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- W2414207088 abstract "Two grams of pancreatic extract increased the urinary excretion of labeled vitamin B12 from 2.0% ± 0.5 to 15.4% ± 2.0 (mean ± se ) in 7 patients with pancreatic exocrine insufficiency, but had no effect when administered to normal volunteers or to patients with vitamin B12 malabsorption associated with pernicious anemia, bacterial overgrowth, or drug-induced disease. The administration of pancreatic extract was useful in clarifying the cause of vitamin B12 malabsorption unresponsive to gastric intrinsic factor in 2 patients. One patient had a history of acute pancreatitis, but no clinical or laboratory evidence of chronic pancreatic exocrine insufficiency. In a 2nd patient with pernicious anemia, vitamin B12 absorption was restored to normal only when pancreatic extract and gastric intrinsic factor were administered concomitantly. The presence of pancreatic dysfunction was confirmed by the demonstration of impaired bicarbonate output after secretin stimulation. Thus, pancreatic extract responsive-vitamin B12 malabsorption is specific for the vitamin B12 malabsorption associated with pancreatic disease, can occur in the absence of overt pancreatic disease, and may be the only indication of pancreatic dysfunction." @default.
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- W2414207088 date "1973-08-01" @default.
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- W2414207088 title "Specificity of the Correction of Vitamin B12 Malabsorption by Pancreatic Extract and its Clinical Significance" @default.
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- W2414207088 doi "https://doi.org/10.1016/s0016-5085(19)33099-9" @default.
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