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- W2414052523 abstract "The effects of the mu-agonists morphine and DAGO, the delta-agonists D-Pen2, D-Pen5-enkephaline and dalargine and the kappa-agonists U50-488H and dynophine 1-17 on the activity of the spinal dorsal horn neurons receiving both cutaneous and visceral nociceptive inputs were studied. The experiments were performed under chloralose anesthesia in flaxedyl-immobilized rats. Morphine (10(-6)-10(-5) M) and DAGO (5 x 10(-7)-10(-6)) given pneumophoretically or topically onto the spinal cord suppressed the activity evoked by cutaneous nociceptive stimulation to a greater extent than those used by the nociceptive stimulation of the colon and rectum. Intravenous morphine (3-12 mg/kg) suppressed the activity caused by somatic and visceral stimulation to approximately the same extent. The delta-agonists D-Pen2, D-Pen5-enkephaline (10(-6)-10(-5) M) and delargin (10(-6)-10(-5) M) administered pneumophoretically or locally produced the effects similar to those of mu-agonists. All these effects were concentration-dependent and naloxone-sensitive. The kappa-agonists U50-488N (10(-4) M) and dynorphine (10(-4) M) failed to suppress the nociceptive responses of convergent neurons." @default.
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- W2414052523 date "1993-01-01" @default.
- W2414052523 modified "2023-09-23" @default.
- W2414052523 title "[The effect of mu-, delta- and kappa-opiate receptor agonists on the bioelectrical activity of the viscerosomatic convergent neurons in the posterior horn of the spinal cord]." @default.
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