FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414310754> ?p ?o ?g. }

• W2414310754 abstract "Circadian clocks orchestrate essential physiology in response to various cues, yet their mechanistic and functional plasticity remains unclear. Here, we investigated Clock(Δ19/+) heterozygous (Clk/+) mice, known to display lengthened periodicity and dampened amplitude, as a model of partially perturbed clocks. Interestingly, Clk/+ mice exhibited improved glycemic control and resistance to circadian period lengthening under high-fat diet (HFD). Furthermore, BMAL1 protein levels in Clk/+ mouse liver were upregulated compared with wild-type (WT) mice under HFD. Pharmacological and molecular studies showed that BMAL1 turnover entailed proteasomal and autophagic activities, and CLOCKΔ19 attenuated both processes. Consistent with an important role of BMAL1 in glycemic control, enhanced activation of insulin signaling was observed in Clk/+ mice relative to WT in HFD. Finally, transcriptome analysis revealed reprogramming of clock-controlled metabolic genes in Clk/+ mice. Our results demonstrate a novel role of autophagy in circadian regulation and reveal an unforeseen plasticity of circadian and metabolic networks." @default.
• W2414310754 created "2016-06-24" @default.
• W2414310754 creator A5004473991 @default.
• W2414310754 creator A5004781130 @default.
• W2414310754 creator A5023626511 @default.
• W2414310754 creator A5029584017 @default.
• W2414310754 creator A5038166543 @default.
• W2414310754 creator A5039810903 @default.
• W2414310754 creator A5041790429 @default.
• W2414310754 creator A5052434097 @default.
• W2414310754 creator A5058469124 @default.
• W2414310754 creator A5077051287 @default.
• W2414310754 date "2015-07-31" @default.
• W2414310754 modified "2023-09-24" @default.
• W2414310754 title "Dual attenuation of proteasomal and autophagic BMAL1 degradation in ClockΔ19/+ mice contributes to improved glucose homeostasis" @default.
• W2414310754 cites W1788453541 @default.
• W2414310754 cites W1841116434 @default.
• W2414310754 cites W1964557069 @default.
• W2414310754 cites W1968444524 @default.
• W2414310754 cites W1970657971 @default.
• W2414310754 cites W1976540475 @default.
• W2414310754 cites W1977392840 @default.
• W2414310754 cites W1980822337 @default.
• W2414310754 cites W1988808786 @default.
• W2414310754 cites W1989011389 @default.
• W2414310754 cites W1989760523 @default.
• W2414310754 cites W1990692725 @default.
• W2414310754 cites W1991097075 @default.
• W2414310754 cites W1997151200 @default.
• W2414310754 cites W2007247773 @default.
• W2414310754 cites W2007282158 @default.
• W2414310754 cites W2011072921 @default.
• W2414310754 cites W2013226891 @default.
• W2414310754 cites W2018257401 @default.
• W2414310754 cites W2021229976 @default.
• W2414310754 cites W2025391287 @default.
• W2414310754 cites W2025665129 @default.
• W2414310754 cites W2039503240 @default.
• W2414310754 cites W2044458189 @default.
• W2414310754 cites W2044925862 @default.
• W2414310754 cites W2047667443 @default.
• W2414310754 cites W2051818544 @default.
• W2414310754 cites W2053802535 @default.
• W2414310754 cites W2056265088 @default.
• W2414310754 cites W2063946784 @default.
• W2414310754 cites W2067927128 @default.
• W2414310754 cites W2073782682 @default.
• W2414310754 cites W2075757856 @default.
• W2414310754 cites W2075957423 @default.
• W2414310754 cites W2084770232 @default.
• W2414310754 cites W2091531174 @default.
• W2414310754 cites W2091912666 @default.
• W2414310754 cites W2097883984 @default.
• W2414310754 cites W2106648146 @default.
• W2414310754 cites W2107114877 @default.
• W2414310754 cites W2108235045 @default.
• W2414310754 cites W2110488158 @default.
• W2414310754 cites W2111907750 @default.
• W2414310754 cites W2123319274 @default.
• W2414310754 cites W2124659072 @default.
• W2414310754 cites W2125833190 @default.
• W2414310754 cites W2128480865 @default.
• W2414310754 cites W2132222938 @default.
• W2414310754 cites W2140814221 @default.
• W2414310754 cites W2140968650 @default.
• W2414310754 cites W2141478497 @default.
• W2414310754 cites W2144479739 @default.
• W2414310754 cites W2145967879 @default.
• W2414310754 cites W2147335424 @default.
• W2414310754 cites W2147712103 @default.
• W2414310754 cites W2157481078 @default.
• W2414310754 cites W2162650381 @default.
• W2414310754 cites W2167389860 @default.
• W2414310754 cites W2356498392 @default.
• W2414310754 cites W2602035017 @default.
• W2414310754 cites W602014734 @default.
• W2414310754 doi "https://doi.org/10.1038/srep12801" @default.
• W2414310754 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4521189" @default.
• W2414310754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26228022" @default.
• W2414310754 hasPublicationYear "2015" @default.
• W2414310754 type Work @default.
• W2414310754 sameAs 2414310754 @default.
• W2414310754 citedByCount "26" @default.
• W2414310754 countsByYear W24143107542015 @default.
• W2414310754 countsByYear W24143107542016 @default.
• W2414310754 countsByYear W24143107542017 @default.
• W2414310754 countsByYear W24143107542018 @default.
• W2414310754 countsByYear W24143107542019 @default.
• W2414310754 countsByYear W24143107542020 @default.
• W2414310754 countsByYear W24143107542021 @default.
• W2414310754 countsByYear W24143107542022 @default.
• W2414310754 crossrefType "journal-article" @default.
• W2414310754 hasAuthorship W2414310754A5004473991 @default.
• W2414310754 hasAuthorship W2414310754A5004781130 @default.
• W2414310754 hasAuthorship W2414310754A5023626511 @default.
• W2414310754 hasAuthorship W2414310754A5029584017 @default.
• W2414310754 hasAuthorship W2414310754A5038166543 @default.
• W2414310754 hasAuthorship W2414310754A5039810903 @default.
• W2414310754 hasAuthorship W2414310754A5041790429 @default.
• W2414310754 hasAuthorship W2414310754A5052434097 @default.

• next