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- W2414084612 abstract "The paper is concerned with activation of cyclophosphamide by mouse liver microsomes in vitro. Liver microsomes from BALB/c mice metabolize cyclophosphamide more effectively as compared with those from DBA/2 mice, which manifested by a more intense output of products having alkylating or immunodepressant properties. This seems likely to be a consequence of the increased P-450 cytochrome content in liver microsomes from BALB/c mice, as well as of its structural characteristics in the mouse. The relationship between the immunodepressant effect of cyclophosphamide in vivo and in vitro in mice of varied genotypes is discussed." @default.
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- W2414084612 date "1981-07-01" @default.
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- W2414084612 title "[Immunosuppressant effect of cyclophosphamide activated in vitro by liver microsomes from different strains of mice]." @default.
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