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• W2414103687 abstract "Radiology now. Fast neutrons—clinical requirementsPublished Online:28 Jan 2014https://doi.org/10.1259/0007-1285-49-579-203SectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail AboutAbstractFor decades, there have been numerous treatments for cancer and recently a plethora of drugs has added almost limitless possibilities to these. When fast neutrons became available clinically, there was, understandably, a demand for their effects to be compared objectively with conventional radiation.The precision and efficiency of modern megavoltage X- and γ-ray machines, and their ability to deliver an exact dose of radiation to the volume delineated, probably cannot be improved upon, and usually exceeds the ability of the clinician to localize the extent of the malignancy. Output of radiation is so good that treatment times are of the order of one to three minutes, and well-defined beams can be directed in any direction and in any plane. Patients can be treated in the most suitable of many possible positions and do not usually suffer skin reactions. Megavoltage machines are situated within hospitals and are available in most centres throughout the world where physicists and clinicians have wide experience in their use.In contrast, all existing neutron sources suffer from serious disadvantages. For instance, in the U.S.A., patients from the M.D. Anderson Hospital are transported 100 miles into Texas for each treatment. The M.R.C. Cyclotron in Hammersmith Hospital has a neutron beam which is fixed in the horizontal position and is collimated in squares or rectangles of fixed sizes. The energy (7·5 MeV) gives a dose distribution only slightly better than 250 kV X rays and the isodoses are rounded at the ends and show a clinically significant penumbra. Next article FiguresReferencesRelatedDetailsCited byEvaluating the dependency of neutron spectra and absorbed dose rates on the collimation field size in fast neutron therapyHeliyon, Vol. 7, No. 11The dependency of fast neutron flux and spectra on the collimation-field size and geometry for fast neutron therapy purposes29 July 2021 | Radiation Effects and Defects in Solids, Vol. 99Fast neutron therapyThe Clatterbridge high-energy neutron therapy facility: specification and performanceD. E. Bonnett, S. W. Blake, J. E. Shaw and D. K. Bewley28 January 2014 | The British Journal of Radiology, Vol. 61, No. 721Neutron beam characteristics from 50 MeV protons on beryllium using a continuously variable multi-leaf collimatorRadiotherapy and Oncology, Vol. 1, No. 1Progress in Neutron Dosimetry for Biomedical ApplicationsThree-dimensional CT and structure modelsC. Alberti28 January 2014 | The British Journal of Radiology, Vol. 53, No. 627Neutron sources for cancer therapyL. Cranberg28 January 2014 | The British Journal of Radiology, Vol. 53, No. 627Radionuclide cystography vs. micturating cystourethrography for diagnosing vesico-ureteric reflux in childrenS. T. Meller, B. C. H. Ward and H. B. Eckstein28 January 2014 | The British Journal of Radiology, Vol. 53, No. 627The Use of Compact Cyclotrons for Producing Fast Neutrons for Therapy in a Rotatable Isocentric GantryIEEE Transactions on Nuclear Science, Vol. 26, No. 2History of the use of neutrons in radiation therapyInternational Journal of Radiation Oncology*Biology*Physics, Vol. 3The results of randomised and other clinical trials of fast neutrons from the medical research council cyclotron, LondonInternational Journal of Radiation Oncology*Biology*Physics, Vol. 3The future neutron therapy clinical trials in the united statesInternational Journal of Radiation Oncology*Biology*Physics, Vol. 3Superconducting cyclotron neutron source for therapyInternational Journal of Radiation Oncology*Biology*Physics, Vol. 3 Volume 49, Issue 579March 1976Pages: 203-302 © The British Institute of Radiology History Published onlineJanuary 28,2014 Metrics Download PDF" @default.
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