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- W2413931970 abstract "Objective To detect the expression of human β-defensin 2(HBD-2)and tumor necrosis factor-α(TNF-α)in the colonic mucosae of ulcerative colitis(UC)patients and diarrheapredominant irritable bowel syndrome (IBS-D)patients and to evaluate the roles of HBD-2 and TNF-α in the pathogenesis and the relationship between them. Methods Immunohistochemistry was conducted on the biopsy samples of colonic mucosa from 30 UC patients, 20 IBS-D patients, and 10 normal persons to measure the expression of HBD-2 and TNF-α. Results The expression levels of HBD-2 and TNF-α in the colonic mncosa of UC were both significantly higher than those in the colonic mucosa of IBS-D (z=-4. 856, z=-3. 987, all P＜0. 01)and in the normal colonic mucosa(z=-3. 611, z=-3. 248, all P＜0. 01). But no significant differences were found between the colonic mucosa of IBS-D and the normal colonic mucosa in the intensity of the expressions of HBD-2 and TNF-α(z=-0. 373. z=-0. 032. all P＞0. 05). There were no significant differences in the intensity of the expressions of HBD-2 and TNF-α in colonic mucosa of among the mild, moderate, and severe UC(x2=1. 190、P＞0. 05, x2=1. 672、P＞0. 05). Conclusion The expressions of HBD-2 and TNF-α are significantly increased in UC, but are not correlated with IBS-D and the severity of clinical symptoms of UC patients. Key words: Colitis,ulcerative; Irritable bowel syndrome; beta-Defensins; Tumor necrosis factor-alpha" @default.
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- W2413931970 date "2008-04-08" @default.
- W2413931970 modified "2023-09-28" @default.
- W2413931970 title "[Expression of human beta-defensin 2 and tumor necrosis factor-A in colonic mucosae of ulcerative colitis and diarrhea-predominant irritable bowel syndrome]." @default.
- W2413931970 doi "https://doi.org/10.3321/j.issn:0376-2491.2008.14.006" @default.
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