FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414247920> ?p ?o ?g. }

• W2414247920 endingPage "30" @default.
• W2414247920 startingPage "215" @default.
• W2414247920 abstract "Delivery of therapeutic agents to the eye requires efficient transport through cellular and extracellular barriers. We evaluated the rate of diffusive transport in excised porcine corneal stroma using fluorescently labeled dextran molecules with hydrodynamic radii ranging from 1.3 to 34 nm. Fluorescence correlation spectroscopy (FCS) was used to measure diffusion coefficients of dextran molecules in the excised porcine corneal stroma. The preferential sensitivity of FCS to diffusion along two dimensions was used to differentially probe diffusion along the directions parallel to and perpendicular to the collagen lamellae of the corneal stroma. In order to develop an understanding of how size affects diffusion in cornea, diffusion coefficients in cornea were compared to diffusion coefficients measured in a simple buffer solution. Dextran molecules diffuse more slowly in cornea as compared to buffer solution. The reduction in diffusion coefficient is modest however (67% smaller), and is uniform over the range of sizes that we measured. This indicates that, for dextrans in the 1.3 to 34 nm range, the diffusion landscape of corneal stroma can be represented as a simple liquid with a viscosity approximately 1.5 times that of water. Diffusion coefficients measured parallel vs. perpendicular to the collagen lamellae were indistinguishable. This indicates that diffusion in the corneal stroma is not highly anisotropic. Our results support the notion that the corneal stroma is highly permeable and isotropic to transport of hydrophilic molecules and particles with hydrodynamic radii up to at least 34 nm." @default.
• W2414247920 created "2016-06-24" @default.
• W2414247920 creator A5004653124 @default.
• W2414247920 creator A5042680065 @default.
• W2414247920 creator A5049743676 @default.
• W2414247920 date "2015-09-01" @default.
• W2414247920 modified "2023-09-23" @default.
• W2414247920 title "Size-Dependent Diffusion of Dextrans in Excised Porcine Corneal Stroma." @default.
• W2414247920 cites W1542853183 @default.
• W2414247920 cites W1545213967 @default.
• W2414247920 cites W196823532 @default.
• W2414247920 cites W1968432716 @default.
• W2414247920 cites W1975162262 @default.
• W2414247920 cites W1976144051 @default.
• W2414247920 cites W1989850256 @default.
• W2414247920 cites W1996853317 @default.
• W2414247920 cites W2006008435 @default.
• W2414247920 cites W2009473148 @default.
• W2414247920 cites W2009822272 @default.
• W2414247920 cites W2018516156 @default.
• W2414247920 cites W2019450834 @default.
• W2414247920 cites W2023903257 @default.
• W2414247920 cites W2025624506 @default.
• W2414247920 cites W2027429271 @default.
• W2414247920 cites W2029230396 @default.
• W2414247920 cites W2042740379 @default.
• W2414247920 cites W2053926496 @default.
• W2414247920 cites W2060569670 @default.
• W2414247920 cites W2064423665 @default.
• W2414247920 cites W2065359937 @default.
• W2414247920 cites W2069557849 @default.
• W2414247920 cites W2074073922 @default.
• W2414247920 cites W2090023297 @default.
• W2414247920 cites W2094502556 @default.
• W2414247920 cites W2101825522 @default.
• W2414247920 cites W2115106713 @default.
• W2414247920 cites W2136180087 @default.
• W2414247920 cites W2156375169 @default.
• W2414247920 cites W2160269316 @default.
• W2414247920 cites W2163126094 @default.
• W2414247920 cites W2165278803 @default.
• W2414247920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27281957" @default.
• W2414247920 hasPublicationYear "2015" @default.
• W2414247920 type Work @default.
• W2414247920 sameAs 2414247920 @default.
• W2414247920 citedByCount "4" @default.
• W2414247920 countsByYear W24142479202015 @default.
• W2414247920 countsByYear W24142479202021 @default.
• W2414247920 countsByYear W24142479202023 @default.
• W2414247920 crossrefType "journal-article" @default.
• W2414247920 hasAuthorship W2414247920A5004653124 @default.
• W2414247920 hasAuthorship W2414247920A5042680065 @default.
• W2414247920 hasAuthorship W2414247920A5049743676 @default.
• W2414247920 hasConcept C120665830 @default.
• W2414247920 hasConcept C121332964 @default.
• W2414247920 hasConcept C12554922 @default.
• W2414247920 hasConcept C142724271 @default.
• W2414247920 hasConcept C144618238 @default.
• W2414247920 hasConcept C162324750 @default.
• W2414247920 hasConcept C176217482 @default.
• W2414247920 hasConcept C178790620 @default.
• W2414247920 hasConcept C184050105 @default.
• W2414247920 hasConcept C185592680 @default.
• W2414247920 hasConcept C192562407 @default.
• W2414247920 hasConcept C199631012 @default.
• W2414247920 hasConcept C204232928 @default.
• W2414247920 hasConcept C21547014 @default.
• W2414247920 hasConcept C2524010 @default.
• W2414247920 hasConcept C2776882836 @default.
• W2414247920 hasConcept C2777339698 @default.
• W2414247920 hasConcept C32909587 @default.
• W2414247920 hasConcept C33923547 @default.
• W2414247920 hasConcept C43617362 @default.
• W2414247920 hasConcept C52124034 @default.
• W2414247920 hasConcept C57736034 @default.
• W2414247920 hasConcept C69357855 @default.
• W2414247920 hasConcept C71924100 @default.
• W2414247920 hasConcept C86803240 @default.
• W2414247920 hasConcept C97355855 @default.
• W2414247920 hasConceptScore W2414247920C120665830 @default.
• W2414247920 hasConceptScore W2414247920C121332964 @default.
• W2414247920 hasConceptScore W2414247920C12554922 @default.
• W2414247920 hasConceptScore W2414247920C142724271 @default.
• W2414247920 hasConceptScore W2414247920C144618238 @default.
• W2414247920 hasConceptScore W2414247920C162324750 @default.
• W2414247920 hasConceptScore W2414247920C176217482 @default.
• W2414247920 hasConceptScore W2414247920C178790620 @default.
• W2414247920 hasConceptScore W2414247920C184050105 @default.
• W2414247920 hasConceptScore W2414247920C185592680 @default.
• W2414247920 hasConceptScore W2414247920C192562407 @default.
• W2414247920 hasConceptScore W2414247920C199631012 @default.
• W2414247920 hasConceptScore W2414247920C204232928 @default.
• W2414247920 hasConceptScore W2414247920C21547014 @default.
• W2414247920 hasConceptScore W2414247920C2524010 @default.
• W2414247920 hasConceptScore W2414247920C2776882836 @default.
• W2414247920 hasConceptScore W2414247920C2777339698 @default.
• W2414247920 hasConceptScore W2414247920C32909587 @default.
• W2414247920 hasConceptScore W2414247920C33923547 @default.

• next