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- W2414236410 abstract "Given this evidence, we hypothesized that the soporific effects of AEA could be associated with increased AD levels. In the present study, extracellular AD levels were assessed in the basal forebrain via the microdialysis method. The basal forebrain was sampled because this region is particularly sensitive to AD. 22 The cholinergic neurons located in the basal forebrain are implicated in maintaining waking behavior, and it is hypothesized that sleep results from the accumulating AD, which then inhibits the activity of the wake-active cholinergic neurons.21 Our results show that systemic application of AEA leads to increased AD levels in the basal forebrain during the first 3 hours after injection, and total sleep time is increased in the third hour. These findings identify a possible mechanism by which the endocannabinoid system influences sleep." @default.
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- W2414236410 date "2003-01-01" @default.
- W2414236410 modified "2023-10-18" @default.
- W2414236410 title "Anandamide Enhances Extracellular Levels of Adenosine and Induces Sleep: An In Vivo Microdialysis Study BASIC RESEARCH" @default.
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