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• W2413931229 abstract "Understanding the biological activities of riboswitches and of RNA in general requires a thorough analysis of both the spatial arrangement of the residues and the dynamics of the structural ensemble. Specifically, evaluating the structural basis for riboswitch function requires analyses of many relevant states that include ligand-bound and -free, high Mg(2+), and quite possibly, the active transcription state, which is challenging to achieve by most methods. Small angle X-ray scattering (SAXS) is an enabling technique for comprehensive analyses of RNA structures in solution. Here, we describe recent SAXS tools and technologies that substantially improve the potential for accurate and comprehensive analyses of flexibility, unstructured elements, conformational selection, and induced fit in RNA function. We note equipment needed plus appropriate annealing and purification procedures. We describe key model-independent parameters (SAXS invariants) which can be used to monitor changes in a particle's thermodynamic state: the Guinier-based Rg, the volume-of-correlation (Vc), the Porod-Debye exponent (P(E)), and the power-law parameter, Q(R), that determines mass directly from the SAXS data. We also consider the value of real-space parameters and of multiphase modeling with MONSA to locate secondary structure elements within SAXS volumetric envelopes. For conformation changes, experiments with nanogold-labeled RNA analyzed using the SAXS structural comparison map and volatility ratio difference metric enable high-throughput evaluation of solution-state conformations. Collectively, the described tools and procedures enable quantitative and comprehensive measures of riboswitch structures with general implications for our views and strategies of RNA structural analysis." @default.
• W2413931229 created "2016-06-24" @default.
• W2413931229 creator A5031435577 @default.
• W2413931229 creator A5038821821 @default.
• W2413931229 creator A5059713279 @default.
• W2413931229 creator A5074049459 @default.
• W2413931229 date "2014-01-01" @default.
• W2413931229 modified "2023-09-27" @default.
• W2413931229 title "Methods for Using New Conceptual Tools and Parameters to Assess RNA Structure by Small-Angle X-Ray Scattering" @default.
• W2413931229 cites W1966413464 @default.
• W2413931229 cites W1972339198 @default.
• W2413931229 cites W1974980928 @default.
• W2413931229 cites W1975008016 @default.
• W2413931229 cites W1977038370 @default.
• W2413931229 cites W1981809235 @default.
• W2413931229 cites W1984084102 @default.
• W2413931229 cites W1984530381 @default.
• W2413931229 cites W1984896911 @default.
• W2413931229 cites W1986888461 @default.
• W2413931229 cites W1991357892 @default.
• W2413931229 cites W1995586409 @default.
• W2413931229 cites W1995879438 @default.
• W2413931229 cites W1999218203 @default.
• W2413931229 cites W2005710177 @default.
• W2413931229 cites W2005877554 @default.
• W2413931229 cites W2012566319 @default.
• W2413931229 cites W2012778514 @default.
• W2413931229 cites W2014268727 @default.
• W2413931229 cites W2015210169 @default.
• W2413931229 cites W2018012741 @default.
• W2413931229 cites W2023447708 @default.
• W2413931229 cites W2024014666 @default.
• W2413931229 cites W2024947747 @default.
• W2413931229 cites W2025105411 @default.
• W2413931229 cites W2036297939 @default.
• W2413931229 cites W2037199390 @default.
• W2413931229 cites W2041728208 @default.
• W2413931229 cites W2044250235 @default.
• W2413931229 cites W2045194452 @default.
• W2413931229 cites W2051358253 @default.
• W2413931229 cites W2060104851 @default.
• W2413931229 cites W2061897019 @default.
• W2413931229 cites W2066088601 @default.
• W2413931229 cites W2066158357 @default.
• W2413931229 cites W2067947421 @default.
• W2413931229 cites W2069909250 @default.
• W2413931229 cites W2070293903 @default.
• W2413931229 cites W2070395446 @default.
• W2413931229 cites W2071842171 @default.
• W2413931229 cites W2072674961 @default.
• W2413931229 cites W2073418519 @default.
• W2413931229 cites W2076933884 @default.
• W2413931229 cites W2081826205 @default.
• W2413931229 cites W2083992260 @default.
• W2413931229 cites W2084388555 @default.
• W2413931229 cites W2084841438 @default.
• W2413931229 cites W2092706623 @default.
• W2413931229 cites W2093450576 @default.
• W2413931229 cites W2093605276 @default.
• W2413931229 cites W2096190151 @default.
• W2413931229 cites W2101809422 @default.
• W2413931229 cites W2110118545 @default.
• W2413931229 cites W2110680433 @default.
• W2413931229 cites W2111307988 @default.
• W2413931229 cites W2112278341 @default.
• W2413931229 cites W2115586221 @default.
• W2413931229 cites W2118102525 @default.
• W2413931229 cites W2121473677 @default.
• W2413931229 cites W2130779427 @default.
• W2413931229 cites W2133347507 @default.
• W2413931229 cites W2136868992 @default.
• W2413931229 cites W2142654956 @default.
• W2413931229 cites W2145707329 @default.
• W2413931229 cites W2149885731 @default.
• W2413931229 cites W2151313206 @default.
• W2413931229 cites W2153278581 @default.
• W2413931229 cites W2403912335 @default.
• W2413931229 cites W2411176406 @default.
• W2413931229 cites W40770424 @default.
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• W2413931229 doi "https://doi.org/10.1016/b978-0-12-801122-5.00011-8" @default.
• W2413931229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25432752" @default.
• W2413931229 hasPublicationYear "2014" @default.
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