Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413893135> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2413893135 endingPage "16" @default.
- W2413893135 startingPage "107" @default.
- W2413893135 abstract "Recovery from ischaemia in heart tissue can be accelerated by addition of precursors of ATP such as AMP to the coronary circulation. Endocytosis in capillary endothelia is also stimulated by AMP; therefore endocytosis may be important in the transport of AMP from the circulation into myocytes. Alternatively, the increase in endocytotic transport itself could be responsible for accelerated recovery, irrespective of the stimulating agent. The effects of sham, AMP, cytochalasin-D (an inhibitor of endocytosis), and cytochalasin-D + AMP infusates given prior to, during, and following a 15 min ischaemic episode, were examined. AMP accelerated biochemical and functional recovery after episodes of ischaemia and stimulated endocytosis in coronary capillaries. Cytochalasin-D strongly inhibited contractility before, during, and after ischaemia, and similarly depressed ATP and creatine phosphate levels. Cytochalasin-D also strongly inhibited endocytosis and caused swelling of the capillary endothelium. When cytochalasin-D and AMP were provided together, the beneficial effects of AMP were only partially inhibited by cytochalasin-D. In fact, AMP was able to reverse most of the effects of cytochalasin-D including the inhibition of endocytosis. This suggests accelerated recovery of ischaemic myocytes requires precursors of ATP such as AMP, and the stimulation of endocytosis may abet transport of these precursors, or may be a spurious phenomenon." @default.
- W2413893135 created "2016-06-24" @default.
- W2413893135 creator A5042241867 @default.
- W2413893135 creator A5085607319 @default.
- W2413893135 date "1987-01-01" @default.
- W2413893135 modified "2023-09-23" @default.
- W2413893135 title "Recovery of myocardial function after ischaemia: the effects of AMP and inhibition of endocytosis." @default.
- W2413893135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3595209" @default.
- W2413893135 hasPublicationYear "1987" @default.
- W2413893135 type Work @default.
- W2413893135 sameAs 2413893135 @default.
- W2413893135 citedByCount "1" @default.
- W2413893135 crossrefType "journal-article" @default.
- W2413893135 hasAuthorship W2413893135A5042241867 @default.
- W2413893135 hasAuthorship W2413893135A5085607319 @default.
- W2413893135 hasConcept C126322002 @default.
- W2413893135 hasConcept C134018914 @default.
- W2413893135 hasConcept C142669718 @default.
- W2413893135 hasConcept C1491633281 @default.
- W2413893135 hasConcept C185592680 @default.
- W2413893135 hasConcept C2775995422 @default.
- W2413893135 hasConcept C2776041460 @default.
- W2413893135 hasConcept C2779012151 @default.
- W2413893135 hasConcept C28005876 @default.
- W2413893135 hasConcept C55493867 @default.
- W2413893135 hasConcept C71924100 @default.
- W2413893135 hasConcept C86803240 @default.
- W2413893135 hasConcept C95444343 @default.
- W2413893135 hasConceptScore W2413893135C126322002 @default.
- W2413893135 hasConceptScore W2413893135C134018914 @default.
- W2413893135 hasConceptScore W2413893135C142669718 @default.
- W2413893135 hasConceptScore W2413893135C1491633281 @default.
- W2413893135 hasConceptScore W2413893135C185592680 @default.
- W2413893135 hasConceptScore W2413893135C2775995422 @default.
- W2413893135 hasConceptScore W2413893135C2776041460 @default.
- W2413893135 hasConceptScore W2413893135C2779012151 @default.
- W2413893135 hasConceptScore W2413893135C28005876 @default.
- W2413893135 hasConceptScore W2413893135C55493867 @default.
- W2413893135 hasConceptScore W2413893135C71924100 @default.
- W2413893135 hasConceptScore W2413893135C86803240 @default.
- W2413893135 hasConceptScore W2413893135C95444343 @default.
- W2413893135 hasIssue "201" @default.
- W2413893135 hasLocation W24138931351 @default.
- W2413893135 hasOpenAccess W2413893135 @default.
- W2413893135 hasPrimaryLocation W24138931351 @default.
- W2413893135 hasRelatedWork W1543768950 @default.
- W2413893135 hasRelatedWork W1991456835 @default.
- W2413893135 hasRelatedWork W2005758722 @default.
- W2413893135 hasRelatedWork W2038988865 @default.
- W2413893135 hasRelatedWork W2071042607 @default.
- W2413893135 hasRelatedWork W2098419854 @default.
- W2413893135 hasRelatedWork W2154625078 @default.
- W2413893135 hasRelatedWork W2296164108 @default.
- W2413893135 hasRelatedWork W2395951685 @default.
- W2413893135 hasRelatedWork W2413893135 @default.
- W2413893135 hasVolume "50" @default.
- W2413893135 isParatext "false" @default.
- W2413893135 isRetracted "false" @default.
- W2413893135 magId "2413893135" @default.
- W2413893135 workType "article" @default.