FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413889436> ?p ?o ?g. }

• W2413889436 endingPage "461" @default.
• W2413889436 startingPage "461" @default.
• W2413889436 abstract "Despite pathophysiological links between endothelin-1 and pulmonary vascular remodeling, to our knowledge, the association between plasma endothelin-1 levels and pulmonary hypertension has not been studied in the general population. Also, whether endothelin-1 can predict future heart failure and mortality, outcomes that are associated with pulmonary hypertension, in a population cohort is unclear.To determine whether elevated plasma endothelin-1 levels are associated with pulmonary hypertension, mortality, and heart failure.Data from the Jackson Heart Study, a longitudinal, prospective observational cohort study of heart disease in African American individuals from Jackson, Mississippi, were analyzed. The community population sample was limited to participants with detectable tricuspid regurgitation on echocardiography. The study participants included self-identified African American individuals with plasma endothelin-1 levels and tricuspid regurgitation on echocardiogram (n = 3223) at the time of first examination (2000-2004). The analysis of the data began on April 14, 2014, and was completed on February 23, 2016.Log-transformed plasma endothelin-1 level.Cross-sectional analysis: presence of pulmonary hypertension (defined as an elevated pulmonary artery systolic pressure >40 mm Hg on echocardiogram). Longitudinal outcomes were all-cause mortality (median follow-up, 7.75 years) and heart failure admissions (median follow-up, 5.32 years).Of the 3223 participants enrolled in the study, 1051 were men (32.6%). Mean (SD) endothelin-1 levels were 1.36 (0.64) pg/mL; 217 of 3223 cohort members (6.7%) had pulmonary hypertension. After adjusting for potential confounders, log-transformed endothelin-1 levels were associated with increased odds of pulmonary hypertension (adjusted odds ratio per log increment in endothelin-1, 1.66; 95% CI, 1.16-2.37). Log-transformed endothelin-1 levels were associated with mortality (adjusted hazard ratio per log increment in endothelin-1, 1.69; 95% CI, 1.27-2.25; median follow-up, 7.75 years) and heart failure (adjusted hazard ratio per log increment in endothelin-1, 1.57, 95% CI, 1.05-2.37; median follow-up, 5.32 years) in the study cohort. Phenotyping by pulmonary hypertension and endothelin-1 level showed mortality decreasing in order from subgroup with pulmonary hypertension and high endothelin-1 (high endothelin-1: ≥1.7 pg/mL; upper quartile); pulmonary hypertension and low endothelin-1 <1.7 pg/mL; lower 3 quartiles); no pulmonary hypertension and high endothelin-1; and no pulmonary hypertension and low endothelin-1 (log-rank χ2 = 77.16; P < .01 ).Elevated plasma endothelin-1 levels, especially associated with an elevated pulmonary artery systolic pressure on echocardiogram, may identify an at-risk population that could be evaluated for targeted prevention and management strategies in future studies." @default.
• W2413889436 created "2016-06-24" @default.
• W2413889436 creator A5006335310 @default.
• W2413889436 creator A5065877953 @default.
• W2413889436 creator A5083996164 @default.
• W2413889436 date "2016-07-01" @default.
• W2413889436 modified "2023-10-16" @default.
• W2413889436 title "Association of Elevated Plasma Endothelin-1 Levels With Pulmonary Hypertension, Mortality, and Heart Failure in African American Individuals" @default.
• W2413889436 cites W141271274 @default.
• W2413889436 cites W1480259837 @default.
• W2413889436 cites W1813207029 @default.
• W2413889436 cites W1970297982 @default.
• W2413889436 cites W1972565751 @default.
• W2413889436 cites W1973380773 @default.
• W2413889436 cites W1979604318 @default.
• W2413889436 cites W1987022473 @default.
• W2413889436 cites W1992989380 @default.
• W2413889436 cites W2003399513 @default.
• W2413889436 cites W2004922395 @default.
• W2413889436 cites W2008516710 @default.
• W2413889436 cites W2011113398 @default.
• W2413889436 cites W2011358968 @default.
• W2413889436 cites W2022943665 @default.
• W2413889436 cites W2026881482 @default.
• W2413889436 cites W2028386133 @default.
• W2413889436 cites W2031911042 @default.
• W2413889436 cites W2038981426 @default.
• W2413889436 cites W2039767184 @default.
• W2413889436 cites W2041376120 @default.
• W2413889436 cites W2044675863 @default.
• W2413889436 cites W2045877680 @default.
• W2413889436 cites W2048443661 @default.
• W2413889436 cites W2048872450 @default.
• W2413889436 cites W2062608369 @default.
• W2413889436 cites W2074954887 @default.
• W2413889436 cites W2085960118 @default.
• W2413889436 cites W2086464091 @default.
• W2413889436 cites W2090412678 @default.
• W2413889436 cites W2093943199 @default.
• W2413889436 cites W2106602362 @default.
• W2413889436 cites W2117259028 @default.
• W2413889436 cites W2124374338 @default.
• W2413889436 cites W2129800911 @default.
• W2413889436 cites W2134422033 @default.
• W2413889436 cites W2138866811 @default.
• W2413889436 cites W2139749578 @default.
• W2413889436 cites W2145012675 @default.
• W2413889436 cites W2150149941 @default.
• W2413889436 cites W2156858470 @default.
• W2413889436 cites W2157891776 @default.
• W2413889436 cites W2158862125 @default.
• W2413889436 cites W2161469339 @default.
• W2413889436 cites W2162804111 @default.
• W2413889436 cites W2297865244 @default.
• W2413889436 cites W2331461651 @default.
• W2413889436 cites W2331798828 @default.
• W2413889436 cites W2333569659 @default.
• W2413889436 cites W2336346210 @default.
• W2413889436 cites W2343896499 @default.
• W2413889436 cites W2623867926 @default.
• W2413889436 doi "https://doi.org/10.1001/jamacardio.2016.0962" @default.
• W2413889436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27438323" @default.
• W2413889436 hasPublicationYear "2016" @default.
• W2413889436 type Work @default.
• W2413889436 sameAs 2413889436 @default.
• W2413889436 citedByCount "38" @default.
• W2413889436 countsByYear W24138894362017 @default.
• W2413889436 countsByYear W24138894362018 @default.
• W2413889436 countsByYear W24138894362019 @default.
• W2413889436 countsByYear W24138894362020 @default.
• W2413889436 countsByYear W24138894362021 @default.
• W2413889436 countsByYear W24138894362022 @default.
• W2413889436 countsByYear W24138894362023 @default.
• W2413889436 crossrefType "journal-article" @default.
• W2413889436 hasAuthorship W2413889436A5006335310 @default.
• W2413889436 hasAuthorship W2413889436A5065877953 @default.
• W2413889436 hasAuthorship W2413889436A5083996164 @default.
• W2413889436 hasBestOaLocation W24138894361 @default.
• W2413889436 hasConcept C126322002 @default.
• W2413889436 hasConcept C156957248 @default.
• W2413889436 hasConcept C164705383 @default.
• W2413889436 hasConcept C201903717 @default.
• W2413889436 hasConcept C2778198053 @default.
• W2413889436 hasConcept C2780930700 @default.
• W2413889436 hasConcept C2780940725 @default.
• W2413889436 hasConcept C2908647359 @default.
• W2413889436 hasConcept C71924100 @default.
• W2413889436 hasConcept C72563966 @default.
• W2413889436 hasConcept C99454951 @default.
• W2413889436 hasConceptScore W2413889436C126322002 @default.
• W2413889436 hasConceptScore W2413889436C156957248 @default.
• W2413889436 hasConceptScore W2413889436C164705383 @default.
• W2413889436 hasConceptScore W2413889436C201903717 @default.
• W2413889436 hasConceptScore W2413889436C2778198053 @default.
• W2413889436 hasConceptScore W2413889436C2780930700 @default.
• W2413889436 hasConceptScore W2413889436C2780940725 @default.
• W2413889436 hasConceptScore W2413889436C2908647359 @default.
• W2413889436 hasConceptScore W2413889436C71924100 @default.

• next