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- W2414284098 abstract "_ The clinical and laboratory findings of 25 children with tuberculous meningitis treated at the Kings County Hospital Center during the years 1965 through 1970 were reviewed. Two of 19 strains of Mycobacterium tuberculosis isolated were primarily resistant to isoniazid, and one strain was also resistant to streptomycin. One child treated with first-line drugs died. The other child treated with a combination of first and second-line drugs recovered. A third patient from whom no orga nisms were recovered was presumably infected with a drug-resistant strain because the source case strain was drug-resistant. There was a close correlation between the drug-susceptibility patterns of matched patient and source case strains. It is recommended that initial therapy be based on the drug-susceptibility pattern of the source case strain because institution of therapy cannot wait for the isolation and drug-susceptibility pattern of the infecting strain. If not available, a combination of 2 first-line drugs and 2 second-line drugs should be used until this information is available. Other significant findings were the low initial tuberculin reactor rate (52 per cent) to 5 TU of purified protein derivative, and the finding that more than 50 per cent of the patients were ad mitted during the late stages of disease." @default.
- W2414284098 created "2016-06-24" @default.
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- W2414284098 date "1973-01-01" @default.
- W2414284098 modified "2023-09-27" @default.
- W2414284098 title "A Review of 25 Cases Observed between the Years 1965and 1970at the Kings County Medical Center of Brooklyn with Special Reference to the Problem of Infection with Primary Drug-Resistant Strains of M. tuberculosis':" @default.
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