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• W2413921428 startingPage "165" @default.
• W2413921428 abstract "Murine preadipocyte cell lines represent a convenient and informative model system for determining whether the mechanisms underlying oncogene-induced neoplastic transformation and the suppression of terminal differentiation are related. Preadipocytes transformed by a variety of oncogenic proteins, such as the Simian virus 40 (SV40) large-tumor antigen (SVLT) or activated ras oncogene (1–6) and others, fail to differentiate into adipocytes. However, the transformation and differentiation-inhibition functions are separable. Genetic analysis of SVLT has shown that at least two functional domains block differentiation independently. These include the N-terminal domain that binds to the cellular protein encoded by the retinoblastoma gene (Rb) (see Note 1) and a C-terminal function. However, only one of these two, the Rb-binding domain, is involved in neoplastic transformation (1,3). That is, the C-terminal function blocks differentiation independently of Rb-binding and independently of transformation (3). In addition, it was also shown that at low doses activated ras prevents adipocytic differentiation without inducing a fully transformed phenotype (5,6). Thus, structure-function analysis or dose analysis in the adipocyte system has helped distinguish oncogene functions not detectable using standard transformation assays alone." @default.
• W2413921428 created "2016-06-24" @default.
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• W2413921428 date "2003-11-15" @default.
• W2413921428 modified "2023-10-16" @default.
• W2413921428 title "Methods to Assess Inhibition of Adipocyte Differentiation by SV40 Large T Antigen" @default.
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• W2413921428 doi "https://doi.org/10.1385/1-59259-117-5:165" @default.
• W2413921428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11217384" @default.
• W2413921428 hasPublicationYear "2003" @default.
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