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• W2413889872 abstract "Norovirus (NoV)-specific serum antibodies bind to NoV-derived virus-like particles (VLPs) and block the binding of VLPs to the host cell attachment factors/receptors, histo-blood group antigens (HBGAs). Blocking antibodies in human sera have been associated with a protection from NoV infection and disease. Studies of experimental NoV VLP-based vaccines measure blocking antibodies in animal sera instead of a traditional virus neutralization assay. This chapter describes the methodology for analyzing blocking antibodies from NoV GII.4 VLP-immunized mouse sera. Protocol for obtaining mouse NoV GII.4-specific immune sera is described, followed by the detailed protocol for blocking assay using synthetic HBGAs." @default.
• W2413889872 created "2016-06-24" @default.
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• W2413889872 date "2016-01-01" @default.
• W2413889872 modified "2023-09-23" @default.
• W2413889872 title "Assessment of Functional Norovirus Antibody Responses by Blocking Assay in Mice" @default.
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• W2413889872 doi "https://doi.org/10.1007/978-1-4939-3387-7_13" @default.
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• W2413889872 hasPublicationYear "2016" @default.
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