Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414274468> ?p ?o ?g. }
- W2414274468 endingPage "774" @default.
- W2414274468 startingPage "761" @default.
- W2414274468 abstract "Breast cancer is the most common female cancer, affecting approximately one in eight women during their life-time. Besides environmental triggers and hormones, inherited mutations in the breast cancer 1 (BRCA1) or BRCA2 genes markedly increase the risk for the development of breast cancer. Here, using two different mouse models, we show that genetic inactivation of the key osteoclast differentiation factor RANK in the mammary epithelium markedly delayed onset, reduced incidence, and attenuated progression of Brca1;p53 mutation-driven mammary cancer. Long-term pharmacological inhibition of the RANK ligand RANKL in mice abolished the occurrence of Brca1 mutation-driven pre-neoplastic lesions. Mechanistically, genetic inactivation of Rank or RANKL/RANK blockade impaired proliferation and expansion of both murine Brca1;p53 mutant mammary stem cells and mammary progenitors from human BRCA1 mutation carriers. In addition, genome variations within the RANK locus were significantly associated with risk of developing breast cancer in women with BRCA1 mutations. Thus, RANKL/RANK control progenitor cell expansion and tumorigenesis in inherited breast cancer. These results present a viable strategy for the possible prevention of breast cancer in BRCA1 mutant patients." @default.
- W2414274468 created "2016-06-24" @default.
- W2414274468 creator A5008342240 @default.
- W2414274468 creator A5012918723 @default.
- W2414274468 creator A5015052494 @default.
- W2414274468 creator A5015167759 @default.
- W2414274468 creator A5017092675 @default.
- W2414274468 creator A5020214196 @default.
- W2414274468 creator A5021827151 @default.
- W2414274468 creator A5023139971 @default.
- W2414274468 creator A5026022573 @default.
- W2414274468 creator A5030889614 @default.
- W2414274468 creator A5032969823 @default.
- W2414274468 creator A5039870429 @default.
- W2414274468 creator A5040334417 @default.
- W2414274468 creator A5040964442 @default.
- W2414274468 creator A5043055023 @default.
- W2414274468 creator A5043753389 @default.
- W2414274468 creator A5044186566 @default.
- W2414274468 creator A5046865036 @default.
- W2414274468 creator A5048087410 @default.
- W2414274468 creator A5053226783 @default.
- W2414274468 creator A5059310975 @default.
- W2414274468 creator A5061183186 @default.
- W2414274468 creator A5062853052 @default.
- W2414274468 creator A5065806351 @default.
- W2414274468 creator A5069693450 @default.
- W2414274468 creator A5070254609 @default.
- W2414274468 creator A5073107684 @default.
- W2414274468 creator A5078650117 @default.
- W2414274468 creator A5084303748 @default.
- W2414274468 creator A5084396272 @default.
- W2414274468 creator A5084710818 @default.
- W2414274468 creator A5085948558 @default.
- W2414274468 creator A5086377392 @default.
- W2414274468 creator A5088377418 @default.
- W2414274468 creator A5089706760 @default.
- W2414274468 date "2016-05-31" @default.
- W2414274468 modified "2023-10-16" @default.
- W2414274468 title "RANKL/RANK control Brca1 mutation-driven mammary tumors" @default.
- W2414274468 cites W1506203929 @default.
- W2414274468 cites W1534645474 @default.
- W2414274468 cites W1971949613 @default.
- W2414274468 cites W1984433201 @default.
- W2414274468 cites W1988548899 @default.
- W2414274468 cites W1989372485 @default.
- W2414274468 cites W1989938935 @default.
- W2414274468 cites W1992053982 @default.
- W2414274468 cites W2000067978 @default.
- W2414274468 cites W2023398724 @default.
- W2414274468 cites W2026889273 @default.
- W2414274468 cites W2036368043 @default.
- W2414274468 cites W2037046278 @default.
- W2414274468 cites W2039479054 @default.
- W2414274468 cites W2041594739 @default.
- W2414274468 cites W2044702943 @default.
- W2414274468 cites W2051320963 @default.
- W2414274468 cites W2063169494 @default.
- W2414274468 cites W2065766094 @default.
- W2414274468 cites W2067146626 @default.
- W2414274468 cites W2068673312 @default.
- W2414274468 cites W2094720383 @default.
- W2414274468 cites W2095250665 @default.
- W2414274468 cites W2096283457 @default.
- W2414274468 cites W2101791074 @default.
- W2414274468 cites W2107823127 @default.
- W2414274468 cites W2109465247 @default.
- W2414274468 cites W2109627278 @default.
- W2414274468 cites W2117963341 @default.
- W2414274468 cites W2124105940 @default.
- W2414274468 cites W2133022085 @default.
- W2414274468 cites W2134539328 @default.
- W2414274468 cites W2135548733 @default.
- W2414274468 cites W2139731637 @default.
- W2414274468 cites W2153361769 @default.
- W2414274468 cites W2153455967 @default.
- W2414274468 cites W2153864725 @default.
- W2414274468 cites W2158693623 @default.
- W2414274468 cites W2158740417 @default.
- W2414274468 cites W2159227882 @default.
- W2414274468 cites W2160005424 @default.
- W2414274468 cites W2166247816 @default.
- W2414274468 cites W2169353806 @default.
- W2414274468 cites W2197697401 @default.
- W2414274468 cites W2219359830 @default.
- W2414274468 cites W2253776931 @default.
- W2414274468 cites W2482202957 @default.
- W2414274468 cites W2560367415 @default.
- W2414274468 cites W4296300797 @default.
- W2414274468 doi "https://doi.org/10.1038/cr.2016.69" @default.
- W2414274468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5129883" @default.
- W2414274468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27241552" @default.
- W2414274468 hasPublicationYear "2016" @default.
- W2414274468 type Work @default.
- W2414274468 sameAs 2414274468 @default.
- W2414274468 citedByCount "121" @default.
- W2414274468 countsByYear W24142744682016 @default.
- W2414274468 countsByYear W24142744682017 @default.