Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413930958> ?p ?o ?g. }
- W2413930958 abstract "The calcinosis that is present in scleroderma may result from an active process involving dysregulated mesenchymal stem cell differentiation, leading to a bone-forming microenvironment. It can be one of the most debilitating presentations of systemic sclerosis being found incidentally on X-rays or seen as an obvious clinical presentation. Analysis of the calcinotic particles by various techniques has identified carbonated hydroxyapatite crystals to be present. Vascular hypoxia and chronic inflammation have been proposed as contributing to the formation of calcinosis. Recent studies looking into regulators of bone mineralization in scleroderma patients with and without calcinosis as well as genetic studies are underway. However, no exact underlying pathogenesis has been found till date, and so, at this moment in time, there is no effective treatment. There are promising results with biologic agents given the fact that inflammation plays a role, yet this field requires more research to establish an effective therapy." @default.
- W2413930958 created "2016-06-24" @default.
- W2413930958 creator A5008207719 @default.
- W2413930958 creator A5037941636 @default.
- W2413930958 creator A5088985859 @default.
- W2413930958 creator A5089245762 @default.
- W2413930958 date "2020-01-01" @default.
- W2413930958 modified "2023-09-27" @default.
- W2413930958 title "Calcinosis in Scleroderma" @default.
- W2413930958 cites W150810505 @default.
- W2413930958 cites W1576293171 @default.
- W2413930958 cites W1838977799 @default.
- W2413930958 cites W1901763906 @default.
- W2413930958 cites W1905058540 @default.
- W2413930958 cites W1964648133 @default.
- W2413930958 cites W1971943934 @default.
- W2413930958 cites W1972767938 @default.
- W2413930958 cites W1973653270 @default.
- W2413930958 cites W1979917224 @default.
- W2413930958 cites W1991398317 @default.
- W2413930958 cites W2001452538 @default.
- W2413930958 cites W2002457445 @default.
- W2413930958 cites W2004866136 @default.
- W2413930958 cites W2012598193 @default.
- W2413930958 cites W2015375716 @default.
- W2413930958 cites W2020409699 @default.
- W2413930958 cites W2022791036 @default.
- W2413930958 cites W2031223778 @default.
- W2413930958 cites W2033376340 @default.
- W2413930958 cites W2043221062 @default.
- W2413930958 cites W2043654971 @default.
- W2413930958 cites W2054074666 @default.
- W2413930958 cites W2055466013 @default.
- W2413930958 cites W2058628090 @default.
- W2413930958 cites W2068096045 @default.
- W2413930958 cites W2070660957 @default.
- W2413930958 cites W2070664758 @default.
- W2413930958 cites W2080164196 @default.
- W2413930958 cites W2089606359 @default.
- W2413930958 cites W2093626245 @default.
- W2413930958 cites W2096719164 @default.
- W2413930958 cites W2098147369 @default.
- W2413930958 cites W2113163626 @default.
- W2413930958 cites W2113307617 @default.
- W2413930958 cites W2119109165 @default.
- W2413930958 cites W2119501410 @default.
- W2413930958 cites W2130470818 @default.
- W2413930958 cites W2131795083 @default.
- W2413930958 cites W2134102591 @default.
- W2413930958 cites W2141080803 @default.
- W2413930958 cites W2143421375 @default.
- W2413930958 cites W2146695920 @default.
- W2413930958 cites W2147225264 @default.
- W2413930958 cites W2151592155 @default.
- W2413930958 cites W2155527455 @default.
- W2413930958 cites W2160547406 @default.
- W2413930958 cites W2169118388 @default.
- W2413930958 cites W2273437768 @default.
- W2413930958 cites W2323985818 @default.
- W2413930958 cites W2327520940 @default.
- W2413930958 cites W2344827848 @default.
- W2413930958 cites W2406267088 @default.
- W2413930958 cites W2413039232 @default.
- W2413930958 cites W2526717031 @default.
- W2413930958 cites W2565530239 @default.
- W2413930958 cites W2617058725 @default.
- W2413930958 cites W2739261345 @default.
- W2413930958 cites W2789288587 @default.
- W2413930958 cites W3023169528 @default.
- W2413930958 cites W58029223 @default.
- W2413930958 doi "https://doi.org/10.1007/978-3-030-46725-8_12" @default.
- W2413930958 hasPublicationYear "2020" @default.
- W2413930958 type Work @default.
- W2413930958 sameAs 2413930958 @default.
- W2413930958 citedByCount "0" @default.
- W2413930958 crossrefType "book-chapter" @default.
- W2413930958 hasAuthorship W2413930958A5008207719 @default.
- W2413930958 hasAuthorship W2413930958A5037941636 @default.
- W2413930958 hasAuthorship W2413930958A5088985859 @default.
- W2413930958 hasAuthorship W2413930958A5089245762 @default.
- W2413930958 hasConcept C126322002 @default.
- W2413930958 hasConcept C142724271 @default.
- W2413930958 hasConcept C16005928 @default.
- W2413930958 hasConcept C180032290 @default.
- W2413930958 hasConcept C198826908 @default.
- W2413930958 hasConcept C203014093 @default.
- W2413930958 hasConcept C2775981168 @default.
- W2413930958 hasConcept C2776914184 @default.
- W2413930958 hasConcept C2778534260 @default.
- W2413930958 hasConcept C2779967694 @default.
- W2413930958 hasConcept C2780309369 @default.
- W2413930958 hasConcept C2780942790 @default.
- W2413930958 hasConcept C3017916928 @default.
- W2413930958 hasConcept C71924100 @default.
- W2413930958 hasConceptScore W2413930958C126322002 @default.
- W2413930958 hasConceptScore W2413930958C142724271 @default.
- W2413930958 hasConceptScore W2413930958C16005928 @default.
- W2413930958 hasConceptScore W2413930958C180032290 @default.
- W2413930958 hasConceptScore W2413930958C198826908 @default.
- W2413930958 hasConceptScore W2413930958C203014093 @default.