.
- W2413883940 hasRelatedWork W1752750000 @default.
- W2413883940 hasRelatedWork W1963639085 @default.
- W2413883940 hasRelatedWork W1965534679 @default.
- W2413883940 hasRelatedWork W1970175115 @default.
- W2413883940 hasRelatedWork W2056684371 @default.
- W2413883940 hasRelatedWork W2058430087 @default.
- W2413883940 hasRelatedWork W2061932778 @default.
- W2413883940 hasRelatedWork W2393901654 @default.
- W2413883940 hasRelatedWork W2413883940 @default.
- W2413883940 hasRelatedWork W2744702368 @default.
- W2413883940 hasVolume "242" @default.
- W2413883940 isParatext "false" @default.
- W2413883940 isRetracted "false" @default.
- W2413883940 magId "2413883940" @default.
- W2413883940 workType "article" @default.