FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414076275> ?p ?o ?g. }

• W2414076275 abstract "Abstract Expression analysis and variant calling workflows are employed to identify genes that either exhibit a differential behaviour or have a significant functional impact of mutations. This is always followed by pathway analysis which provides greater insights and simplifies explanation of observed phenotype. The current techniques used towards this purpose have some serious limitations. Only a small number of genes which satisfy certain thresholds are used for pathway analysis. All the shortlisted genes are treated as equal ignoring the differences in p-values and fold changes. These genes are treated as independent entities and interactions among them are ignored for statistical pathway analysis. Hence, there is serious disconnect between the techniques employed and networked nature of the data. Various Pathway data ases have great degree of discordance on structure of pathway graphs. Many of the pathways are still far from complete. Current algorithms do not take into account this uncertainty. In this paper, we propose a theoretical framework Prius to overcome many limitations of current techniques. Prius perturbs the gene expression fold changes through interaction network and generates an ordered list of affected pathways. Thus, it integrates the networked nature of the data and provides facility to weigh each gene differently and in the process we do away with the need of arbitrary cut-offs. This framework is designed to be modular and provides the researchers with flexibility to plug analytical tools of their choice for every component. We also demonstrate effectiveness of our approach for personalized and cohort analysis of cancer gene expression samples with PageRank as one of the modules in the framework. The R package for Prius is available on GitHub." @default.
• W2414076275 created "2016-06-24" @default.
• W2414076275 creator A5000722519 @default.
• W2414076275 creator A5014921992 @default.
• W2414076275 creator A5067581384 @default.
• W2414076275 date "2016-02-07" @default.
• W2414076275 modified "2023-09-27" @default.
• W2414076275 title "Prius: From Differentiated Genes to Affected Pathways" @default.
• W2414076275 cites W1980740976 @default.
• W2414076275 cites W1983463159 @default.
• W2414076275 cites W2059145105 @default.
• W2414076275 cites W2100980426 @default.
• W2414076275 cites W2105666627 @default.
• W2414076275 cites W2109912704 @default.
• W2414076275 cites W2110687686 @default.
• W2414076275 cites W2111326065 @default.
• W2414076275 cites W2133465414 @default.
• W2414076275 cites W2144780381 @default.
• W2414076275 cites W2151470713 @default.
• W2414076275 cites W2152176732 @default.
• W2414076275 doi "https://doi.org/10.1101/038901" @default.
• W2414076275 hasPublicationYear "2016" @default.
• W2414076275 type Work @default.
• W2414076275 sameAs 2414076275 @default.
• W2414076275 citedByCount "0" @default.
• W2414076275 crossrefType "posted-content" @default.
• W2414076275 hasAuthorship W2414076275A5000722519 @default.
• W2414076275 hasAuthorship W2414076275A5014921992 @default.
• W2414076275 hasAuthorship W2414076275A5067581384 @default.
• W2414076275 hasBestOaLocation W24140762751 @default.
• W2414076275 hasConcept C101468663 @default.
• W2414076275 hasConcept C104317684 @default.
• W2414076275 hasConcept C105795698 @default.
• W2414076275 hasConcept C121332964 @default.
• W2414076275 hasConcept C124101348 @default.
• W2414076275 hasConcept C127413603 @default.
• W2414076275 hasConcept C146978453 @default.
• W2414076275 hasConcept C168167062 @default.
• W2414076275 hasConcept C177212765 @default.
• W2414076275 hasConcept C199360897 @default.
• W2414076275 hasConcept C2779172887 @default.
• W2414076275 hasConcept C2780598303 @default.
• W2414076275 hasConcept C33923547 @default.
• W2414076275 hasConcept C41008148 @default.
• W2414076275 hasConcept C54355233 @default.
• W2414076275 hasConcept C70721500 @default.
• W2414076275 hasConcept C77088390 @default.
• W2414076275 hasConcept C80444323 @default.
• W2414076275 hasConcept C86803240 @default.
• W2414076275 hasConcept C93226319 @default.
• W2414076275 hasConcept C97355855 @default.
• W2414076275 hasConcept C98045186 @default.
• W2414076275 hasConceptScore W2414076275C101468663 @default.
• W2414076275 hasConceptScore W2414076275C104317684 @default.
• W2414076275 hasConceptScore W2414076275C105795698 @default.
• W2414076275 hasConceptScore W2414076275C121332964 @default.
• W2414076275 hasConceptScore W2414076275C124101348 @default.
• W2414076275 hasConceptScore W2414076275C127413603 @default.
• W2414076275 hasConceptScore W2414076275C146978453 @default.
• W2414076275 hasConceptScore W2414076275C168167062 @default.
• W2414076275 hasConceptScore W2414076275C177212765 @default.
• W2414076275 hasConceptScore W2414076275C199360897 @default.
• W2414076275 hasConceptScore W2414076275C2779172887 @default.
• W2414076275 hasConceptScore W2414076275C2780598303 @default.
• W2414076275 hasConceptScore W2414076275C33923547 @default.
• W2414076275 hasConceptScore W2414076275C41008148 @default.
• W2414076275 hasConceptScore W2414076275C54355233 @default.
• W2414076275 hasConceptScore W2414076275C70721500 @default.
• W2414076275 hasConceptScore W2414076275C77088390 @default.
• W2414076275 hasConceptScore W2414076275C80444323 @default.
• W2414076275 hasConceptScore W2414076275C86803240 @default.
• W2414076275 hasConceptScore W2414076275C93226319 @default.
• W2414076275 hasConceptScore W2414076275C97355855 @default.
• W2414076275 hasConceptScore W2414076275C98045186 @default.
• W2414076275 hasLocation W24140762751 @default.
• W2414076275 hasOpenAccess W2414076275 @default.
• W2414076275 hasPrimaryLocation W24140762751 @default.
• W2414076275 hasRelatedWork W132211227 @default.
• W2414076275 hasRelatedWork W1547959233 @default.
• W2414076275 hasRelatedWork W1668412471 @default.
• W2414076275 hasRelatedWork W1906929995 @default.
• W2414076275 hasRelatedWork W2006459600 @default.
• W2414076275 hasRelatedWork W2042703493 @default.
• W2414076275 hasRelatedWork W2057053591 @default.
• W2414076275 hasRelatedWork W2166667584 @default.
• W2414076275 hasRelatedWork W2397984754 @default.
• W2414076275 hasRelatedWork W2414076275 @default.
• W2414076275 hasRelatedWork W2473338842 @default.
• W2414076275 hasRelatedWork W2530183663 @default.
• W2414076275 hasRelatedWork W2558781506 @default.
• W2414076275 hasRelatedWork W2583580135 @default.
• W2414076275 hasRelatedWork W2739856923 @default.
• W2414076275 hasRelatedWork W2904351124 @default.
• W2414076275 hasRelatedWork W2905944409 @default.
• W2414076275 hasRelatedWork W2949793923 @default.
• W2414076275 hasRelatedWork W3092950961 @default.
• W2414076275 hasRelatedWork W3195991557 @default.
• W2414076275 isParatext "false" @default.
• W2414076275 isRetracted "false" @default.
• W2414076275 magId "2414076275" @default.

• next