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- W2413891960 abstract "The importance of the nucleus tractus solitarius (NTS), ventrolateral medullary pressor area (VLPA), ventrolateral medullary depressor area (VLDA), and intermediolateral column (IML) of the spinal cord in cardiovascular regulation is well established. The presence of acetylcholine esterase, choline acetyltransferase, and muscarinic receptors has been demonstrated in the various regions of the medulla and the spinal cord that are known to be involved in cardiovascular regulation This chapter discusses the role of muscarinic receptor subtypes in the cardiovascular responses elicited by the microinjection of cholinergic agonists in the intermediate portion of the NTS, the VLPA, and VLDA areas and the IML of the spinal cord. The microinjections of L-glutamate have been used to identify these areas. Bilateral microinjections (0.02–2 nmol/site) of a potent M2 muscarinic receptor agonist, cis-methyldioxolane, but not those of a relatively selective M1 receptor agonist, into the intermediate portion of the NTS and VLDA induce depressor and bradycardic responses. In the VLPA, these agonists elicit pressor and tachycardic effects, while in the IML at T1–T3 only increase in heart rate has been observed." @default.
- W2413891960 created "2016-06-24" @default.
- W2413891960 creator A5069292077 @default.
- W2413891960 date "1989-01-01" @default.
- W2413891960 modified "2023-09-25" @default.
- W2413891960 title "Chapter 12 Cholinergic mechanisms subserving cardiovascular function in the medulla and spinal cord" @default.
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- W2413891960 doi "https://doi.org/10.1016/s0079-6123(08)62007-5" @default.
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