Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414256204> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2414256204 endingPage "74" @default.
- W2414256204 startingPage "351" @default.
- W2414256204 abstract "Cyclosporin A (CsA), a clinically potent immunosuppressive agent, shows preferential biologic activity against certain lymphocyte subsets. To investigate this activity, we used flow cytometry to separate two distinct lymphocyte populations from unfractionated human peripheral blood lymphocytes, based on their different binding affinity for a biologically active fluorescent, dansylated cyclosporin (dans-CsA) derivative. The separate lymphocyte populations demonstrated different resting plasma membrane potentials. The two lymphocyte populations also had different levels of interleukin-2 (IL-2) receptors and shifted plasma membrane potential differently upon treatment with cyclosporin and lymphokine IL-2. The cell population that bound more dans-CsA contained the cells which possessed IL-2 receptors and responded to CsA and IL-2 with changes in membrane potential. The cell population that did not effectively bind dans-CsA lacked IL-2 receptors and did not respond to CsA or IL-2 with immediate membrane potential changes. Furthermore, stimulation studies of these separated two lymphocyte populations with phytohemagglutinin in the presence and absence of CsA revealed that only the population which binds a low level of dans-CsA shows a marked difference in membrane potential between the cells stimulated in the presence and absence of CsA. We concluded that ion flux changes caused by CsA affect the activation process of naive lymphocytes but not that of already stimulated ones. It can also be postulated that the ion flux changing property of CsA could constitute its primary or main mode of action." @default.
- W2414256204 created "2016-06-24" @default.
- W2414256204 creator A5023497883 @default.
- W2414256204 creator A5036652138 @default.
- W2414256204 creator A5088162141 @default.
- W2414256204 creator A5089312314 @default.
- W2414256204 date "1987-01-01" @default.
- W2414256204 modified "2023-10-14" @default.
- W2414256204 title "Lymphocyte populations with different sensitivity to cyclosporin have different plasma membrane potentials." @default.
- W2414256204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3509802" @default.
- W2414256204 hasPublicationYear "1987" @default.
- W2414256204 type Work @default.
- W2414256204 sameAs 2414256204 @default.
- W2414256204 citedByCount "0" @default.
- W2414256204 crossrefType "journal-article" @default.
- W2414256204 hasAuthorship W2414256204A5023497883 @default.
- W2414256204 hasAuthorship W2414256204A5036652138 @default.
- W2414256204 hasAuthorship W2414256204A5088162141 @default.
- W2414256204 hasAuthorship W2414256204A5089312314 @default.
- W2414256204 hasConcept C12554922 @default.
- W2414256204 hasConcept C126322002 @default.
- W2414256204 hasConcept C134018914 @default.
- W2414256204 hasConcept C170493617 @default.
- W2414256204 hasConcept C203014093 @default.
- W2414256204 hasConcept C24998067 @default.
- W2414256204 hasConcept C2777371288 @default.
- W2414256204 hasConcept C2777761686 @default.
- W2414256204 hasConcept C2908647359 @default.
- W2414256204 hasConcept C2992881475 @default.
- W2414256204 hasConcept C49382859 @default.
- W2414256204 hasConcept C553184892 @default.
- W2414256204 hasConcept C71924100 @default.
- W2414256204 hasConcept C86803240 @default.
- W2414256204 hasConcept C8891405 @default.
- W2414256204 hasConcept C95444343 @default.
- W2414256204 hasConcept C98274493 @default.
- W2414256204 hasConcept C99454951 @default.
- W2414256204 hasConceptScore W2414256204C12554922 @default.
- W2414256204 hasConceptScore W2414256204C126322002 @default.
- W2414256204 hasConceptScore W2414256204C134018914 @default.
- W2414256204 hasConceptScore W2414256204C170493617 @default.
- W2414256204 hasConceptScore W2414256204C203014093 @default.
- W2414256204 hasConceptScore W2414256204C24998067 @default.
- W2414256204 hasConceptScore W2414256204C2777371288 @default.
- W2414256204 hasConceptScore W2414256204C2777761686 @default.
- W2414256204 hasConceptScore W2414256204C2908647359 @default.
- W2414256204 hasConceptScore W2414256204C2992881475 @default.
- W2414256204 hasConceptScore W2414256204C49382859 @default.
- W2414256204 hasConceptScore W2414256204C553184892 @default.
- W2414256204 hasConceptScore W2414256204C71924100 @default.
- W2414256204 hasConceptScore W2414256204C86803240 @default.
- W2414256204 hasConceptScore W2414256204C8891405 @default.
- W2414256204 hasConceptScore W2414256204C95444343 @default.
- W2414256204 hasConceptScore W2414256204C98274493 @default.
- W2414256204 hasConceptScore W2414256204C99454951 @default.
- W2414256204 hasIssue "5-6" @default.
- W2414256204 hasLocation W24142562041 @default.
- W2414256204 hasOpenAccess W2414256204 @default.
- W2414256204 hasPrimaryLocation W24142562041 @default.
- W2414256204 hasRelatedWork W1831503676 @default.
- W2414256204 hasRelatedWork W1986991905 @default.
- W2414256204 hasRelatedWork W2067418472 @default.
- W2414256204 hasRelatedWork W2403568796 @default.
- W2414256204 hasRelatedWork W2410833002 @default.
- W2414256204 hasRelatedWork W2411603695 @default.
- W2414256204 hasRelatedWork W2412287469 @default.
- W2414256204 hasRelatedWork W2413309754 @default.
- W2414256204 hasRelatedWork W2414256204 @default.
- W2414256204 hasRelatedWork W199157789 @default.
- W2414256204 hasVolume "18" @default.
- W2414256204 isParatext "false" @default.
- W2414256204 isRetracted "false" @default.
- W2414256204 magId "2414256204" @default.
- W2414256204 workType "article" @default.