FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414233691> ?p ?o ?g. }

• W2414233691 endingPage "559" @default.
• W2414233691 startingPage "553" @default.
• W2414233691 abstract "Alcoholic cardiomyopathy has been known for a long time, but there is little mechanistic insight into this important clinical problem. The present study was undertaken using a mouse model to test the hypothesis that alcohol exposure induces cardiac injury through induction of oxidative stress. Adult female Friend Virius B-type (FVB) mice were treated with ethanol by gavage at a dose of 5 g/kg. Six hours after the treatment, ethanol-induced myocardial injury was observed, as indicated by a significant increase in serum creatine phosphokinase activity, a common biomarker of myocardial injury, and myocardial ultrastructural alterations, predominantly mitochondrial swelling and cristae disarray and reduction in numbers. The myocardial injury was associated with a significant increase in the myocardial lipid peroxidation, determined by measuring thiobarbituric acid reactive substances (TBARS), and a significant increase in protein oxidation as measured by a protein carbonyl content assay. Acute alcohol exposure decreased glutathione (GSH) content in the heart, more so in the mitochondria than in the cytosol. These alcohol-induced myocardial injuries and oxidative stresses were all significantly inhibited by supplementation with N-acetyl-L-cysteine (NAC) prior to alcohol exposure. However, NAC did not affect the rise in blood alcohol concentrations following alcohol exposure. This study thus demonstrates that acute alcohol administration causes myocardial injury through, at least in part, the induction of oxidative stress. A rapid decrease in mitochondrial GSH content may be partially responsible for the observed mitochondrial damage." @default.
• W2414233691 created "2016-06-24" @default.
• W2414233691 creator A5033347843 @default.
• W2414233691 creator A5037488697 @default.
• W2414233691 creator A5082192610 @default.
• W2414233691 date "2004-06-01" @default.
• W2414233691 modified "2023-09-23" @default.
• W2414233691 title "Myocardial Oxidative Stress and Toxicity Induced by Acute Ethanol Exposure in Mice" @default.
• W2414233691 cites W1512705089 @default.
• W2414233691 cites W1968261026 @default.
• W2414233691 cites W1973363737 @default.
• W2414233691 cites W1974236856 @default.
• W2414233691 cites W1982567676 @default.
• W2414233691 cites W1992813824 @default.
• W2414233691 cites W2001872008 @default.
• W2414233691 cites W2002630124 @default.
• W2414233691 cites W2025223586 @default.
• W2414233691 cites W2033778527 @default.
• W2414233691 cites W2038156713 @default.
• W2414233691 cites W2040321594 @default.
• W2414233691 cites W2046402698 @default.
• W2414233691 cites W2060452153 @default.
• W2414233691 cites W2061998385 @default.
• W2414233691 cites W2068474466 @default.
• W2414233691 cites W2070371162 @default.
• W2414233691 cites W2071906706 @default.
• W2414233691 cites W2075069609 @default.
• W2414233691 cites W2080429981 @default.
• W2414233691 cites W2086319830 @default.
• W2414233691 cites W2086486507 @default.
• W2414233691 cites W2124816752 @default.
• W2414233691 cites W2126609164 @default.
• W2414233691 cites W2147525297 @default.
• W2414233691 cites W2160669163 @default.
• W2414233691 cites W2248087544 @default.
• W2414233691 cites W2254959160 @default.
• W2414233691 cites W2286177620 @default.
• W2414233691 cites W2340342319 @default.
• W2414233691 cites W4238463235 @default.
• W2414233691 cites W4245957869 @default.
• W2414233691 doi "https://doi.org/10.1177/153537020422900614" @default.
• W2414233691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15169975" @default.
• W2414233691 hasPublicationYear "2004" @default.
• W2414233691 type Work @default.
• W2414233691 sameAs 2414233691 @default.
• W2414233691 citedByCount "72" @default.
• W2414233691 countsByYear W24142336912012 @default.
• W2414233691 countsByYear W24142336912013 @default.
• W2414233691 countsByYear W24142336912014 @default.
• W2414233691 countsByYear W24142336912015 @default.
• W2414233691 countsByYear W24142336912016 @default.
• W2414233691 countsByYear W24142336912017 @default.
• W2414233691 countsByYear W24142336912018 @default.
• W2414233691 countsByYear W24142336912019 @default.
• W2414233691 countsByYear W24142336912021 @default.
• W2414233691 countsByYear W24142336912022 @default.
• W2414233691 crossrefType "journal-article" @default.
• W2414233691 hasAuthorship W2414233691A5033347843 @default.
• W2414233691 hasAuthorship W2414233691A5037488697 @default.
• W2414233691 hasAuthorship W2414233691A5082192610 @default.
• W2414233691 hasConcept C116263406 @default.
• W2414233691 hasConcept C126322002 @default.
• W2414233691 hasConcept C134018914 @default.
• W2414233691 hasConcept C181199279 @default.
• W2414233691 hasConcept C185592680 @default.
• W2414233691 hasConcept C2776151105 @default.
• W2414233691 hasConcept C2777352226 @default.
• W2414233691 hasConcept C2777873954 @default.
• W2414233691 hasConcept C2778198053 @default.
• W2414233691 hasConcept C2778797674 @default.
• W2414233691 hasConcept C2780161600 @default.
• W2414233691 hasConcept C2780829032 @default.
• W2414233691 hasConcept C2781066024 @default.
• W2414233691 hasConcept C28859421 @default.
• W2414233691 hasConcept C29730261 @default.
• W2414233691 hasConcept C36880943 @default.
• W2414233691 hasConcept C538909803 @default.
• W2414233691 hasConcept C55493867 @default.
• W2414233691 hasConcept C57600042 @default.
• W2414233691 hasConcept C71924100 @default.
• W2414233691 hasConcept C98274493 @default.
• W2414233691 hasConceptScore W2414233691C116263406 @default.
• W2414233691 hasConceptScore W2414233691C126322002 @default.
• W2414233691 hasConceptScore W2414233691C134018914 @default.
• W2414233691 hasConceptScore W2414233691C181199279 @default.
• W2414233691 hasConceptScore W2414233691C185592680 @default.
• W2414233691 hasConceptScore W2414233691C2776151105 @default.
• W2414233691 hasConceptScore W2414233691C2777352226 @default.
• W2414233691 hasConceptScore W2414233691C2777873954 @default.
• W2414233691 hasConceptScore W2414233691C2778198053 @default.
• W2414233691 hasConceptScore W2414233691C2778797674 @default.
• W2414233691 hasConceptScore W2414233691C2780161600 @default.
• W2414233691 hasConceptScore W2414233691C2780829032 @default.
• W2414233691 hasConceptScore W2414233691C2781066024 @default.
• W2414233691 hasConceptScore W2414233691C28859421 @default.
• W2414233691 hasConceptScore W2414233691C29730261 @default.
• W2414233691 hasConceptScore W2414233691C36880943 @default.
• W2414233691 hasConceptScore W2414233691C538909803 @default.

• next