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• W2414047865 abstract "Two genes control expression of mitochondrial carnitine palmitoyltransferase-I (CPT-I), the enzyme that catalyzes the primary rate-controlling step in fatty acid oxidation. Two CPT-I isoforms have been found--a liver isoform (CPT-Ialpha) expressed in most tissues, but not in skeletal muscles, and a muscle isoform (CPT-Ibeta) expressed in muscles and adipocytes. Liver CPT-Ialpha increases dramatically at birth, but heart CPT-Ialpha is abundant in the fetus and diminishes at birth. Insulin, thyroid hormone, and fatty acids regulate expression of CPT-Ialpha in liver, whereas electrical stimulation increases CPT-Ibeta and decreases CPT-Ialpha in cardiac myocytes. Both genes are TATA-less and contain Sp1 transcription factor binding sites upstream of the start site of transcription. Multiple transcripts of both CPT-Ialpha and CPT-Ibeta exist, some of which may have roles in regulating fatty acid oxidation." @default.
• W2414047865 created "2016-06-24" @default.
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• W2414047865 creator A5061158299 @default.
• W2414047865 date "1999-07-01" @default.
• W2414047865 modified "2023-10-06" @default.
• W2414047865 title "Expression and Regulation of Carnitine Palmitoyltransferase-I?? and -I?? Genes" @default.
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• W2414047865 doi "https://doi.org/10.1097/00000441-199907000-00007" @default.
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