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- W2414223405 abstract "In order to investigate the characteristics of anion exchange resins that may safely and effectively bind dietary phosphate in digestive tract, phosphate binding experiments were carried out in vitro and in vivo with normal rats by comparing anion exchange resins, PAA-B (which has the same chemical structure as Sevelamer® HCl) and Dowe 1x8, with CaCO 3 . In in vitro phosphate binding experiments, PAA-B bound 32.3% less phosphate than CaCO 3 at pH 7. In the rat dietary phosphorus excretion experiments, PAA-B, Dowex 1x8, and CaCO 3 increased fecal phosphorus excretion by 62.7, 32.3, and 84.0%, respectively. Famotidine significantly reduced the phosphate binding of CaCO 3 . When phosphate solution was orally adiministered, PAA-B depressed serum phosphorus augmentations immediately after administration and thereafter effectively depressed serum iPTH. This suggests that anion exchange resins with most primary and secondary amino type anion exchange groups, have bright prospects in the treatment of hyperphosphatemia. (Int J Artif Organs 2000; 23: 243–9)" @default.
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- W2414223405 date "2000-04-01" @default.
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- W2414223405 title "Effects of Anion Exchange Resin as Phosphate Binder on Serum Phosphate and Ipth Levels in Normal Rats" @default.
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- W2414223405 doi "https://doi.org/10.1177/039139880002300406" @default.
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