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- W2414157519 abstract "During urinary tract infection (UTI), the second most common bacterial infection, dynamic interactions take place between uropathogenic E. coli (UPEC) and host urothelial cells. While significant strides have been made in the identification of the virulence factors of UPEC, our understanding of how the urothelial cells mobilize innate defenses against the invading UPEC remains rudimentary. Here we show that mouse urothelium responds to the adhesion of type 1-fimbriated UPEC by rapidly activating the canonical NF-κB selectively in terminally differentiated, superficial (umbrella) cells. This activation depends on a dual ligand/receptor system, one between FimH adhesin and uroplakin Ia and another between lipopolysaccharide and Toll-like receptor 4. When activated, all the nuclei (up to 11) of a multinucleated umbrella cell are affected, leading to significant amplification of proinflammatory signals. Intermediate and basal cells of the urothelium undergo NF-κB activation only if the umbrella cells are detached or if the UPEC persistently express type 1-fimbriae. Inhibition of NF-κB prevents the urothelium from clearing the intracellular bacterial communities, leading to prolonged bladder colonization by UPEC. Based on these data, we propose a model of dual ligand/receptor system in innate urothelial defenses against UPEC." @default.
- W2414157519 created "2016-06-24" @default.
- W2414157519 creator A5003048872 @default.
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- W2414157519 date "2015-11-09" @default.
- W2414157519 modified "2023-09-25" @default.
- W2414157519 title "Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli" @default.
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- W2414157519 cites W1772212485 @default.
- W2414157519 cites W1817295032 @default.
- W2414157519 cites W1828234834 @default.
- W2414157519 cites W1830586057 @default.
- W2414157519 cites W1869191601 @default.
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- W2414157519 cites W1906639127 @default.
- W2414157519 cites W1911301755 @default.
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- W2414157519 cites W1967961996 @default.
- W2414157519 cites W1980273234 @default.
- W2414157519 cites W1984755921 @default.
- W2414157519 cites W1987718502 @default.
- W2414157519 cites W1993415901 @default.
- W2414157519 cites W1995025776 @default.
- W2414157519 cites W1996053208 @default.
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- W2414157519 cites W2029973586 @default.
- W2414157519 cites W2031743395 @default.
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- W2414157519 cites W2075138163 @default.
- W2414157519 cites W2087285822 @default.
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- W2414157519 cites W2096278211 @default.
- W2414157519 cites W2096724446 @default.
- W2414157519 cites W2102353091 @default.
- W2414157519 cites W2108517025 @default.
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- W2414157519 cites W2111351802 @default.
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- W2414157519 cites W2130747578 @default.
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- W2414157519 cites W2136535932 @default.
- W2414157519 cites W2138304410 @default.
- W2414157519 cites W2138651252 @default.
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- W2414157519 cites W2150533610 @default.
- W2414157519 cites W2151251464 @default.
- W2414157519 cites W2153435059 @default.
- W2414157519 cites W2153476198 @default.
- W2414157519 cites W2154535399 @default.
- W2414157519 cites W2154900915 @default.
- W2414157519 cites W2155415498 @default.
- W2414157519 cites W2157117327 @default.
- W2414157519 cites W2157541854 @default.
- W2414157519 cites W2159723852 @default.
- W2414157519 cites W2162749433 @default.
- W2414157519 cites W2163387042 @default.
- W2414157519 cites W2163515175 @default.
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- W2414157519 cites W2167430913 @default.
- W2414157519 cites W2189762700 @default.
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- W2414157519 doi "https://doi.org/10.1038/srep16234" @default.
- W2414157519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4637824" @default.
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- W2414157519 hasPublicationYear "2015" @default.
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