Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414236137> ?p ?o ?g. }
- W2414236137 endingPage "1134" @default.
- W2414236137 startingPage "1125" @default.
- W2414236137 abstract "Introduction: Anti-sense oligonucleotide (ASO) therapies are a new development in clinical pharmacology offering greater specificity compared to small molecule inhibitors and the ability to target intracellular process’ not susceptible to antibody-based therapies.Areas covered: This article reviews the chemical biology of ASOs and related RNA therapeutics. It then reviews the data on their use to treat hyperlipidaemia. Data on mipomersen – an ASO to apolipoprotein B-100(apoB) licensed for treatment of homozygous familial hypercholesterolaemia (FH) is presented. Few effective therapies are available to reduce atehrogenic lipoprotein (a) levels. An ASO therapy to apolipoprotein(a) (ISIS Apo(a)Rx) specifically reduced lipoprotein (a) levels by up to 78%. Treatment options for patients with familial chylomicronaemia syndrome (lipoprotein lipase deficiency; LPLD) or lipodystrophies are highly limited and often inadequate. Volanesorsen, an ASO to apolipoprotein C-3, shows promise in the treatment of LPLD and severe hypertriglyceridaemia as it increases clearance of triglyceride-rich lipoproteins and can normalise triglycerides in these patients.Expert opinion: The uptake of the novel ASO therapies is likely to be limited to selected niche groups or orphan diseases. These will include homozygous FH, severe heterozygous FH for mipomersen; LPLD deficiency and lipodystrophy syndromes for volanesorsen and treatment of patients with high elevated Lp(a) levels." @default.
- W2414236137 created "2016-06-24" @default.
- W2414236137 creator A5066079193 @default.
- W2414236137 creator A5070756199 @default.
- W2414236137 date "2016-06-09" @default.
- W2414236137 modified "2023-09-26" @default.
- W2414236137 title "Anti-sense oligonucleotide therapies for the treatment of hyperlipidaemia" @default.
- W2414236137 cites W1520609538 @default.
- W2414236137 cites W1708837772 @default.
- W2414236137 cites W1832285227 @default.
- W2414236137 cites W1870321215 @default.
- W2414236137 cites W1968949098 @default.
- W2414236137 cites W1973740761 @default.
- W2414236137 cites W1976094170 @default.
- W2414236137 cites W198828404 @default.
- W2414236137 cites W1990204315 @default.
- W2414236137 cites W1990548509 @default.
- W2414236137 cites W2000280951 @default.
- W2414236137 cites W2001314633 @default.
- W2414236137 cites W2005935428 @default.
- W2414236137 cites W2026312571 @default.
- W2414236137 cites W2029397995 @default.
- W2414236137 cites W2030551858 @default.
- W2414236137 cites W2032456325 @default.
- W2414236137 cites W2043461445 @default.
- W2414236137 cites W2047043150 @default.
- W2414236137 cites W2048760408 @default.
- W2414236137 cites W2049303193 @default.
- W2414236137 cites W2052644460 @default.
- W2414236137 cites W2053710703 @default.
- W2414236137 cites W2058745674 @default.
- W2414236137 cites W2060264439 @default.
- W2414236137 cites W2064706592 @default.
- W2414236137 cites W2066859359 @default.
- W2414236137 cites W2073115409 @default.
- W2414236137 cites W2077416096 @default.
- W2414236137 cites W2079358053 @default.
- W2414236137 cites W2086153196 @default.
- W2414236137 cites W2092412521 @default.
- W2414236137 cites W2096210401 @default.
- W2414236137 cites W2097979418 @default.
- W2414236137 cites W2098890974 @default.
- W2414236137 cites W2104290329 @default.
- W2414236137 cites W2106951652 @default.
- W2414236137 cites W2114182408 @default.
- W2414236137 cites W2115715697 @default.
- W2414236137 cites W2120090218 @default.
- W2414236137 cites W2121752750 @default.
- W2414236137 cites W2123366371 @default.
- W2414236137 cites W2123693283 @default.
- W2414236137 cites W2124481954 @default.
- W2414236137 cites W2129132730 @default.
- W2414236137 cites W2131620609 @default.
- W2414236137 cites W2133904925 @default.
- W2414236137 cites W2135804102 @default.
- W2414236137 cites W2162616258 @default.
- W2414236137 cites W2162652272 @default.
- W2414236137 cites W2164089346 @default.
- W2414236137 cites W2165200875 @default.
- W2414236137 cites W2166005458 @default.
- W2414236137 cites W2168876694 @default.
- W2414236137 cites W2168964544 @default.
- W2414236137 cites W2169894356 @default.
- W2414236137 cites W2170210469 @default.
- W2414236137 cites W2184143278 @default.
- W2414236137 cites W2202212112 @default.
- W2414236137 cites W2266821075 @default.
- W2414236137 cites W2283988548 @default.
- W2414236137 cites W2285646371 @default.
- W2414236137 cites W2287351208 @default.
- W2414236137 cites W2295231433 @default.
- W2414236137 cites W2304098217 @default.
- W2414236137 cites W2315899065 @default.
- W2414236137 cites W2317225665 @default.
- W2414236137 cites W2318839442 @default.
- W2414236137 cites W2326075804 @default.
- W2414236137 cites W2346868631 @default.
- W2414236137 cites W2398489629 @default.
- W2414236137 cites W2416064482 @default.
- W2414236137 doi "https://doi.org/10.1080/14712598.2016.1196182" @default.
- W2414236137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27248482" @default.
- W2414236137 hasPublicationYear "2016" @default.
- W2414236137 type Work @default.
- W2414236137 sameAs 2414236137 @default.
- W2414236137 citedByCount "24" @default.
- W2414236137 countsByYear W24142361372017 @default.
- W2414236137 countsByYear W24142361372018 @default.
- W2414236137 countsByYear W24142361372019 @default.
- W2414236137 countsByYear W24142361372020 @default.
- W2414236137 countsByYear W24142361372021 @default.
- W2414236137 countsByYear W24142361372022 @default.
- W2414236137 crossrefType "journal-article" @default.
- W2414236137 hasAuthorship W2414236137A5066079193 @default.
- W2414236137 hasAuthorship W2414236137A5070756199 @default.
- W2414236137 hasConcept C126322002 @default.
- W2414236137 hasConcept C134018914 @default.
- W2414236137 hasConcept C142462285 @default.
- W2414236137 hasConcept C171089720 @default.