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- W2413888787 abstract "Formation of a developmentally arrested dis- persal stage called the dauer larva is enhanced by a Caeno- rhabditis-specific pheromone and is inhibited by increasing amounts of food. Pheromone-induced dauer larva formation of three tested wild-type strains is temperature-dependent, so that an increased percentage of the population forms dauer larvae at 25?C compared to lower temperatures. Dauer-defec- tive mutants fail to respond to added pheromone, and some behavioral mutants affected in thermotaxis or egg-laying also exhibit abnormal responses. Temperature-sensitive (ts) dauer- constitutive mutants form dauer larvae at a restrictive tem- perature regardless of environmental stimuli. At the permis- sive temperature (17.5?C), alleles of six out of seven dauer- constitutive genes tested overrespond to the dauer-inducing pheromone. All known mutations in daf-4 (eight alleles) and daf-7 (five alleles) produce a ts dauer-constitutive phenotype. One daf-4 and one daf-7 allele are suppressed by the amber nonsense suppressor, sup-7(st5). At least these two dauer-con- stitutive mutations are likely to cause production' of nonfunc- tional rather than ts gene products. These mutations appear to indirectly result in a ts phenotype by enhancing the expression of a wild-type ts developmental process." @default.
- W2413888787 created "2016-06-24" @default.
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- W2413888787 date "2016-01-01" @default.
- W2413888787 modified "2023-09-24" @default.
- W2413888787 title "A pheromone-induced development elegans: Temperature-sensitive mul temperature-dependent process (nematode/dauer larva/informational suppression)" @default.
- W2413888787 hasPublicationYear "2016" @default.
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