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- W2414193471 abstract "DNA replication is an extremely complex process that needs to be executed in a highly accurate manner in order to propagate the genome. This task requires the coordination of a number of enzymatic activities and it is incredibly fragile and prone to arrest after DNA damage. DNA damage tolerance provides a last line of defense that allows completion of DNA replication in presence of an unrepaired template. One of such mechanisms is called Post Replication Repair (PRR) and it is used by the cells to bypass highly distorted templates caused by damaged bases. PRR is extremely important for the cellular life and performs the bypass of the damage both in an error free and in an error prone manner. In light of these two possible outcomes, PRR needs to be tightly regulated and controlled in order to prevent accumulation of mutations leading ultimately to genome instability. Post-translational modifications provide the framework for this regulation and Ubiquitylation and SUMOylation of PRR proteins play a pivotal role in choosing which pathway to activate, controlling the different outcomes of damage bypass. PCNA (Proliferating Cell Nuclear Antigen), the DNA clamp for replicative polymerases, plays a central role in the regulation of damage tolerance and its modification by Ubiquitin and SUMO controls both the error free and error prone branches of PRR. Furthermore, a significant number of polymerases involved in the bypass of DNA damage possess domains that can bind post-translational modifications and they are themselves target for ubiquitylation. In this review, we will focus on how Ubiquitin and Ubiquitin-like modifications can regulate the DNA damage tolerance systems and how they are capable of controlling the recruitment of different proteins to the replication fork." @default.
- W2414193471 created "2016-06-24" @default.
- W2414193471 creator A5001597536 @default.
- W2414193471 creator A5016567243 @default.
- W2414193471 creator A5035342442 @default.
- W2414193471 creator A5079648273 @default.
- W2414193471 date "2016-06-13" @default.
- W2414193471 modified "2023-10-03" @default.
- W2414193471 title "The Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like Modifiers" @default.
- W2414193471 cites W1486866108 @default.
- W2414193471 cites W1531823089 @default.
- W2414193471 cites W1545435534 @default.
- W2414193471 cites W1693881617 @default.
- W2414193471 cites W1794195058 @default.
- W2414193471 cites W1822321004 @default.
- W2414193471 cites W1840855988 @default.
- W2414193471 cites W1965011585 @default.
- W2414193471 cites W1965818711 @default.
- W2414193471 cites W1966240299 @default.
- W2414193471 cites W1967186447 @default.
- W2414193471 cites W1969827604 @default.
- W2414193471 cites W1972687365 @default.
- W2414193471 cites W1974226240 @default.
- W2414193471 cites W1974796017 @default.
- W2414193471 cites W1978753758 @default.
- W2414193471 cites W1978982015 @default.
- W2414193471 cites W1979445270 @default.
- W2414193471 cites W1980468156 @default.
- W2414193471 cites W1980745500 @default.
- W2414193471 cites W1982770423 @default.
- W2414193471 cites W1984320346 @default.
- W2414193471 cites W1985146373 @default.
- W2414193471 cites W1985563834 @default.
- W2414193471 cites W1989134143 @default.
- W2414193471 cites W1989643386 @default.
- W2414193471 cites W1991296165 @default.
- W2414193471 cites W1994183109 @default.
- W2414193471 cites W1994502400 @default.
- W2414193471 cites W1998367296 @default.
- W2414193471 cites W1998600338 @default.
- W2414193471 cites W2001834505 @default.
- W2414193471 cites W2008207745 @default.
- W2414193471 cites W2008412865 @default.
- W2414193471 cites W2011580988 @default.
- W2414193471 cites W2012012836 @default.
- W2414193471 cites W2012935049 @default.
- W2414193471 cites W2013289317 @default.
- W2414193471 cites W2014989563 @default.
- W2414193471 cites W2016758355 @default.
- W2414193471 cites W2018293376 @default.
- W2414193471 cites W2019373567 @default.
- W2414193471 cites W2019642759 @default.
- W2414193471 cites W2020136215 @default.
- W2414193471 cites W2020754261 @default.
- W2414193471 cites W2022190569 @default.
- W2414193471 cites W2024380558 @default.
- W2414193471 cites W2028518981 @default.
- W2414193471 cites W2029317616 @default.
- W2414193471 cites W2032167553 @default.
- W2414193471 cites W2032610349 @default.
- W2414193471 cites W2033495606 @default.
- W2414193471 cites W2034246488 @default.
- W2414193471 cites W2036027601 @default.
- W2414193471 cites W2036826205 @default.
- W2414193471 cites W2037936898 @default.
- W2414193471 cites W2039693737 @default.
- W2414193471 cites W2039780502 @default.
- W2414193471 cites W2040350157 @default.
- W2414193471 cites W2041249795 @default.
- W2414193471 cites W2042488015 @default.
- W2414193471 cites W2042970469 @default.
- W2414193471 cites W2044460749 @default.
- W2414193471 cites W2044856539 @default.
- W2414193471 cites W2045448966 @default.
- W2414193471 cites W2048712749 @default.
- W2414193471 cites W2053597010 @default.
- W2414193471 cites W2055390996 @default.
- W2414193471 cites W2055400238 @default.
- W2414193471 cites W2055980504 @default.
- W2414193471 cites W2056139483 @default.
- W2414193471 cites W2056622279 @default.
- W2414193471 cites W2056870028 @default.
- W2414193471 cites W2058893570 @default.
- W2414193471 cites W2059227077 @default.
- W2414193471 cites W2063280340 @default.
- W2414193471 cites W2065826174 @default.
- W2414193471 cites W2066948825 @default.
- W2414193471 cites W2067463001 @default.
- W2414193471 cites W2068832995 @default.
- W2414193471 cites W2072280896 @default.
- W2414193471 cites W2073294832 @default.
- W2414193471 cites W2077436902 @default.
- W2414193471 cites W2078485114 @default.
- W2414193471 cites W2079269391 @default.
- W2414193471 cites W2080378383 @default.
- W2414193471 cites W2080978652 @default.
- W2414193471 cites W2094132637 @default.
- W2414193471 cites W2095424116 @default.
- W2414193471 cites W2096136751 @default.
- W2414193471 cites W2096625253 @default.