Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414030654> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2414030654 endingPage "1934578X1501000" @default.
- W2414030654 startingPage "1934578X1501000" @default.
- W2414030654 abstract "Leishmaniasis is a neglected tropical disease caused by Leishmania parasitic protozoa, which currently lacks efficient treatment. Natural products have shown promise as a potential source for antiprotozoal drugs. This work focuses on the antileishmanial potential of Sassafras albidum (Lauraceae) bark extract. The crude bark extract of S. albidum showed excellent antileishmanial activity with an IC 50 value less than 12.5 μg/mL against promastigotes of L. amazonensis. The chloroform stem bark extract of S. albidum was subjected to preparative column chromatography. Five compounds were isolated, purified by recrystallization, and identified as sesamin, spinescin, β-sitosterol, hexatriacontanal, and 1-triacontanol. Antileishmanial and cytotoxic screening were performed on these compounds. Sesamin exhibited the best activity against L. amazonensis with an IC 50 of 15.8 μg/mL and was not cytotoxic to mouse macrophage cells ( CC 50 > 100 μg/mL)." @default.
- W2414030654 created "2016-06-24" @default.
- W2414030654 creator A5018338270 @default.
- W2414030654 creator A5040005212 @default.
- W2414030654 creator A5041946036 @default.
- W2414030654 creator A5081140387 @default.
- W2414030654 creator A5085972385 @default.
- W2414030654 date "2015-07-01" @default.
- W2414030654 modified "2023-10-01" @default.
- W2414030654 title "Antileishmanial Activity of Compounds Isolated from <i>Sassafras albidum</i>" @default.
- W2414030654 cites W130757427 @default.
- W2414030654 cites W1540493739 @default.
- W2414030654 cites W1980772387 @default.
- W2414030654 cites W2003459108 @default.
- W2414030654 cites W2014114084 @default.
- W2414030654 cites W2018017202 @default.
- W2414030654 cites W2030298145 @default.
- W2414030654 cites W2031788483 @default.
- W2414030654 cites W2034662800 @default.
- W2414030654 cites W2038922121 @default.
- W2414030654 cites W2047581463 @default.
- W2414030654 cites W2047699837 @default.
- W2414030654 cites W2068541511 @default.
- W2414030654 cites W2071258723 @default.
- W2414030654 cites W2089148248 @default.
- W2414030654 cites W2090458514 @default.
- W2414030654 cites W2107325026 @default.
- W2414030654 cites W2107915297 @default.
- W2414030654 cites W28535195 @default.
- W2414030654 cites W2935174213 @default.
- W2414030654 cites W2075481013 @default.
- W2414030654 doi "https://doi.org/10.1177/1934578x1501000723" @default.
- W2414030654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26411017" @default.
- W2414030654 hasPublicationYear "2015" @default.
- W2414030654 type Work @default.
- W2414030654 sameAs 2414030654 @default.
- W2414030654 citedByCount "4" @default.
- W2414030654 countsByYear W24140306542018 @default.
- W2414030654 countsByYear W24140306542021 @default.
- W2414030654 countsByYear W24140306542023 @default.
- W2414030654 crossrefType "journal-article" @default.
- W2414030654 hasAuthorship W2414030654A5018338270 @default.
- W2414030654 hasAuthorship W2414030654A5040005212 @default.
- W2414030654 hasAuthorship W2414030654A5041946036 @default.
- W2414030654 hasAuthorship W2414030654A5081140387 @default.
- W2414030654 hasAuthorship W2414030654A5085972385 @default.
- W2414030654 hasBestOaLocation W24140306541 @default.
- W2414030654 hasConcept C133446333 @default.
- W2414030654 hasConcept C185592680 @default.
- W2414030654 hasConcept C18903297 @default.
- W2414030654 hasConcept C202751555 @default.
- W2414030654 hasConcept C2776635100 @default.
- W2414030654 hasConcept C2778625465 @default.
- W2414030654 hasConcept C55493867 @default.
- W2414030654 hasConcept C556039675 @default.
- W2414030654 hasConcept C59822182 @default.
- W2414030654 hasConcept C71924100 @default.
- W2414030654 hasConcept C86803240 @default.
- W2414030654 hasConceptScore W2414030654C133446333 @default.
- W2414030654 hasConceptScore W2414030654C185592680 @default.
- W2414030654 hasConceptScore W2414030654C18903297 @default.
- W2414030654 hasConceptScore W2414030654C202751555 @default.
- W2414030654 hasConceptScore W2414030654C2776635100 @default.
- W2414030654 hasConceptScore W2414030654C2778625465 @default.
- W2414030654 hasConceptScore W2414030654C55493867 @default.
- W2414030654 hasConceptScore W2414030654C556039675 @default.
- W2414030654 hasConceptScore W2414030654C59822182 @default.
- W2414030654 hasConceptScore W2414030654C71924100 @default.
- W2414030654 hasConceptScore W2414030654C86803240 @default.
- W2414030654 hasIssue "7" @default.
- W2414030654 hasLocation W24140306541 @default.
- W2414030654 hasLocation W24140306542 @default.
- W2414030654 hasOpenAccess W2414030654 @default.
- W2414030654 hasPrimaryLocation W24140306541 @default.
- W2414030654 hasRelatedWork W168635608 @default.
- W2414030654 hasRelatedWork W2218737727 @default.
- W2414030654 hasRelatedWork W2397361477 @default.
- W2414030654 hasRelatedWork W2423378869 @default.
- W2414030654 hasRelatedWork W2444554946 @default.
- W2414030654 hasRelatedWork W2735873346 @default.
- W2414030654 hasRelatedWork W3123898844 @default.
- W2414030654 hasRelatedWork W3146058505 @default.
- W2414030654 hasRelatedWork W4376866755 @default.
- W2414030654 hasRelatedWork W2189202183 @default.
- W2414030654 hasVolume "10" @default.
- W2414030654 isParatext "false" @default.
- W2414030654 isRetracted "false" @default.
- W2414030654 magId "2414030654" @default.
- W2414030654 workType "article" @default.